Background. The purpose of this study was to compare the tolerability, safety, and clinical efficacy of generic and original apixaban in patients with arterial hypertension (AH) and permanent non-valvular atrial fibrillation (AF). Materials and methods. This prospective study included 50 patients with hypertension stages 1-3 and permanent non-valvular atrial fibrillation. The patients were divided into two groups: Group 1 (n=25) received generic apixaban, and Group 2 (n=25) received the original apixaban. Both groups were administered 10 mg of apixaban daily, in combination with standard antihypertensive therapy. Clinical and laboratory evaluations were performed before and after one month of treatment, including measurements of blood pressure, echocardiography, biochemical blood tests, and coagulogram. Results. A significant reduction in systolic and diastolic blood pressure was observed in both groups. No significant changes were detected in echocardiographic parameters. Biochemical tests revealed a decrease in creatinine and uric acid levels, and an increase in the prothrombin ratio, indicating a positive anticoagulant effect. Conclusion. Both generic and original apixaban showed similar safety and clinical efficacy in patients with arterial hypertension and permanent atrial fibrillation, demonstrating significant reductions in blood pressure and positive anticoagulant effects.
| Mualliflar | Хамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh |
|---|---|
| Jurnal | O‘zbekiston кardiologiyasi |
| Nashr sanasi | 2024-06-30 |
| Jild | 1 |
| Son | 2 |
| Betlar | 112-121 |
| Til | Rus |
| DOI | 10.70626/cardiouz-2024-1-00014 |
DOI: 10.70626/cardiouz-2024-1-00014 · Maqolaning asl sahifasi
arterial hypertension, atrial fibrillation, generic apixaban, original apixaban, anticoagulant therapy, aртериальная гипертензия, фибрилляция предсердий, генерический апиксабан, оригинальный апиксабан, антикоагулянтная терапия, arterial gipertenziya, atrial fibrillyatsiya, generik apiksaban, original apiksaban, antikoagulyant terapiya
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