Prognostic significance of CD123 (IL3RA) expression in patients with acute leukemias

KAYUMOV Abdurakhman Abdumavlanovich, KAYUMOV Abdurakhman Abdumavlanovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

This study evaluated the clinical and prognostic significance of CD123 (IL3RA) expression in patients with acute leukemia. A total of 116 patients were included in this single-center observational study. CD123 expression in bone marrow blast cells was assessed by multiparameter flow cytometry and quantified as the percentage of CD123-positive cells. CD123 expression was detected in 79.3% of patients, with high expression (≥50%) observed in 68.1%. The highest levels were found in myeloid, myelomonocytic, and monoblastic variants.High CD123 expression was associated with increased bone marrow blast infiltration, aggressive disease course, primary resistance to therapy, and early relapse. A prognostic risk score incorporating CD123 expression, blast percentage, and leukemia subtype was developed and demonstrated acceptable predictive performance (AUC ≈0.74).The findings support the inclusion of CD123 in routine immunophenotyping panels and highlight its role as a prognostic biomarker for risk stratification and individualized therapeutic decision-making in acute leukemia.

Maqola ma’lumotlari
MualliflarKAYUMOV Abdurakhman Abdumavlanovich, KAYUMOV Abdurakhman Abdumavlanovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-06
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

CD123, интерлейкин-3, острый миелоидный лейкоз, острый лимфобластный лейкоз., CD123, interleukin-3, acute lymphoblastic leukemia, acute myeloid leukemia, CD123, interleykin-3, o‘tkir limfoblast leykoz, o‘tkir miyeloid leykoz.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKAYUMOV Abdurakhman Abdumavlanovich, & KAYUMOV Abdurakhman Abdumavlanovich (2026). PROGNOSTIC SIGNIFICANCE OF CD123 (IL3RA) EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIAS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13699
GOST (OAK)KAYUMOV Abdurakhman Abdumavlanovich, KAYUMOV Abdurakhman Abdumavlanovich PROGNOSTIC SIGNIFICANCE OF CD123 (IL3RA) EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIAS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLAKAYUMOV Abdurakhman Abdumavlanovich, and KAYUMOV Abdurakhman Abdumavlanovich. “PROGNOSTIC SIGNIFICANCE OF CD123 (IL3RA) EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIAS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13699
ChicagoKAYUMOV Abdurakhman Abdumavlanovich, and KAYUMOV Abdurakhman Abdumavlanovich. “PROGNOSTIC SIGNIFICANCE OF CD123 (IL3RA) EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIAS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13699
HarvardKAYUMOV Abdurakhman Abdumavlanovich, and KAYUMOV Abdurakhman Abdumavlanovich (2026) ‘PROGNOSTIC SIGNIFICANCE OF CD123 (IL3RA) EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIAS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13699
BibTeX
@article{kayumovabdurakhmanabdumavlanovich2026,
  title = {PROGNOSTIC SIGNIFICANCE OF CD123 (IL3RA) EXPRESSION IN PATIENTS WITH ACUTE LEUKEMIAS},
  author = {KAYUMOV Abdurakhman Abdumavlanovich and KAYUMOV Abdurakhman Abdumavlanovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13699}
}

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