The paper presents some visions of the reaction of formation of sulfur-containing heterocycles. In the case of five-membered structures of the thiazolidine heterocycle type, a thione-thiol tautomeric equilibrium occurs, associated with the migration of a proton between the endocyclic nitrogen atom and the exocyclic sulfur atom. Data on thermodynamic characteristics and information on the stability of various configuration states make it possible to plan further reactions, depending on the selected conditions for their implementation. Biological tests of racemic and optically active “4-methyl-4-ethyl-5-methylenethiazolidin-2-thiones” showed that they have different degrees of bacteriostatic and bactericidal action in relation to various strains of bacteria.
| Mualliflar | Abdullaev, Tohir Kh., Askarov, Ibragim R., Isobaev, Muzafar D., Pulatov, Elmurod Kh. |
|---|---|
| Jurnal | Товарлар кимёси ва халқ табобати |
| Nashr sanasi | 2024-10-18 |
| Jild | 3 |
| Son | 3 |
| Betlar | 78-98 |
| Til | O‘zbek |
| DOI | 10.55475/jcgtm/vol3.iss3.2024.326 |
DOI: 10.55475/jcgtm/vol3.iss3.2024.326 · Maqolaning asl sahifasi
Гетероциклы, таутомерия, ПМР спектроскопия, квантовохимический расчет, оптически активный тиазолидинтион, биологическая активность, Heterocycles, tautomerism, PMR spectroscopy, quantum chemical calculation, optically active thiazolidinthione, biological activity, Geterosikllar, tautomerizm, PMR spektroskopiyasi, kvant -imyoviy hisob, optik faol tiazolidintion, biologik faollik
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