Problems and prospects in the management of hemolytic anemias: a narrative review

LIPARTIA Mary Givievna, MUTALOVA Zumrad Sanzhar kizi

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective: To systematize current evidence on diagnostic and therapeutic challenges in hemolytic anemias (HA) of various origins, identify key contradictions in existing approaches, and outline directions for further research. Methods: A narrative literature review was conducted covering the period 2020–2026 using PubMed, Scopus, and Google Scholar databases. Search queries included: "hemolytic anemia diagnosis," "autoimmune hemolytic anemia treatment," "hereditary spherocytosis," "paroxysmal nocturnal hemoglobinuria," "warm autoimmune hemolytic anemia." Twenty-one sources meeting inclusion criteria were selected: original studies, systematic reviews, and clinical guidelines.Results: The diagnosis of HA remains a multi-layered challenge: the direct antiglobulin test (DAT) yields false-negative results in 2–11% of autoimmune HA (AIHA) cases, and differential diagnosis between hereditary and acquired forms frequently takes months. Glucocorticosteroid (GCS) therapy for AIHA is effective in 70–85% of patients in the short term, yet relapse occurs in 30–40%. Rituximab and newer targeted agents — complement inhibitors and anti-CD38 — are reshaping the therapeutic landscape, but the evidence base for several HA subtypes remains limited. Molecular genetic methods in hereditary HA are being adopted unevenly. Conclusions: Hemolytic anemias are a heterogeneous group of conditions for which a unified diagnostic algorithm is not applicable. Prospective multicenter studies, standardization of laboratory protocols, and the development of personalized therapeutic strategies are required.

Maqola ma’lumotlari
MualliflarLIPARTIA Mary Givievna, MUTALOVA Zumrad Sanzhar kizi
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-06
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

гемолитическая анемия, аутоиммунная гемолитическая анемия, прямой антиглобулиновый тест, ритуксимаб, пароксизмальная ночная гемоглобинурия, наследственный сфероцитоз, ингибиторы комплемента, дифференциальная диагностика, hemolytic anemia, autoimmune hemolytic anemia, direct antiglobulin test, rituximab, paroxysmal nocturnal hemoglobinuria, hereditary spherocytosis, complement inhibitors, differential diagnosis., gemolitik anemiya, autoimmun gemolitik anemiya, to‘g‘ridan-to‘g‘ri antiglobulin testi, rituksimab, paroksizmal tungi gemoglobinuriya, irsiy sferotsitoz, komplement ingibitorlari, differensial diagnostika

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Tibbiyot

Iqtibos keltirish

APALIPARTIA Mary Givievna, & MUTALOVA Zumrad Sanzhar kizi (2026). PROBLEMS AND PROSPECTS IN THE MANAGEMENT OF HEMOLYTIC ANEMIAS: A NARRATIVE REVIEW. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13698
GOST (OAK)LIPARTIA Mary Givievna, MUTALOVA Zumrad Sanzhar kizi PROBLEMS AND PROSPECTS IN THE MANAGEMENT OF HEMOLYTIC ANEMIAS: A NARRATIVE REVIEW // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLALIPARTIA Mary Givievna, and MUTALOVA Zumrad Sanzhar kizi. “PROBLEMS AND PROSPECTS IN THE MANAGEMENT OF HEMOLYTIC ANEMIAS: A NARRATIVE REVIEW.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13698
ChicagoLIPARTIA Mary Givievna, and MUTALOVA Zumrad Sanzhar kizi. “PROBLEMS AND PROSPECTS IN THE MANAGEMENT OF HEMOLYTIC ANEMIAS: A NARRATIVE REVIEW.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13698
HarvardLIPARTIA Mary Givievna, and MUTALOVA Zumrad Sanzhar kizi (2026) ‘PROBLEMS AND PROSPECTS IN THE MANAGEMENT OF HEMOLYTIC ANEMIAS: A NARRATIVE REVIEW’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13698
BibTeX
@article{lipartiamarygivievna2026,
  title = {PROBLEMS AND PROSPECTS IN THE MANAGEMENT OF HEMOLYTIC ANEMIAS: A NARRATIVE REVIEW},
  author = {LIPARTIA Mary Givievna and MUTALOVA Zumrad Sanzhar kizi},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13698}
}

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