Polymorphism of the mthfr C677T gene and its clinical and prognostic significance in COVID-19– associated ischemic stroke

Ибодов Бекзод Абдусатторович, Туйчибаева Нодира Мираталиевна, Азизова Раьно Бахадировна, Эгамов Хусен Эркинович

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-yil

Annotatsiya

This study was aimed at investigating the genetic, clinical, and laboratory parameters associated with the development of ischemic stroke in the context of COVID-19 infection. The study included 240 patients treated in clinical hospitals in Tashkent between 2020 and 2023. In all cases, SARS-CoV-2 infection was confirmed by PCR or antigen testing. The patients were divided into two groups: the main group with ischemic stroke (n = 120) and the control group without neurological complications (n = 120). During the study, polymorphisms of the MTHFR C677T, TNF-α rs1800629, IL-6 rs1800795, IL-1β rs1143627, and VEGF rs2010963 genes, levels of cytokines (IL-6, TNF-α, IL-1β, VEGFA), and clinical indicators (disease severity, neurological deficit, infarct volume) were examined. The obtained results confirmed that inflammation and thrombogenic mechanisms, driven by genetic factors, play an essential role in the pathogenesis of ischemic stroke associated with COVID-19.

Maqola ma’lumotlari
MualliflarИбодов Бекзод Абдусатторович, Туйчибаева Нодира Мираталиевна, Азизова Раьно Бахадировна, Эгамов Хусен Эркинович
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2025-11-19
Jild6
Son6/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

COVID-19, ишемический инсульт, MTHFR C677T, TNF-α rs1800629, IL-6 rs1800795, VEGF rs2010963, IL-1β rs1143627, цитокины, генетический полиморфизм, воспаление, гомоцистеин, тромбоз, COVID-19, ischemic stroke, MTHFR C677T, TNF-α rs1800629, IL-6 rs1800795, VEGF rs2010963, IL-1β rs1143627, cytokines, genetic polymorphism, inflammation, homocysteine, thrombosis, COVID-19, ишемик инсульт, MTHFR C677T, TNF-α rs1800629, IL-6 rs1800795, VEGF rs2010963, IL-1β rs1143627, цитокинлар, генетик полиморфизм, яллиғланиш, гомоцистеин, тромбоз

Ilmiy soha

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Iqtibos keltirish

APAИбодов Бекзод Абдусатторович, Туйчибаева Нодира Мираталиевна, Азизова Раьно Бахадировна, & Эгамов Хусен Эркинович (2025). POLYMORPHISM OF THE MTHFR C677T GENE AND ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE IN COVID-19– ASSOCIATED ISCHEMIC STROKE. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1). https://tadqiqot.uz/index.php/neurology/article/view/12917
GOST (OAK)Ибодов Бекзод Абдусатторович va b. POLYMORPHISM OF THE MTHFR C677T GENE AND ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE IN COVID-19– ASSOCIATED ISCHEMIC STROKE // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 6/1.
MLAИбодов Бекзод Абдусатторович, Туйчибаева Нодира Мираталиевна, Азизова Раьно Бахадировна, and Эгамов Хусен Эркинович. “POLYMORPHISM OF THE MTHFR C677T GENE AND ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE IN COVID-19– ASSOCIATED ISCHEMIC STROKE.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1), 2025. https://tadqiqot.uz/index.php/neurology/article/view/12917
ChicagoИбодов Бекзод Абдусатторович, Туйчибаева Нодира Мираталиевна, Азизова Раьно Бахадировна, and Эгамов Хусен Эркинович. “POLYMORPHISM OF THE MTHFR C677T GENE AND ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE IN COVID-19– ASSOCIATED ISCHEMIC STROKE.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1) (2025). https://tadqiqot.uz/index.php/neurology/article/view/12917
HarvardИбодов Бекзод Абдусатторович, Туйчибаева Нодира Мираталиевна, Азизова Раьно Бахадировна, and Эгамов Хусен Эркинович (2025) ‘POLYMORPHISM OF THE MTHFR C677T GENE AND ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE IN COVID-19– ASSOCIATED ISCHEMIC STROKE’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1). https://tadqiqot.uz/index.php/neurology/article/view/12917
BibTeX
@article{article2025,
  title = {POLYMORPHISM OF THE MTHFR C677T GENE AND ITS CLINICAL AND PROGNOSTIC SIGNIFICANCE IN COVID-19– ASSOCIATED ISCHEMIC STROKE},
  author = {Ибодов Бекзод Абдусатторович and Туйчибаева Нодира Мираталиевна and Азизова Раьно Бахадировна and Эгамов Хусен Эркинович},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2025},
  volume = {6},
  number = {6/1},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/12917}
}

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