Immune microenvironment of soft tissue sarcomas: the role of t-lymphocytes and macrophages in predicting therapy efficacy

KARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, KARIMOVA Nargiza Mansurovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

This article is devoted to the study of the role of components of the immune microenvironment of soft tissue sarcomas, such as T-lymphocytes (CD4+, CD8+) and macrophages (CD68+), and their localization inside tumor structures. The analysis allows us to identify the relationship between the activity and localization of these immune cells and the degree of therapeutic pathomorphosis, which serves as an important prognostic marker. The results indicate that active immune infiltrates inside the tumor contribute to more pronounced morphological regression and a high degree of pathomorphosis, which correlates with positive therapeutic outcomes. At the same time, the study of localization patterns and status of immune cells provides new opportunities for prognostic assessment and development of personalized immunotherapeutic strategies. The data obtained emphasize that the parameters of the immune microenvironment can become an important tool in optimizing the treatment of soft tissue sarcomas and increasing their effectiveness.

Maqola ma’lumotlari
MualliflarKARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, KARIMOVA Nargiza Mansurovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-11-01
Jild10
Son4
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

саркома, Т-лимфоцит, микроокружение, химиотерапия, sarcoma, T-lymphocyte, microenvironment, chemotherapy, sarkoma, T-limfotsit, mikromuhit, kimyoterapiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, & KARIMOVA Nargiza Mansurovna (2025). IMMUNE MICROENVIRONMENT OF SOFT TISSUE SARCOMAS: THE ROLE OF T-LYMPHOCYTES AND MACROPHAGES IN PREDICTING THERAPY EFFICACY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12694
GOST (OAK)KARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, KARIMOVA Nargiza Mansurovna IMMUNE MICROENVIRONMENT OF SOFT TISSUE SARCOMAS: THE ROLE OF T-LYMPHOCYTES AND MACROPHAGES IN PREDICTING THERAPY EFFICACY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 4.
MLAKARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, and KARIMOVA Nargiza Mansurovna. “IMMUNE MICROENVIRONMENT OF SOFT TISSUE SARCOMAS: THE ROLE OF T-LYMPHOCYTES AND MACROPHAGES IN PREDICTING THERAPY EFFICACY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12694
ChicagoKARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, and KARIMOVA Nargiza Mansurovna. “IMMUNE MICROENVIRONMENT OF SOFT TISSUE SARCOMAS: THE ROLE OF T-LYMPHOCYTES AND MACROPHAGES IN PREDICTING THERAPY EFFICACY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12694
HarvardKARIMOVA Nargiza Mansurovna, KAHHAROV Alisher Jamoliddinovich, and KARIMOVA Nargiza Mansurovna (2025) ‘IMMUNE MICROENVIRONMENT OF SOFT TISSUE SARCOMAS: THE ROLE OF T-LYMPHOCYTES AND MACROPHAGES IN PREDICTING THERAPY EFFICACY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(4). https://tadqiqot.uz/index.php/biomedicine/article/view/12694
BibTeX
@article{karimovanargizamansurovna2025,
  title = {IMMUNE MICROENVIRONMENT OF SOFT TISSUE SARCOMAS: THE ROLE OF T-LYMPHOCYTES AND MACROPHAGES IN PREDICTING THERAPY EFFICACY},
  author = {KARIMOVA Nargiza Mansurovna and KAHHAROV Alisher Jamoliddinovich and KARIMOVA Nargiza Mansurovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {4},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12694}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2025-yil arxivi

KARIMOVA Nargiza Mansurovna — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari