Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation

Хамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh

O‘zbekiston кardiologiyasi · 2024-yil

Annotatsiya

Background. The purpose of this study was to compare the tolerability, safety, and clinical efficacy of generic and original apixaban in patients with arterial hypertension (AH) and permanent non-valvular atrial fibrillation (AF). Materials and methods. This prospective study included 50 patients with hypertension stages 1-3 and permanent non-valvular atrial fibrillation. The patients were divided into two groups: Group 1 (n=25) received generic apixaban, and Group 2 (n=25) received the original apixaban. Both groups were administered 10 mg of apixaban daily, in combination with standard antihypertensive therapy. Clinical and laboratory evaluations were performed before and after one month of treatment, including measurements of blood pressure, echocardiography, biochemical blood tests, and coagulogram. Results. A significant reduction in systolic and diastolic blood pressure was observed in both groups. No significant changes were detected in echocardiographic parameters. Biochemical tests revealed a decrease in creatinine and uric acid levels, and an increase in the prothrombin ratio, indicating a positive anticoagulant effect. Conclusion. Both generic and original apixaban showed similar safety and clinical efficacy in patients with arterial hypertension and permanent atrial fibrillation, demonstrating significant reductions in blood pressure and positive anticoagulant effects.

Maqola ma’lumotlari
MualliflarХамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2024-06-30
Jild1
Son2
Betlar112-121
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2024-1-00014
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2024-1-00014 · Maqolaning asl sahifasi

Kalit so‘zlar

arterial hypertension, atrial fibrillation, generic apixaban, original apixaban, anticoagulant therapy, aртериальная гипертензия, фибрилляция предсердий, генерический апиксабан, оригинальный апиксабан, антикоагулянтная терапия, arterial gipertenziya, atrial fibrillyatsiya, generik apiksaban, original apiksaban, antikoagulyant terapiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAХамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, & Radzhabova, Guliruh (2024). Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation. O‘zbekiston кardiologiyasi, 1(2), 112-121. https://doi.org/10.70626/cardiouz-2024-1-00014
GOST (OAK)Хамидуллаева , Г va b. Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation // O‘zbekiston кardiologiyasi. – 2024. – T. 1, № 2. – P. 112-121. – DOI: 10.70626/cardiouz-2024-1-00014.
MLAХамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, and Radzhabova, Guliruh. “Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation.” O‘zbekiston кardiologiyasi, 1(2), 112-121, 2024. https://doi.org/10.70626/cardiouz-2024-1-00014
ChicagoХамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, and Radzhabova, Guliruh. “Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation.” O‘zbekiston кardiologiyasi, 1(2), 112-121 (2024). https://doi.org/10.70626/cardiouz-2024-1-00014
HarvardХамидуллаева , Г, Абдуллаева , Г, Тургунбоев , С, Сафаров , Ж, Ибрагимова , И, Раджабова, Guliruh, Khamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, Radzhabova, Guliruh, Хamidullaeva , Gulnoz, Abdullaeva, Guzal, Turgunboev , Saidburkhan, Safarov , Jamshiddin, Ibragimova , Iroda, and Radzhabova, Guliruh (2024) ‘Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation’, O‘zbekiston кardiologiyasi, 1(2), 112-121. https://doi.org/10.70626/cardiouz-2024-1-00014
BibTeX
@article{article2024,
  title = {Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation},
  author = {Хамидуллаева , Г and Абдуллаева , Г and Тургунбоев , С and Сафаров , Ж and Ибрагимова , И and Раджабова, Guliruh and Khamidullaeva , Gulnoz and Abdullaeva, Guzal and Turgunboev , Saidburkhan and Safarov , Jamshiddin and Ibragimova , Iroda and Radzhabova, Guliruh and Хamidullaeva , Gulnoz and Abdullaeva, Guzal and Turgunboev , Saidburkhan and Safarov , Jamshiddin and Ibragimova , Iroda and Radzhabova, Guliruh},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2024},
  volume = {1},
  number = {2},
  pages = {112-121},
  doi = {10.70626/cardiouz-2024-1-00014},
  url = {https://doi.org/10.70626/cardiouz-2024-1-00014}
}

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