Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome

Khatamov , Rustamjon, Hoshimov, Bobur, Хатамов, Р, Хошимов, Б, Xatamov , Rustamjon, Hoshimov, Bobur

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2026-yil

Annotatsiya

Aim. To characterize the morphology of the adrenal glands and thymus in preterm newborns who died from respiratory distress syndrome (RDS) and to assess their integrated interrelationship. Materials and Methods. A retrospective descriptive analysis was performed on adrenal and thymic tissues from 185 newborns with a gestational age of 26–32 weeks who underwent postmortem examination at the Fergana Regional Bureau of Pathological Anatomy between 2020 and 2024 (total sample N=185; clinically and morphologically confirmed RDS group n=155: 0–7 days n=95, 8–28 days n=60; non-RDS control group n=30). Tissue specimens were stained with hematoxylin and eosin. Quantitative data were expressed as M±m, and between-group differences were assessed using Student’s t-test (p<0.05). Results. The zona glomerulosa of the adrenal cortex remained in a primordial state in all cases, while lipid inclusions in spongiocytes of the zona fasciculata were sparse or absent. Venous congestion and diapedetic hemorrhages were observed in both the cortical and medullary layers in all cases. Mean adrenal gland weight was 2.08±0.3 g during the acute 0–7-day period and 3.05±0.04 g at 8–28 days, both significantly lower than the control value (4.01±0.05 g). Thymic weight was 4.05±0.06 g and 8.02±0.09 g, respectively, remaining below age-related norms but showing signs of compensatory enlargement relative to the severity of adrenal insufficiency (lymphocyte apoptosis: 54.8±0.05% at 0–7 days, 32.4±0.01% at 8–28 days; ≈5% in controls). In cases with a low Apgar score (0–3 points at 1 minute), regional mortality reached 70–80%; this figure was derived from regional clinical reports and was not calculated separately within the present study. Conclusion. Structural immaturity of the adrenal glands was accompanied by compensatory involutive-hyperplastic changes in the thymus and may represent an important morphological factor associated with mortality in neonatal RDS. Further controlled statistical studies are required to confirm this relationship.

Maqola ma’lumotlari
MualliflarKhatamov , Rustamjon, Hoshimov, Bobur, Хатамов, Р, Хошимов, Б, Xatamov , Rustamjon, Hoshimov, Bobur
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2026-06-29
Jild5
Son3
Betlar29-36
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/msu-2026-3-00016
Indeksga qo‘shilgan2026-09-26

DOI: 10.56121/msu-2026-3-00016 · Maqolaning asl sahifasi

Kalit so‘zlar

prematurity, respiratory distress syndrome, adrenal glands, thymus, pathomorphology, cortisol, недоношенность, респираторный дистресс-синдром, надпочечник, тимус, патоморфология, кортизол, chala tug‘ilish, respirator distress-sindrom, buyrak usti bezi timus, patomorfologiya kortizol

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKhatamov , Rustamjon, Hoshimov, Bobur, Хатамов, Р, Хошимов, Б, Xatamov , Rustamjon, & Hoshimov, Bobur (2026). Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 29-36. https://doi.org/10.56121/msu-2026-3-00016
GOST (OAK)Khatamov , Rustamjon va b. Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2026. – T. 5, № 3. – P. 29-36. – DOI: 10.56121/msu-2026-3-00016.
MLAKhatamov , Rustamjon, Hoshimov, Bobur, Хатамов, Р, Хошимов, Б, Xatamov , Rustamjon, and Hoshimov, Bobur. “Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 29-36, 2026. https://doi.org/10.56121/msu-2026-3-00016
ChicagoKhatamov , Rustamjon, Hoshimov, Bobur, Хатамов, Р, Хошимов, Б, Xatamov , Rustamjon, and Hoshimov, Bobur. “Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 29-36 (2026). https://doi.org/10.56121/msu-2026-3-00016
HarvardKhatamov , Rustamjon, Hoshimov, Bobur, Хатамов, Р, Хошимов, Б, Xatamov , Rustamjon, and Hoshimov, Bobur (2026) ‘Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 29-36. https://doi.org/10.56121/msu-2026-3-00016
BibTeX
@article{khatamovrustamjon2026,
  title = {Analysis of pathomorphological and morphometric changes in the organs of the adrenal-thymic system in newborns who died from respiratory distress syndrome},
  author = {Khatamov , Rustamjon and Hoshimov, Bobur and Хатамов, Р and Хошимов, Б and Xatamov , Rustamjon and Hoshimov, Bobur},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2026},
  volume = {5},
  number = {3},
  pages = {29-36},
  doi = {10.56121/msu-2026-3-00016},
  url = {https://doi.org/10.56121/msu-2026-3-00016}
}

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