Optimization of complex therapy for androgenetic alopecia: integrating clinical, immunogenetic, and biochemical mechanisms

Umurov F.F., Abidov Kh.A.

Гуманитар ва табиий фанлар журнали · 2026-yil

Annotatsiya

Androgenetic alopecia (AGA, ICD-10: L64) is the most common form of non-scarring alopecia worldwide, significantly impacting quality of life. Despite advances in understanding its pathogenesis, standard treatments (topical/oral minoxidil and 5α-reductase inhibitors) show limited efficacy in 30–40% of patients and do not address the full spectrum of contributing factors. This review synthesizes current data on the multifactorial pathogenesis of AGA, emphasizing the interplay of androgen-dependent mechanisms with immunogenetic factors (e.g., MTHFR, VEGF, KGF polymorphisms), biochemical markers (homocysteine, folate, vitamin B12), chronic microinflammation (IL-1, VEGF), and microvascular disturbances. Particular attention is given to the shift toward personalized, precision-medicine approaches incorporating trichoscopy, Doppler imaging, and biomarker profiling. Gaps in regional data, especially in Central Asian populations, justify comprehensive studies aimed at optimizing diagnostic algorithms and complex therapeutic protocols. Such integration is expected to improve treatment outcomes, reduce progression, and minimize side effects.

Maqola ma’lumotlari
MualliflarUmurov F.F., Abidov Kh.A.
JurnalГуманитар ва табиий фанлар журнали
NashriyotEMU University
ISSN2026-2027, 2181-4007
Nashr sanasi2026-07-16
Son35
Betlar74-83
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

androgenetic alopecia, immunogenetics, MTHFR, homocysteine, folate, vitamin B12, trichoscopy, personalized therapy, precision medicine

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUmurov F.F., Abidov Kh.A. (2026). OPTIMIZATION OF COMPLEX THERAPY FOR ANDROGENETIC ALOPECIA: INTEGRATING CLINICAL, IMMUNOGENETIC, AND BIOCHEMICAL MECHANISMS. Гуманитар ва табиий фанлар журнали, (35), 74-83. https://journals.tnmu.uz/index.php/gtfj/article/view/5880
GOST (OAK)Umurov F.F., Abidov Kh.A. OPTIMIZATION OF COMPLEX THERAPY FOR ANDROGENETIC ALOPECIA: INTEGRATING CLINICAL, IMMUNOGENETIC, AND BIOCHEMICAL MECHANISMS // Гуманитар ва табиий фанлар журнали. – 2026. – № 35. – P. 74-83.
MLAUmurov F.F., Abidov Kh.A. “OPTIMIZATION OF COMPLEX THERAPY FOR ANDROGENETIC ALOPECIA: INTEGRATING CLINICAL, IMMUNOGENETIC, AND BIOCHEMICAL MECHANISMS.” Гуманитар ва табиий фанлар журнали, (35), 74-83, 2026. https://journals.tnmu.uz/index.php/gtfj/article/view/5880
ChicagoUmurov F.F., Abidov Kh.A. “OPTIMIZATION OF COMPLEX THERAPY FOR ANDROGENETIC ALOPECIA: INTEGRATING CLINICAL, IMMUNOGENETIC, AND BIOCHEMICAL MECHANISMS.” Гуманитар ва табиий фанлар журнали, (35), 74-83 (2026). https://journals.tnmu.uz/index.php/gtfj/article/view/5880
HarvardUmurov F.F., Abidov Kh.A (2026) ‘OPTIMIZATION OF COMPLEX THERAPY FOR ANDROGENETIC ALOPECIA: INTEGRATING CLINICAL, IMMUNOGENETIC, AND BIOCHEMICAL MECHANISMS’, Гуманитар ва табиий фанлар журнали, (35), 74-83. https://journals.tnmu.uz/index.php/gtfj/article/view/5880
BibTeX
@article{umurovffabidovkha2026,
  title = {OPTIMIZATION OF COMPLEX THERAPY FOR ANDROGENETIC ALOPECIA: INTEGRATING CLINICAL, IMMUNOGENETIC, AND BIOCHEMICAL MECHANISMS},
  author = {Umurov F.F., Abidov Kh.A.},
  journal = {Гуманитар ва табиий фанлар журнали},
  year = {2026},
  number = {35},
  pages = {74-83},
  url = {https://journals.tnmu.uz/index.php/gtfj/article/view/5880}
}

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