Mr spectroscopy of brain tumors and correlation of metabolic changes with histological characteristics

BAKHRITDINOV Bekzod Rustamovich, ALIEV Mansur Abdukholikovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Introduction: Brain tumors remain one of the most challenging problems in neuro-oncology. Conventional MRI often fails to determine tumor grade accurately. Magnetic resonance spectroscopy (MRS) offers a promising non-invasive method for evaluating the metabolic profile of brain neoplasms. Methods: Forty-eight patients with brain tumors were examined using proton MRS (¹H-MRS). Tumors included gliomas (n=33), meningiomas (n=10), and metastases (n=5). Metabolites analyzed included choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lactate (Lac), and lipids (Lip). Correlation and comparative analysis were used to assess the relationship between metabolite levels and tumor histology. Results: Increased Cho, Lac, and Lip and decreased NAA strongly correlated with higher anaplasia grades (p<0.001). Cho/Cr and Lip/Cr were the most significant markers. NAA/Cr distinguished glioblastomas from metastases (p=0.04). MRS demonstrated high diagnostic value in evaluating metabolic features and malignancy. Discussion: MRS allows non-invasive grading, differential diagnosis of recurrence vs. radiation necrosis, and monitoring of treatment response. It can reduce the need for biopsy in complex cases and support clinical decision-making in neuro-oncology.

Maqola ma’lumotlari
MualliflarBAKHRITDINOV Bekzod Rustamovich, ALIEV Mansur Abdukholikovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-06-12
Jild10
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

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Kalit so‘zlar

магнитно-резонансная спектроскопия, опухоли мозга, метаболиты, анаплазия, глиобластома, метастазы, magnetic resonance spectroscopy, brain tumors, metabolites, anaplasia, glioblastoma, metastasis, magnit-rezonans spektroskopiya, miya o‘smalari, metabolitlar, анаплазия, glioblastoma, metastazlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APABAKHRITDINOV Bekzod Rustamovich, & ALIEV Mansur Abdukholikovich (2025). MR SPECTROSCOPY OF BRAIN TUMORS AND CORRELATION OF METABOLIC CHANGES WITH HISTOLOGICAL CHARACTERISTICS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(2). https://tadqiqot.uz/index.php/biomedicine/article/view/11522
GOST (OAK)BAKHRITDINOV Bekzod Rustamovich, ALIEV Mansur Abdukholikovich MR SPECTROSCOPY OF BRAIN TUMORS AND CORRELATION OF METABOLIC CHANGES WITH HISTOLOGICAL CHARACTERISTICS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 2.
MLABAKHRITDINOV Bekzod Rustamovich, and ALIEV Mansur Abdukholikovich. “MR SPECTROSCOPY OF BRAIN TUMORS AND CORRELATION OF METABOLIC CHANGES WITH HISTOLOGICAL CHARACTERISTICS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(2), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/11522
ChicagoBAKHRITDINOV Bekzod Rustamovich, and ALIEV Mansur Abdukholikovich. “MR SPECTROSCOPY OF BRAIN TUMORS AND CORRELATION OF METABOLIC CHANGES WITH HISTOLOGICAL CHARACTERISTICS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(2) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/11522
HarvardBAKHRITDINOV Bekzod Rustamovich, and ALIEV Mansur Abdukholikovich (2025) ‘MR SPECTROSCOPY OF BRAIN TUMORS AND CORRELATION OF METABOLIC CHANGES WITH HISTOLOGICAL CHARACTERISTICS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(2). https://tadqiqot.uz/index.php/biomedicine/article/view/11522
BibTeX
@article{bakhritdinovbekzodrustamovich2025,
  title = {MR SPECTROSCOPY OF BRAIN TUMORS AND CORRELATION OF METABOLIC CHANGES WITH HISTOLOGICAL CHARACTERISTICS},
  author = {BAKHRITDINOV Bekzod Rustamovich and ALIEV Mansur Abdukholikovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/11522}
}

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