Helicobacter pylori-associated gastric and duodenal ulcer disease and vitamin d deficiency: the problem in the interpretation of the literature

Ashurova N.G, Ismatova M.N, Ismoilova M.S

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

This scientific article analyzes the clinical course of gastric and duodenal ulcer disease associated with Helicobacter pylori under conditions of vitamin D deficiency. Research findings indicate that patients with low serum levels of 25(OH)D have a higher risk of eradication therapy failure. Furthermore, polymorphisms of the VDR gene, including FokI, BsmI, ApaI, and TaqI, have been shown to influence susceptibility to Helicobacter pylori infection, the course of the inflammatory process, and treatment outcomes. This article comprehensively discusses the role of vitamin D deficiency in the pathogenesis of Helicobacter pylori infection, its impact on the clinical manifestations of gastroduodenal ulcer disease, and modern approaches to eradication therapy based on both Uzbek and international scientific literature.

Maqola ma’lumotlari
MualliflarAshurova N.G, Ismatova M.N, Ismoilova M.S
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-09-08
Jild3
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-09

Maqolaning asl sahifasi

Kalit so‘zlar

Helicobacter pylori, vitamin D, 25(OH)D, VDR polymorphism, cathelicidin, β-defensin, eradication, antimicrobial peptides, mucosal immunity, peptic ulcer disease, clinical course, Uzbekistan., Helicobacter pylori, витамин D, 25(OH)D, полиморфизм VDR, кателицидин, β-дефензин, эрадикация, антимикробные пептиды, мукозальный иммунитет, язвенная болезнь, клиническое течение, Узбекистан, Helicobacter pylori, D vitamini, 25(OH)D, VDR polimorfizmi, katelisidin, β-defensin, eradikatsiya, antimikrobial peptidlar, mukosal immunitet, yara kasalligi, klinik kechish, O'zbekiston

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAshurova N.G, Ismatova M.N, & Ismoilova M.S (2026). HELICOBACTER PYLORI-ASSOCIATED GASTRIC AND DUODENAL ULCER DISEASE AND VITAMIN D DEFICIENCY: THE PROBLEM IN THE INTERPRETATION OF THE LITERATURE. Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14988
GOST (OAK)Ashurova N.G, Ismatova M.N, Ismoilova M.S HELICOBACTER PYLORI-ASSOCIATED GASTRIC AND DUODENAL ULCER DISEASE AND VITAMIN D DEFICIENCY: THE PROBLEM IN THE INTERPRETATION OF THE LITERATURE // Klinik fanlar yilnomasi. – 2026. – T. 3, № 2.
MLAAshurova N.G, Ismatova M.N, and Ismoilova M.S. “HELICOBACTER PYLORI-ASSOCIATED GASTRIC AND DUODENAL ULCER DISEASE AND VITAMIN D DEFICIENCY: THE PROBLEM IN THE INTERPRETATION OF THE LITERATURE.” Klinik fanlar yilnomasi, 3(2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/14988
ChicagoAshurova N.G, Ismatova M.N, and Ismoilova M.S. “HELICOBACTER PYLORI-ASSOCIATED GASTRIC AND DUODENAL ULCER DISEASE AND VITAMIN D DEFICIENCY: THE PROBLEM IN THE INTERPRETATION OF THE LITERATURE.” Klinik fanlar yilnomasi, 3(2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/14988
HarvardAshurova N.G, Ismatova M.N, and Ismoilova M.S (2026) ‘HELICOBACTER PYLORI-ASSOCIATED GASTRIC AND DUODENAL ULCER DISEASE AND VITAMIN D DEFICIENCY: THE PROBLEM IN THE INTERPRETATION OF THE LITERATURE’, Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14988
BibTeX
@article{ashurovang2026,
  title = {HELICOBACTER PYLORI-ASSOCIATED GASTRIC AND DUODENAL ULCER DISEASE AND VITAMIN D DEFICIENCY: THE PROBLEM IN THE INTERPRETATION OF THE LITERATURE},
  author = {Ashurova N.G and Ismatova M.N and Ismoilova M.S},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/14988}
}

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