Features of thyroid status in children and adolescents with graves' disease living in iodine-deficient conditions

Муратова Шахло Тахиржановна, Алимов Анвар Валиевич

Марказий Осиё эндокринологик журнали · 2025-yil

Annotatsiya

Relevance. Graves' disease (GD) is a hereditary organ-specific autoimmune disorder. The incidence of GD in children has increased by 27.3-30.1% over the last 10-20 years, with a more pronounced rise in the last decade. However, there is currently no consensus on the impact of iodine deficiency on the development and severity of GD in children. Purpose. To assess the features of thyroid status in children and adolescents living in a region with moderate iodine deficiency. Materials and Methods: A total of 310 children aged 2 years 11 months to 18 years were examined, divided into two groups: 213 patients with autoimmune endogenous hyperthyroidism with various morphological thyroid structures, and 97 relatively healthy children. Results: Diffuse toxic goiter (79.3%) was more frequently diagnosed in children with GD, while nodular goiter was observed in 12.2%, and multinodular goiter in 8.5% of children with hyperthyroidism. Among the latter, and Papillary thyroid cancer was confirmed in 3 children (42.9%) and follicular thyroid cancer in 4 children (57.1%). Girls were 3.8 times more likely to suffer from hyperthyroidism than boys, (p=0.004). 17.8% of children with GD had severe thyrotoxicosis. The mean levels of free T3 in children with hyperthyroidism living in an iodine-deficient region were 6 times higher, and free T4 levels were 4.6 times higher than in children without thyroid pathology. The mean levels of thyroid antibodies in children with hyperthyroidism indicated a pronounced autoimmune process in iodine-deficient conditions. In 79.5% of children with Graves' disease, anti-TSH receptor antibody levels were more than 5 times higher than normal. Conclusion. The data obtained indicate more severe courses of thyrotoxicosis, more frequent occurrence of nodular formations and thyroid cancer, and more pronounced autoimmune aggression in children living in iodine-deficient regions.

Maqola ma’lumotlari
MualliflarМуратова Шахло Тахиржановна, Алимов Анвар Валиевич
JurnalМарказий Осиё эндокринологик журнали
NashriyotРеспублика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази
ISSN2181-3426
Nashr sanasi2025-01-24
Jild4
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-06

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Kalit so‘zlar

щитовидная железа, гипертиреоз, болезнь Грейвса, дети, подростки, thyroid gland, hyperthyroidism, Graves' disease, children, adolescents, qalqonsimon bez, gipertiroidizm, Graves kasalligi, bolalar, o'smirlar

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Iqtibos keltirish

APAМуратова Шахло Тахиржановна, & Алимов Анвар Валиевич (2025). FEATURES OF THYROID STATUS IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE LIVING IN IODINE-DEFICIENT CONDITIONS. Марказий Осиё эндокринологик журнали, 4(3). https://www.tadqiqot.uz/index.php/cae/article/view/10740
GOST (OAK)Муратова Шахло Тахиржановна, Алимов Анвар Валиевич FEATURES OF THYROID STATUS IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE LIVING IN IODINE-DEFICIENT CONDITIONS // Марказий Осиё эндокринологик журнали. – 2025. – T. 4, № 3.
MLAМуратова Шахло Тахиржановна, and Алимов Анвар Валиевич. “FEATURES OF THYROID STATUS IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE LIVING IN IODINE-DEFICIENT CONDITIONS.” Марказий Осиё эндокринологик журнали, 4(3), 2025. https://www.tadqiqot.uz/index.php/cae/article/view/10740
ChicagoМуратова Шахло Тахиржановна, and Алимов Анвар Валиевич. “FEATURES OF THYROID STATUS IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE LIVING IN IODINE-DEFICIENT CONDITIONS.” Марказий Осиё эндокринологик журнали, 4(3) (2025). https://www.tadqiqot.uz/index.php/cae/article/view/10740
HarvardМуратова Шахло Тахиржановна, and Алимов Анвар Валиевич (2025) ‘FEATURES OF THYROID STATUS IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE LIVING IN IODINE-DEFICIENT CONDITIONS’, Марказий Осиё эндокринологик журнали, 4(3). https://www.tadqiqot.uz/index.php/cae/article/view/10740
BibTeX
@article{article2025,
  title = {FEATURES OF THYROID STATUS IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE LIVING IN IODINE-DEFICIENT CONDITIONS},
  author = {Муратова Шахло Тахиржановна and Алимов Анвар Валиевич},
  journal = {Марказий Осиё эндокринологик журнали},
  year = {2025},
  volume = {4},
  number = {3},
  url = {https://www.tadqiqot.uz/index.php/cae/article/view/10740}
}

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