Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs

Файзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina

O‘zbekiston кardiologiyasi · 2024-yil

Annotatsiya

Background. Uncontrolled arterial hypertension in patients at high and very high cardiovascular risk remains a significant issue in modern medicine. Optimizing antihypertensive therapy using fixed or separate combinations of drugs represents a promising approach to improving blood pressure control and reducing the risk of cardiovascular complications. Materials and methods. The study included 40 patients (men and women) with grade I–III hypertension according to the ESC/ESH classification (2018). The mean age was 51.52 ± 9.43 years, and the average disease duration was 8.52 ± 6.64 years. Patients were divided into two groups: one received a fixed combination (lisinopril/amlodipine/rosuvastatin), and the other received a separate combination (perindopril/amlodipine and rosuvastatin). Treatment lasted for 3 months. Effectiveness was assessed using 24-hour blood pressure monitoring, applanation tonometry, echocardiography, ultrasound examination of brachiocephalic arteries, and laboratory analyses (lipid profile, glucose level, uric acid, and creatinine). Results. Both therapy regimens demonstrated high antihypertensive, organoprotective, and hypolipidemic effectiveness. However, patients receiving the fixed combination showed a more significant reduction in systolic and diastolic blood pressure, improved lipid profile, and decreased nighttime blood pressure variability. No adverse effects on metabolic profiles were observed. Conclusion. The fixed combination of drugs demonstrated superiority over the separate combination regimen, providing better blood pressure control and lipid profile improvement. These findings highlight the importance of selecting optimal therapy regimens for high cardiovascular risk patients and confirm the efficacy of fixed combinations in this patient group.

Maqola ma’lumotlari
MualliflarФайзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2024-06-23
Jild1
Son2
Betlar122-131
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2024-1-00015
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2024-1-00015 · Maqolaning asl sahifasi

Kalit so‘zlar

arterial hypertension, blood Pressure Control, ACE inhibitors, calcium channel blockers, statins, cardiovascular risk management, aртериальная гипертензия, контроль артериального давления, ингибиторы АПФ, блокаторы кальциевых каналов, статины, управление сердечно-сосудистым риском, arterial gipertenziya, qon bosimini nazorat qilish, AAF ingibitorlari, kaltsiy kanali blokatorlari, statinlar, yurak-qon tomir xavfini boshqarish

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAФайзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, & Yuldasheva , Alina (2024). Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs. O‘zbekiston кardiologiyasi, 1(2), 122-131. https://doi.org/10.70626/cardiouz-2024-1-00015
GOST (OAK)Файзуллаева, Ш va b. Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs // O‘zbekiston кardiologiyasi. – 2024. – T. 1, № 2. – P. 122-131. – DOI: 10.70626/cardiouz-2024-1-00015.
MLAФайзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, and Yuldasheva , Alina. “Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs.” O‘zbekiston кardiologiyasi, 1(2), 122-131, 2024. https://doi.org/10.70626/cardiouz-2024-1-00015
ChicagoФайзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, and Yuldasheva , Alina. “Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs.” O‘zbekiston кardiologiyasi, 1(2), 122-131 (2024). https://doi.org/10.70626/cardiouz-2024-1-00015
HarvardФайзуллаева, Ш, Хамидуллаева , Г, Абдуллаева , Г, Юсупова , Х, Бекметова , С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, Yuldasheva , Alina, Fayzullayeva, Shaxlo, Xamidullayeva , Gulnoza, Abdullayeva , Guzal, Yusupova , Hafiza, Bekmetova , Sevara, and Yuldasheva , Alina (2024) ‘Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs’, O‘zbekiston кardiologiyasi, 1(2), 122-131. https://doi.org/10.70626/cardiouz-2024-1-00015
BibTeX
@article{article2024,
  title = {Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs},
  author = {Файзуллаева, Ш and Хамидуллаева , Г and Абдуллаева , Г and Юсупова , Х and Бекметова , С and Юлдашева, А and Fayzullayeva, Shakhlo and Khamidullayeva , Gulnoza and Abdullayeva , Guzal and Yusupova , Hafiza and Bekmetova , Sevara and Yuldasheva , Alina and Fayzullayeva, Shaxlo and Xamidullayeva , Gulnoza and Abdullayeva , Guzal and Yusupova , Hafiza and Bekmetova , Sevara and Yuldasheva , Alina},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2024},
  volume = {1},
  number = {2},
  pages = {122-131},
  doi = {10.70626/cardiouz-2024-1-00015},
  url = {https://doi.org/10.70626/cardiouz-2024-1-00015}
}

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