Clinical and diagnostic significance of determining the glomerular filtration rate calculated using cystatin c in children and adolescents with type 1 diabetes mellitus in the uzbek population

Rakhimova , Gulnara, Alimova , Nasiba, Khalmatova , Kamola, Рахимова, Г, Алимова, Н, Халматова , К, Raximova , Gulnara, Alimova , Nasiba, Xalmatova , Kamola

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2026-yil

Annotatsiya

Objective. To comparatively evaluate the diagnostic performance of different methods for estimating glomerular filtration rate (GFR) in children and adolescents with type 1 diabetes mellitus (T1DM), depending on the stage of chronic kidney disease (CKD). Materials and Methods. This single-center cross-sectional study included 45 patients with T1DM (23 males and 22 females; median age, 15.5 years). Descriptive, correlation (Spearman), and regression analyses were performed. Results. A marked discrepancy was found in CKD stage distribution depending on the method used to calculate GFR. Based on creatinine, 88.4% of patients were classified as stage C1, whereas according to the CKiD 2012 formula, only 29.5% were classified as C1, 65.9% as C2, and 4.5% as C3a. HbA1c (β=2.719; p=0.008) and TIR (β=0.222; p=0.015) were independent risk factors for GFR estimated by CKiD 2012 (R²=0.394). Conclusion. The study results showed that the CKiD 2012 formula demonstrated the highest diagnostic performance for cystatin C-based estimation of GFR.

Maqola ma’lumotlari
MualliflarRakhimova , Gulnara, Alimova , Nasiba, Khalmatova , Kamola, Рахимова, Г, Алимова, Н, Халматова , К, Raximova , Gulnara, Alimova , Nasiba, Xalmatova , Kamola
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2026-06-29
Jild5
Son3
Betlar53-61
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/msu-2026-3-00019
Indeksga qo‘shilgan2026-10-18

DOI: 10.56121/msu-2026-3-00019 · Maqolaning asl sahifasi

Kalit so‘zlar

type 1 diabetes mellitus, glomerular filtration rate, cystatin C, HbA1c, TIR, chronic kidney disease, diabetic nephropathy, сахарный диабет 1 типа, скорость клубочковой фильтрации, цистатин С, HbA1c, TIR, хроническая болезнь почек, диабетическая нефропатия, 1-tur qandli diabet, glomerulyar filtratsiya tezligi, sistatin C, HbA1c, TIR, surunkali buyrak kasalligi, diabetik nefropatiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARakhimova , Gulnara, Alimova , Nasiba, Khalmatova , Kamola, Рахимова, Г, Алимова, Н, Халматова , К, Raximova , Gulnara, Alimova , Nasiba, & Xalmatova , Kamola (2026). CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 53-61. https://doi.org/10.56121/msu-2026-3-00019
GOST (OAK)Rakhimova , Gulnara va b. CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2026. – T. 5, № 3. – P. 53-61. – DOI: 10.56121/msu-2026-3-00019.
MLARakhimova , Gulnara, Alimova , Nasiba, Khalmatova , Kamola, Рахимова, Г, Алимова, Н, Халматова , К, Raximova , Gulnara, Alimova , Nasiba, and Xalmatova , Kamola. “CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 53-61, 2026. https://doi.org/10.56121/msu-2026-3-00019
ChicagoRakhimova , Gulnara, Alimova , Nasiba, Khalmatova , Kamola, Рахимова, Г, Алимова, Н, Халматова , К, Raximova , Gulnara, Alimova , Nasiba, and Xalmatova , Kamola. “CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 53-61 (2026). https://doi.org/10.56121/msu-2026-3-00019
HarvardRakhimova , Gulnara, Alimova , Nasiba, Khalmatova , Kamola, Рахимова, Г, Алимова, Н, Халматова , К, Raximova , Gulnara, Alimova , Nasiba, and Xalmatova , Kamola (2026) ‘CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(3), 53-61. https://doi.org/10.56121/msu-2026-3-00019
BibTeX
@article{rakhimovagulnara2026,
  title = {CLINICAL AND DIAGNOSTIC SIGNIFICANCE OF DETERMINING THE GLOMERULAR FILTRATION RATE CALCULATED USING CYSTATIN C IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS IN THE UZBEK POPULATION},
  author = {Rakhimova , Gulnara and Alimova , Nasiba and Khalmatova , Kamola and Рахимова, Г and Алимова, Н and Халматова , К and Raximova , Gulnara and Alimova , Nasiba and Xalmatova , Kamola},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2026},
  volume = {5},
  number = {3},
  pages = {53-61},
  doi = {10.56121/msu-2026-3-00019},
  url = {https://doi.org/10.56121/msu-2026-3-00019}
}

Boshqa maqola uchun iqtibos tayyorlash

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi jurnalidan boshqa maqolalar

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar · 2026-yil arxivi

Rakhimova , Gulnara — boshqa maqolalari

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari