Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study

Latibjonov, Azizbek, Musaeva, Yulduz, Латибжонов, Азизбек, Мусаева, Юлдуз, Latibjonov, Azizbek, Musayeva, Yulduz

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2026-yil

Annotatsiya

Aim. To characterise and compare the pathomorphological changes of peripancreatic (regional) and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis, and to define the structural correlates of their impaired immunopoietic and barrier–filtration functions. Materials and methods. Peripancreatic and mesenteric lymph nodes obtained at autopsy from decedents with a clinically and anamnestically confirmed history of chronic alcohol misuse were examined. Sections were stained with haematoxylin–eosin, van Gieson and alcian blue, and assessed semi-quantitatively across four morphofunctional compartments (capsule and sinuses, cortex, paracortex, medulla). Results. Acute forms were dominated by massive interstitial oedema involving all compartments, subcapsular and intermediate sinus dilatation, capsular disorganisation with fibre destruction, and sequestration of cortical lymphoid follicles. Chronic forms showed parenchymal atrophy with reciprocal proliferation and sclerosis of stromal–vascular structures, capsular thickening, medullary neoangiogenesis, sinus histiocytosis with plasmacytic and fibroblastic accumulation, and reticulosclerosis. In both groups paracortical postcapillary venules lost their high-endothelial phenotype and converted to thin-walled congested veins without transmural lymphocyte migration, and the reticular cell–lymphocyte symbiosis was disrupted. Conclusion. Alcoholic pancreatitis induces a stage-dependent, non-infectious lymphadenopathy that progresses from oedematous–destructive to atrophic–sclerotic remodelling, providing a structural basis for the impaired regional immune response and lymphatic drainage that accompany the disease.

Maqola ma’lumotlari
MualliflarLatibjonov, Azizbek, Musaeva, Yulduz, Латибжонов, Азизбек, Мусаева, Юлдуз, Latibjonov, Azizbek, Musayeva, Yulduz
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2026-04-30
Jild5
Son2
Betlar61-73
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/msu-2026-2-00011
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/msu-2026-2-00011 · Maqolaning asl sahifasi

Kalit so‘zlar

pancreatitis, alcoholic, lymph nodes, autopsy, fibrosis, immunity, cellular, pathology, панкреатит, алкогольный, лимфатические узлы, аутопсия, фиброз, иммунитет, клеточный, патология, pankreatit, alkogolli, limfa tugunlari, autopsiya, fibroz, immunitet, hujayraviy, patologiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APALatibjonov, Azizbek, Musaeva, Yulduz, Латибжонов, Азизбек, Мусаева, Юлдуз, Latibjonov, Azizbek, & Musayeva, Yulduz (2026). Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 61-73. https://doi.org/10.56121/msu-2026-2-00011
GOST (OAK)Latibjonov, Azizbek va b. Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2026. – T. 5, № 2. – P. 61-73. – DOI: 10.56121/msu-2026-2-00011.
MLALatibjonov, Azizbek, Musaeva, Yulduz, Латибжонов, Азизбек, Мусаева, Юлдуз, Latibjonov, Azizbek, and Musayeva, Yulduz. “Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 61-73, 2026. https://doi.org/10.56121/msu-2026-2-00011
ChicagoLatibjonov, Azizbek, Musaeva, Yulduz, Латибжонов, Азизбек, Мусаева, Юлдуз, Latibjonov, Azizbek, and Musayeva, Yulduz. “Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 61-73 (2026). https://doi.org/10.56121/msu-2026-2-00011
HarvardLatibjonov, Azizbek, Musaeva, Yulduz, Латибжонов, Азизбек, Мусаева, Юлдуз, Latibjonov, Azizbek, and Musayeva, Yulduz (2026) ‘Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 5(2), 61-73. https://doi.org/10.56121/msu-2026-2-00011
BibTeX
@article{latibjonovazizbek2026,
  title = {Pathomorphology of regional and mesenteric lymph nodes in acute and chronic alcoholic pancreatitis: a comparative autopsy study},
  author = {Latibjonov, Azizbek and Musaeva, Yulduz and Латибжонов, Азизбек and Мусаева, Юлдуз and Latibjonov, Azizbek and Musayeva, Yulduz},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2026},
  volume = {5},
  number = {2},
  pages = {61-73},
  doi = {10.56121/msu-2026-2-00011},
  url = {https://doi.org/10.56121/msu-2026-2-00011}
}

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