Background. Uncontrolled arterial hypertension in patients at high and very high cardiovascular risk remains a significant issue in modern medicine. Optimizing antihypertensive therapy using fixed or separate combinations of drugs represents a promising approach to improving blood pressure control and reducing the risk of cardiovascular complications. Materials and methods. The study included 40 patients (men and women) with grade I–III hypertension according to the ESC/ESH classification (2018). The mean age was 51.52 ± 9.43 years, and the average disease duration was 8.52 ± 6.64 years. Patients were divided into two groups: one received a fixed combination (lisinopril/amlodipine/rosuvastatin), and the other received a separate combination (perindopril/amlodipine and rosuvastatin). Treatment lasted for 3 months. Effectiveness was assessed using 24-hour blood pressure monitoring, applanation tonometry, echocardiography, ultrasound examination of brachiocephalic arteries, and laboratory analyses (lipid profile, glucose level, uric acid, and creatinine). Results. Both therapy regimens demonstrated high antihypertensive, organoprotective, and hypolipidemic effectiveness. However, patients receiving the fixed combination showed a more significant reduction in systolic and diastolic blood pressure, improved lipid profile, and decreased nighttime blood pressure variability. No adverse effects on metabolic profiles were observed. Conclusion. The fixed combination of drugs demonstrated superiority over the separate combination regimen, providing better blood pressure control and lipid profile improvement. These findings highlight the importance of selecting optimal therapy regimens for high cardiovascular risk patients and confirm the efficacy of fixed combinations in this patient group.
| Mualliflar | Файзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina |
|---|---|
| Jurnal | O‘zbekiston кardiologiyasi |
| Nashr sanasi | 2024-06-23 |
| Jild | 1 |
| Son | 2 |
| Betlar | 122-131 |
| Til | Rus |
| DOI | 10.70626/cardiouz-2024-1-00015 |
DOI: 10.70626/cardiouz-2024-1-00015 · Maqolaning asl sahifasi
arterial hypertension, blood Pressure Control, ACE inhibitors, calcium channel blockers, statins, cardiovascular risk management, aртериальная гипертензия, контроль артериального давления, ингибиторы АПФ, блокаторы кальциевых каналов, статины, управление сердечно-сосудистым риском, arterial gipertenziya, qon bosimini nazorat qilish, AAF ingibitorlari, kaltsiy kanali blokatorlari, statinlar, yurak-qon tomir xavfini boshqarish
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