The role of immune status in the pathogenesis of recurrent aphthous stomatitis

NAVRUZOVA Ugilxon Orzijon Qizi, XABIBOVA Nazira Nasulloevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

The article is devoted to the study of immune status in patients with recurrent aphthous stomatitis (RAS). An analysis of specific and nonspecific factors of local immune response, including lactoferrin, immunoglobulins (IgA, IgM, IgG), interferon-γ, interleukins (IL-2, IL-4), and tumor necrosis factor-α (TNF-α), was carried out. A significant increase in the concentrations of immunoglobulins and TNF-α was found, accompanied by a decrease in interferon-γ and IL-4. These changes indicate the activation of inflammatory processes, tissue destructive changes, and weakened antiviral protection of the mucosa. The obtained results emphasize the pathogenetic significance of local immunity in the development of RAS and substantiate the need to include immunomodulatory therapy in comprehensive treatment.

Maqola ma’lumotlari
MualliflarNAVRUZOVA Ugilxon Orzijon Qizi, XABIBOVA Nazira Nasulloevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-03-28
Jild10
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-13

Maqolaning asl sahifasi

Kalit so‘zlar

хронический рецидивирующий афтозный стоматит, иммунный статус, лактоферрин, интерлейкины, интерферон-γ, фактор некроза опухолей-α, иммуноглобулины, воспаление, локальный иммунитет, recurrent aphthous stomatitis, immune status, lactoferrin, interleukins, interferon-γ, tumor necrosis factor-α, immunoglobulins, inflammation, local immunity, retseptiv aftöz stomatit, immun maqomi, laktoferrin, interleykinlar, interferon-γ, o'sma nekroz omili-α, immunoglobulinlar, yallig'lanish, mahalliy immunitet

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APANAVRUZOVA Ugilxon Orzijon Qizi, & XABIBOVA Nazira Nasulloevna (2025). THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1). https://tadqiqot.uz/index.php/biomedicine/article/view/11172
GOST (OAK)NAVRUZOVA Ugilxon Orzijon Qizi, XABIBOVA Nazira Nasulloevna THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 1.
MLANAVRUZOVA Ugilxon Orzijon Qizi, and XABIBOVA Nazira Nasulloevna. “THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/11172
ChicagoNAVRUZOVA Ugilxon Orzijon Qizi, and XABIBOVA Nazira Nasulloevna. “THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/11172
HarvardNAVRUZOVA Ugilxon Orzijon Qizi, and XABIBOVA Nazira Nasulloevna (2025) ‘THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(1). https://tadqiqot.uz/index.php/biomedicine/article/view/11172
BibTeX
@article{navruzovaugilxonorzijonqizi2025,
  title = {THE ROLE OF IMMUNE STATUS IN THE PATHOGENESIS OF RECURRENT APHTHOUS STOMATITIS},
  author = {NAVRUZOVA Ugilxon Orzijon Qizi and XABIBOVA Nazira Nasulloevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/11172}
}

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