The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy

Абдуллаев , Т, Цой , И, Мирзарахимова , С, Худойберганов , О, Курбанов , Н, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Khudoyberganov , Otabek, Kurbanov , Nurali, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Хudoyberganov , Otabek, Kurbanov , Nurali

O‘zbekiston кardiologiyasi · 2024-yil

Annotatsiya

Background. Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening condition associated with heart failure after childbirth. Genetic factors, including the angiotensin-converting enzyme (ACE) gene polymorphism, may influence the course of the disease. Materials and methods. The study included 102 patients with PPCM and 65 healthy women. Genotyping of the ACE I/D polymorphism was performed using PCR. Clinical, functional, and echocardiographic parameters were assessed. Results. Eleven (10.8%) patients were diagnosed with functional class II, 64 (62.7%) with class III, and 27 (26.5%) with class IV. Distribution of the I/D genotypes: DD – 24 (23.5%), ID – 45 (44.1%), II – 33 (32.3%). Patients with the DD genotype had lower left ventricular ejection fraction (LVEF) and higher values for diastolic and systolic heart sizes. Over two years of observation, mortality from disease progression was 5% in the DD and ID subgroups, and 0% in the II subgroup. Conclusion. The I/D polymorphism of the ACE gene may affect left ventricular systolic and diastolic function in patients with PPCM. Carriers of the D allele and the DD genotype have a more unfavorable prognosis.

Maqola ma’lumotlari
MualliflarАбдуллаев , Т, Цой , И, Мирзарахимова , С, Худойберганов , О, Курбанов , Н, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Khudoyberganov , Otabek, Kurbanov , Nurali, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Хudoyberganov , Otabek, Kurbanov , Nurali
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2024-09-30
Jild1
Son3
Betlar170-178
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2024-1-00020
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2024-1-00020 · Maqolaning asl sahifasi

Kalit so‘zlar

peripartum cardiomyopathy, insertion-deletion polymorphism, prognosis, перипартальная кардиомиопатия, инсерционно-делеционный полиморфизм, прогноз, peripartum kardiomiopatiya, inser­siya-deletsiya polimorfizmi, prognoz

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАбдуллаев , Т, Цой , И, Мирзарахимова , С, Худойберганов , О, Курбанов , Н, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Khudoyberganov , Otabek, Kurbanov , Nurali, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Хudoyberganov , Otabek, & Kurbanov , Nurali (2024). The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy. O‘zbekiston кardiologiyasi, 1(3), 170-178. https://doi.org/10.70626/cardiouz-2024-1-00020
GOST (OAK)Абдуллаев , Т va b. The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy // O‘zbekiston кardiologiyasi. – 2024. – T. 1, № 3. – P. 170-178. – DOI: 10.70626/cardiouz-2024-1-00020.
MLAАбдуллаев , Т, Цой , И, Мирзарахимова , С, Худойберганов , О, Курбанов , Н, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Khudoyberganov , Otabek, Kurbanov , Nurali, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Хudoyberganov , Otabek, and Kurbanov , Nurali. “The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy.” O‘zbekiston кardiologiyasi, 1(3), 170-178, 2024. https://doi.org/10.70626/cardiouz-2024-1-00020
ChicagoАбдуллаев , Т, Цой , И, Мирзарахимова , С, Худойберганов , О, Курбанов , Н, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Khudoyberganov , Otabek, Kurbanov , Nurali, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Хudoyberganov , Otabek, and Kurbanov , Nurali. “The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy.” O‘zbekiston кardiologiyasi, 1(3), 170-178 (2024). https://doi.org/10.70626/cardiouz-2024-1-00020
HarvardАбдуллаев , Т, Цой , И, Мирзарахимова , С, Худойберганов , О, Курбанов , Н, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Khudoyberganov , Otabek, Kurbanov , Nurali, Abdullaev , Timur, Tsoi , Igor, Mirzarakhimova , Saodat, Хudoyberganov , Otabek, and Kurbanov , Nurali (2024) ‘The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy’, O‘zbekiston кardiologiyasi, 1(3), 170-178. https://doi.org/10.70626/cardiouz-2024-1-00020
BibTeX
@article{article2024,
  title = {The impact of angiotensin converting enzyme gene polymorphism on the prognosis of peripartum cardiomyopathy},
  author = {Абдуллаев , Т and Цой , И and Мирзарахимова , С and Худойберганов , О and Курбанов , Н and Abdullaev , Timur and Tsoi , Igor and Mirzarakhimova , Saodat and Khudoyberganov , Otabek and Kurbanov , Nurali and Abdullaev , Timur and Tsoi , Igor and Mirzarakhimova , Saodat and Хudoyberganov , Otabek and Kurbanov , Nurali},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2024},
  volume = {1},
  number = {3},
  pages = {170-178},
  doi = {10.70626/cardiouz-2024-1-00020},
  url = {https://doi.org/10.70626/cardiouz-2024-1-00020}
}

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