Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease

Мухамедова , Ш, Муллабаева , Г, Mukhamedova , Shokhista, Mullabaeva , Guzal, Muxamedova , Shoxista, Mullabaeva , Guzal

O‘zbekiston кardiologiyasi · 2024-yil

Annotatsiya

Background. Heart failure with preserved ejection fraction (HFpEF) is a complex clinical condition, often associated with chronic kidney disease (CKD). The interplay between these two conditions remains underexplored. This study aims to examine the phenotypic characteristics of patients with HFpEF in conjunction with CKD, with a focus on biomarker alterations and clinical outcomes. Materials and methods. The study enrolled 200 patients diagnosed with both HFpEF (ejection fraction ≥50%) and CKD stages 1-3b. Clinical data were collected, and various biomarkers, including NT-proBNP, cystatin C, and microalbuminuria (MAU), were measured using chemiluminescent immunoassay (COBAS e411, Roche HITACHI), fluorescent immunoassay (Finecare III PLUS analyzer), and turbidimetric testing (Mindray BS-380 analyzer), respectively. GFR was calculated using the CKD-EPI formula. Results. The results indicated a higher prevalence of Type 2 diabetes (T2D) and atrial fibrillation (AF) among patients with CKD stage 3b. Conversely, those with CKD stage 3a exhibited worse control over blood lipid levels. Notably, a decrease in GFR was significantly correlated with elevated levels of creatinine, cystatin C, and MAU. In patients with CKD stages 1-2, even though creatinine levels were normal, cystatin C and MAU levels were higher than the normative range. Conclusion. Among HFpEF patients, CKD stage 2 in combination with obesity was more common, with changes observed in renal biomarkers such as cystatin C and MAU, despite relatively normal GFR values. This highlights the importance of early detection and management of renal impairment in HFpEF patients, emphasizing a need for comprehensive cardiac and renal care.

Maqola ma’lumotlari
MualliflarМухамедова , Ш, Муллабаева , Г, Mukhamedova , Shokhista, Mullabaeva , Guzal, Muxamedova , Shoxista, Mullabaeva , Guzal
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2024-09-30
Jild1
Son3
Betlar179-187
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2024-1-00021
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2024-1-00021 · Maqolaning asl sahifasi

Kalit so‘zlar

heart failure, preserved ejection fraction, chronic kidney disease, cystatin C, NT-proBNP, microalbuminuria, Type 2 diabetes, atrial fibrillation, glomerular filtration rate, renal biomarkers, obesity, cердечная недостаточность, сохраненная фракция выброса, хроническая болезнь почек, цистатин С, NT-proBNP, микроальбуминурия, диабет 2 типа, фибрилляция предсердий, скорость клубочковой фильтрации, почечные маркеры, ожирение, yurak yetishmovchiligi, chiqarib tashlash fraksiyasi saqlangan, surunkali buyrak kasalligi, sistatin C, NT-proBNP, mikroalbuminuriya, 2-toifa qandli diabet, bo‘lmachalar fibrillyatsiyasi, glomerulyar filtratsiya tezligi, buyrak biomarkerlari, semizlik

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAМухамедова , Ш, Муллабаева , Г, Mukhamedova , Shokhista, Mullabaeva , Guzal, Muxamedova , Shoxista, & Mullabaeva , Guzal (2024). Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease. O‘zbekiston кardiologiyasi, 1(3), 179-187. https://doi.org/10.70626/cardiouz-2024-1-00021
GOST (OAK)Мухамедова , Ш va b. Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease // O‘zbekiston кardiologiyasi. – 2024. – T. 1, № 3. – P. 179-187. – DOI: 10.70626/cardiouz-2024-1-00021.
MLAМухамедова , Ш, Муллабаева , Г, Mukhamedova , Shokhista, Mullabaeva , Guzal, Muxamedova , Shoxista, and Mullabaeva , Guzal. “Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease.” O‘zbekiston кardiologiyasi, 1(3), 179-187, 2024. https://doi.org/10.70626/cardiouz-2024-1-00021
ChicagoМухамедова , Ш, Муллабаева , Г, Mukhamedova , Shokhista, Mullabaeva , Guzal, Muxamedova , Shoxista, and Mullabaeva , Guzal. “Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease.” O‘zbekiston кardiologiyasi, 1(3), 179-187 (2024). https://doi.org/10.70626/cardiouz-2024-1-00021
HarvardМухамедова , Ш, Муллабаева , Г, Mukhamedova , Shokhista, Mullabaeva , Guzal, Muxamedova , Shoxista, and Mullabaeva , Guzal (2024) ‘Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease’, O‘zbekiston кardiologiyasi, 1(3), 179-187. https://doi.org/10.70626/cardiouz-2024-1-00021
BibTeX
@article{article2024,
  title = {Phenotypic characteristics of patients with chronic heart failure and preserved ejection fraction in conjunction with chronic kidney disease},
  author = {Мухамедова , Ш and Муллабаева , Г and Mukhamedova , Shokhista and Mullabaeva , Guzal and Muxamedova , Shoxista and Mullabaeva , Guzal},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2024},
  volume = {1},
  number = {3},
  pages = {179-187},
  doi = {10.70626/cardiouz-2024-1-00021},
  url = {https://doi.org/10.70626/cardiouz-2024-1-00021}
}

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