Molecular genetic features of arterial hypertension in the aral sea region population

Ataniyazov , Xurshid, Fozilov Фозилов, Xurshid, Xamidullayeva , Gulnoz, Abdullaeva , G, Ataniyazov , Khurshid, Fozilov , Khurshid, Khamidullayeva , Gulnoz, Abdullaeva , Guzal, Атаниязов, Х, Фозилов, Х, Хамидуллаева, Г, Абдуллаева, Г

O‘zbekiston кardiologiyasi · 2024-yil

Annotatsiya

Background. Arterial hypertension (AH) is a complex, multifactorial disease that significantly contributes to cardiovascular diseases. It is particularly prevalent in the Aral Sea region, where both genetic and environmental factors play a crucial role. This study focuses on the molecular-genetic characteristics of AH in the population of this region. Materials and methods. The study was conducted on 1020 patients aged 40-70 years, diagnosed with AH at the Ellikkala District Medical Association in the Republic of Karakalpakstan. Genetic analysis was performed on 407 AH patients to identify polymorphisms in key genes associated with hypertension. Results. Three significant genetic polymorphisms were identified in the AH patients: the G1675A polymorphism in the AGTR2 gene, the G460T polymorphism in the ADD1 gene, and the C704T polymorphism in the AGT gene. These polymorphisms were found to be associated with AH development in the Aral Sea region population. Conclusion. This is the first large-scale molecular-genetic study of AH in the Aral Sea region, revealing genetic markers that contribute to the high prevalence of AH in this area. These findings will help in the development of a genetic risk calculator for cardiovascular diseases specific to the region.

Maqola ma’lumotlari
MualliflarAtaniyazov , Xurshid, Fozilov Фозилов, Xurshid, Xamidullayeva , Gulnoz, Abdullaeva , G, Ataniyazov , Khurshid, Fozilov , Khurshid, Khamidullayeva , Gulnoz, Abdullaeva , Guzal, Атаниязов, Х, Фозилов, Х, Хамидуллаева, Г, Абдуллаева, Г
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2024-09-27
Jild1
Son3
Betlar153-159
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2024-1-00018
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2024-1-00018 · Maqolaning asl sahifasi

Kalit so‘zlar

arterial hypertension, genetic polymorphisms, aral sea region, cardiovascular risk, molecular genetics, aртериальная гипертензия, генетические полиморфизмы, регион Аральского моря, сердечно-сосудистый риск, молекулярная генетика, arterial gipertenziya, genetik polimorfizmlar, orol dengizi mintaqasi, yurak-qon tomir xavfi, molekulyar genetik

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAtaniyazov , Xurshid, Fozilov Фозилов, Xurshid, Xamidullayeva , Gulnoz, Abdullaeva , G, Ataniyazov , Khurshid, Fozilov , Khurshid, Khamidullayeva , Gulnoz, Abdullaeva , Guzal, Атаниязов, Х, Фозилов, Х, Хамидуллаева, Г, & Абдуллаева, Г (2024). Molecular genetic features of arterial hypertension in the aral sea region population. O‘zbekiston кardiologiyasi, 1(3), 153-159. https://doi.org/10.70626/cardiouz-2024-1-00018
GOST (OAK)Ataniyazov , Xurshid va b. Molecular genetic features of arterial hypertension in the aral sea region population // O‘zbekiston кardiologiyasi. – 2024. – T. 1, № 3. – P. 153-159. – DOI: 10.70626/cardiouz-2024-1-00018.
MLAAtaniyazov , Xurshid, Fozilov Фозилов, Xurshid, Xamidullayeva , Gulnoz, Abdullaeva , G, Ataniyazov , Khurshid, Fozilov , Khurshid, Khamidullayeva , Gulnoz, Abdullaeva , Guzal, Атаниязов, Х, Фозилов, Х, Хамидуллаева, Г, and Абдуллаева, Г. “Molecular genetic features of arterial hypertension in the aral sea region population.” O‘zbekiston кardiologiyasi, 1(3), 153-159, 2024. https://doi.org/10.70626/cardiouz-2024-1-00018
ChicagoAtaniyazov , Xurshid, Fozilov Фозилов, Xurshid, Xamidullayeva , Gulnoz, Abdullaeva , G, Ataniyazov , Khurshid, Fozilov , Khurshid, Khamidullayeva , Gulnoz, Abdullaeva , Guzal, Атаниязов, Х, Фозилов, Х, Хамидуллаева, Г, and Абдуллаева, Г. “Molecular genetic features of arterial hypertension in the aral sea region population.” O‘zbekiston кardiologiyasi, 1(3), 153-159 (2024). https://doi.org/10.70626/cardiouz-2024-1-00018
HarvardAtaniyazov , Xurshid, Fozilov Фозилов, Xurshid, Xamidullayeva , Gulnoz, Abdullaeva , G, Ataniyazov , Khurshid, Fozilov , Khurshid, Khamidullayeva , Gulnoz, Abdullaeva , Guzal, Атаниязов, Х, Фозилов, Х, Хамидуллаева, Г, and Абдуллаева, Г (2024) ‘Molecular genetic features of arterial hypertension in the aral sea region population’, O‘zbekiston кardiologiyasi, 1(3), 153-159. https://doi.org/10.70626/cardiouz-2024-1-00018
BibTeX
@article{ataniyazovxurshid2024,
  title = {Molecular genetic features of arterial hypertension in the aral sea region population},
  author = {Ataniyazov , Xurshid and Fozilov Фозилов, Xurshid and Xamidullayeva , Gulnoz and Abdullaeva , G and Ataniyazov , Khurshid and Fozilov , Khurshid and Khamidullayeva , Gulnoz and Abdullaeva , Guzal and Атаниязов, Х and Фозилов, Х and Хамидуллаева, Г and Абдуллаева, Г},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2024},
  volume = {1},
  number = {3},
  pages = {153-159},
  doi = {10.70626/cardiouz-2024-1-00018},
  url = {https://doi.org/10.70626/cardiouz-2024-1-00018}
}

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