Stereochemical characteristics and biological activity of enantiomeric (r)- and (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES

Abdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., Pulatov, Elmurod Kh.

Товарлар кимёси ва халқ табобати · 2024-yil

Annotatsiya

The paper presents some visions of the reaction of formation of sulfur-containing heterocycles. In the case of five-membered structures of the thiazolidine heterocycle type, a thione-thiol tautomeric equilibrium occurs, associated with the migration of a proton between the endocyclic nitrogen atom and the exocyclic sulfur atom. Data on thermodynamic characteristics and information on the stability of various configuration states make it possible to plan further reactions, depending on the selected conditions for their implementation. Biological tests of racemic and optically active “4-methyl-4-ethyl-5-methylenethiazolidin-2-thiones” showed that they have different degrees of bacteriostatic and bactericidal action in relation to various strains of bacteria.

Maqola ma’lumotlari
MualliflarAbdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., Pulatov, Elmurod Kh.
JurnalТоварлар кимёси ва халқ табобати
NashriyotТабобат академияси
ISSN2181-2977
Nashr sanasi2024-10-18
Jild3
Son3
Betlar78-98
TilIngliz
Ilmiy sohaKimyo
DOI10.55475/jcgtm/vol3.iss3.2024.326
Indeksga qo‘shilgan2026-08-26

DOI: 10.55475/jcgtm/vol3.iss3.2024.326 · Maqolaning asl sahifasi

Kalit so‘zlar

Гетероциклы, таутомерия, ПМР спектроскопия, квантовохимический расчет, оптически активный тиазолидинтион, биологическая активность, Heterocycles, tautomerism, PMR spectroscopy, quantum chemical calculation, optically active thiazolidinthione, biological activity, Geterosikllar, tautomerizm, PMR spektroskopiyasi, kvant -imyoviy hisob, optik faol tiazolidintion, biologik faollik

Ilmiy soha

Kimyo

Iqtibos keltirish

APAAbdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., & Pulatov, Elmurod Kh. (2024). STEREOCHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF ENANTIOMERIC (R)- AND (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES. Товарлар кимёси ва халқ табобати, 3(3), 78-98. https://doi.org/10.55475/jcgtm/vol3.iss3.2024.326
GOST (OAK)Abdullaev, Tohir Kh. va b. STEREOCHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF ENANTIOMERIC (R)- AND (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES // Товарлар кимёси ва халқ табобати. – 2024. – T. 3, № 3. – P. 78-98. – DOI: 10.55475/jcgtm/vol3.iss3.2024.326.
MLAAbdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., and Pulatov, Elmurod Kh. “STEREOCHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF ENANTIOMERIC (R)- AND (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES.” Товарлар кимёси ва халқ табобати, 3(3), 78-98, 2024. https://doi.org/10.55475/jcgtm/vol3.iss3.2024.326
ChicagoAbdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., and Pulatov, Elmurod Kh. “STEREOCHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF ENANTIOMERIC (R)- AND (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES.” Товарлар кимёси ва халқ табобати, 3(3), 78-98 (2024). https://doi.org/10.55475/jcgtm/vol3.iss3.2024.326
HarvardAbdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., and Pulatov, Elmurod Kh (2024) ‘STEREOCHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF ENANTIOMERIC (R)- AND (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES’, Товарлар кимёси ва халқ табобати, 3(3), 78-98. https://doi.org/10.55475/jcgtm/vol3.iss3.2024.326
BibTeX
@article{abdullaevtohirkh2024,
  title = {STEREOCHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF ENANTIOMERIC (R)- AND (S)-4-METHYL-4-ETHYL-5-METHYLENETHIAZOLIDINES},
  author = {Abdullaev, Tohir Kh. and Askarov, Ibragim R. and Isobaev, Muzafar D. and Pulatov, Elmurod Kh.},
  journal = {Товарлар кимёси ва халқ табобати},
  year = {2024},
  volume = {3},
  number = {3},
  pages = {78-98},
  doi = {10.55475/jcgtm/vol3.iss3.2024.326},
  url = {https://doi.org/10.55475/jcgtm/vol3.iss3.2024.326}
}

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