Methods of artificial feeding of rat pups: basic models

Boratova M.A.

Гуманитар ва табиий фанлар журнали · 2026-yil

Annotatsiya

The neonatal period is considered one of the most critical stages of organismal development, during which the type of nutrition significantly influences the morphological and functional maturation of the digestive system. In particular, the structural development of the small intestine, differentiation of enterocytes, enzymatic activity, and formation of local immune defense mechanisms are closely associated with feeding patterns. Breast milk contains biologically active substances, immunoglobulins, and growth factors that create physiologically optimal conditions for neonatal development. In contrast, artificial feeding may lead to various morphological and functional alterations in the intestine due to the absence or insufficiency of these natural components.This article presents an analysis of the main experimental models of artificial feeding in neonatal rats, their methodological characteristics, and their effects on intestinal development. The reviewed studies included the “pup-in-a-cup” artificial rearing system, gastric tube feeding methods, and the use of milk substitute formulas such as RMS-2A and RMS-2B. Artificial feeding conditions were associated with significant changes in villus length, crypt depth, enterocyte ultrastructure, and disaccharidase enzyme activity in neonatal rats.According to the literature, high intestinal lactase activity in suckling rats is maintained during the first two weeks after birth. In artificially reared animals, a decrease in jejunal and ileal lactase activity was observed, whereas sucrase activity increased prematurely. Furthermore, artificial feeding was characterized by prolonged persistence of immature enterocyte features, including supranuclear vacuoles, apical tubular systems, and pinocytotic vesicles. Morphometric analyses also demonstrated increased crypt depth and remodeling of the intestinal mucosa.In artificial rearing systems, the infusion rate and duration of milk formula administration were adjusted individually to approximate physiological feeding conditions. Studies demonstrated that neonatal rats fed with RMS-2A and RMS-2B formulas showed growth rates comparable to naturally suckled animals. In addition, maintenance of sterility, cooled feeding systems, and pathogen-free housing conditions were considered essential factors for preventing infectious complications and edema syndrome.Thus, experimental models of artificial feeding in neonatal rats represent effective platforms for investigating intestinal development, enzymatic maturation, and morphofunctional alterations. These models have important scientific value for fundamental and applied research in neonatology, gastroenterology, and experimental morphology.

Maqola ma’lumotlari
MualliflarBoratova M.A.
JurnalГуманитар ва табиий фанлар журнали
NashriyotEMU University
ISSN2026-2027, 2181-4007
Nashr sanasi2026-07-16
Son35
Betlar49-52
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

neonatal rats, artificial feeding, pup-in-a-cup, small intestine, morphology, lactase, enterocyte, experimental model.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APABoratova M.A. (2026). METHODS OF ARTIFICIAL FEEDING OF RAT PUPS: BASIC MODELS. Гуманитар ва табиий фанлар журнали, (35), 49-52. https://journals.tnmu.uz/index.php/gtfj/article/view/5875
GOST (OAK)Boratova M.A. METHODS OF ARTIFICIAL FEEDING OF RAT PUPS: BASIC MODELS // Гуманитар ва табиий фанлар журнали. – 2026. – № 35. – P. 49-52.
MLABoratova M.A. “METHODS OF ARTIFICIAL FEEDING OF RAT PUPS: BASIC MODELS.” Гуманитар ва табиий фанлар журнали, (35), 49-52, 2026. https://journals.tnmu.uz/index.php/gtfj/article/view/5875
ChicagoBoratova M.A. “METHODS OF ARTIFICIAL FEEDING OF RAT PUPS: BASIC MODELS.” Гуманитар ва табиий фанлар журнали, (35), 49-52 (2026). https://journals.tnmu.uz/index.php/gtfj/article/view/5875
HarvardBoratova M.A (2026) ‘METHODS OF ARTIFICIAL FEEDING OF RAT PUPS: BASIC MODELS’, Гуманитар ва табиий фанлар журнали, (35), 49-52. https://journals.tnmu.uz/index.php/gtfj/article/view/5875
BibTeX
@article{boratovama2026,
  title = {METHODS OF ARTIFICIAL FEEDING OF RAT PUPS: BASIC MODELS},
  author = {Boratova M.A.},
  journal = {Гуманитар ва табиий фанлар журнали},
  year = {2026},
  number = {35},
  pages = {49-52},
  url = {https://journals.tnmu.uz/index.php/gtfj/article/view/5875}
}

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