Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study

Khoshimov, Bobur, Kenjaev, Sherzod, Хошимов, Бобур, Кенжаев, Ш, Hoshimov, Bobur, Kenjayev, Sherzod

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2026-yil

Annotatsiya

Aim. To characterise the morphological and morphometric changes of the pancreas, and their relationship with hepatic injury and pregnancy parity, in women who died with intrahepatic cholestasis of pregnancy (ICP).Materials and Methods. An autopsy-based morphological and quantitative morphometric study was performed on liver and pancreatic tissue from 51 women who died with severe ICP (Republican Scientific and Practical Center of Pathological Anatomy, 2013–2023), compared with 12 fertile-age controls who died of acute myocardial infarction. Sections were stained with haematoxylin–eosin and digitised for morphometry (12 parameters) in 28 index cases and controls; means were compared using Student’s t-test.Results. ICP livers showed centrilobular and midzonal hepatocellular cholestasis, bile-pigment accumulation, hydropic dystrophy and necrobiosis (54.2%), with canalicular bile stasis in 75% of cases. The pancreas showed bile reflux into major and lobular ducts, segmental acinar necrosis, vacuolar dystrophy, interstitial oedema, periductal infiltration and progressive fibrosis. All 12 morphometric indices differed significantly from controls (P<0.01–P<0.001), and severity increased with parity, being most pronounced in the third and fourth pregnancies.Conclusion. ICP is a systemic, bile-acid-mediated toxic condition producing quantifiable, parity-dependent pancreatic injury alongside hepatic cholestasis, supporting closer pancreatic surveillance in severe or recurrent ICP.

Maqola ma’lumotlari
MualliflarKhoshimov, Bobur, Kenjaev, Sherzod, Хошимов, Бобур, Кенжаев, Ш, Hoshimov, Bobur, Kenjayev, Sherzod
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2026-04-30
Jild5
Son2
Betlar74-82
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/msu-2026-2-00012
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/msu-2026-2-00012 · Maqolaning asl sahifasi

Kalit so‘zlar

intrahepatic cholestasis of pregnancy, pancreas, liver, morphometry, parity, bile acids, autopsy, pancreatitis, islets of Langerhans, histopathology, внутрипечёночный холестаз беременных, поджелудочная железа, печень, морфометрия, паритет, жёлчные кислоты, аутопсия, панкреатит, островки Лангерганса, гистопатология, homiladorlikdagi jigar ichi xolestazi, oshqozon osti bezi, jigar, morfometriya, paritet, o‘t kislotalari, autopsiya, pankreatit, Langergans orolchalari, gistopatologiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKhoshimov, Bobur, Kenjaev, Sherzod, Хошимов, Бобур, Кенжаев, Ш, Hoshimov, Bobur, & Kenjayev, Sherzod (2026). Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 74-82. https://doi.org/10.56121/msu-2026-2-00012
GOST (OAK)Khoshimov, Bobur va b. Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2026. – T. 5, № 2. – P. 74-82. – DOI: 10.56121/msu-2026-2-00012.
MLAKhoshimov, Bobur, Kenjaev, Sherzod, Хошимов, Бобур, Кенжаев, Ш, Hoshimov, Bobur, and Kenjayev, Sherzod. “Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 74-82, 2026. https://doi.org/10.56121/msu-2026-2-00012
ChicagoKhoshimov, Bobur, Kenjaev, Sherzod, Хошимов, Бобур, Кенжаев, Ш, Hoshimov, Bobur, and Kenjayev, Sherzod. “Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 74-82 (2026). https://doi.org/10.56121/msu-2026-2-00012
HarvardKhoshimov, Bobur, Kenjaev, Sherzod, Хошимов, Бобур, Кенжаев, Ш, Hoshimov, Bobur, and Kenjayev, Sherzod (2026) ‘Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 74-82. https://doi.org/10.56121/msu-2026-2-00012
BibTeX
@article{khoshimovbobur2026,
  title = {Parity-Dependent Pancreatic Morphological and Morphometric Changes in Intrahepatic Cholestasis of Pregnancy: An Autopsy Study},
  author = {Khoshimov, Bobur and Kenjaev, Sherzod and Хошимов, Бобур and Кенжаев, Ш and Hoshimov, Bobur and Kenjayev, Sherzod},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2026},
  volume = {5},
  number = {2},
  pages = {74-82},
  doi = {10.56121/msu-2026-2-00012},
  url = {https://doi.org/10.56121/msu-2026-2-00012}
}

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