Significance of serum markers of the proinflammatory cytokine cascade in the differential diagnosis of parkinsonian syndrome

Mansurova N.A

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

The article presents a comparative analysis of the pathogenetic features of systemic inflammatory reactions in degenerative and vascular forms of parkinsonism. The profile of proinflammatory cytokines was investigated as the central mediator of immune activation in relation to clinical and neurological manifestations of the disease and gastrointestinal triggers. Based on the results of statistical analysis, a qualitative polarity in the architecture of correlation profiles between the studied nosological groups was proven. The expression of proinflammatory cytokines in Parkinson's disease appears to be systemically intertwined with gut-related factors—specifically infectious invasion and localized mucosal immune activity—as well as clinical symptom severity. Conversely, gastrointestinal influences showed zero impact on cytokine concentrations in cases of vascular parkinsonism. Consequently, the inflammatory response in the vascular group can be classified as an autonomous vasogenic process stemming from endothelial damage and persistent brain hypoperfusion. It is concluded that in vascular parkinsonism, systemic cytokine pooling occurs in isolation from enteral triggers and has an autonomous vasogenic nature caused by chronic cerebral ischemia and endothelial dysfunction.

Maqola ma’lumotlari
MualliflarMansurova N.A
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-09-08
Jild3
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-09

Maqolaning asl sahifasi

Kalit so‘zlar

parkinsonism, proinflammatory cytokines, early diagnosis, differential diagnosis, паркинсонизм, провоспалительные цитокины, ранняя диагностика, дифференциальная диагностика, parkinsonizm, yallig‘lanisholdi sitokinlari, erta tashxislash, qiyosiy tashxislash

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMansurova N.A (2026). SIGNIFICANCE OF SERUM MARKERS OF THE PROINFLAMMATORY CYTOKINE CASCADE IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSONIAN SYNDROME. Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14993
GOST (OAK)Mansurova N.A SIGNIFICANCE OF SERUM MARKERS OF THE PROINFLAMMATORY CYTOKINE CASCADE IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSONIAN SYNDROME // Klinik fanlar yilnomasi. – 2026. – T. 3, № 2.
MLAMansurova N.A. “SIGNIFICANCE OF SERUM MARKERS OF THE PROINFLAMMATORY CYTOKINE CASCADE IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSONIAN SYNDROME.” Klinik fanlar yilnomasi, 3(2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/14993
ChicagoMansurova N.A. “SIGNIFICANCE OF SERUM MARKERS OF THE PROINFLAMMATORY CYTOKINE CASCADE IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSONIAN SYNDROME.” Klinik fanlar yilnomasi, 3(2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/14993
HarvardMansurova N.A (2026) ‘SIGNIFICANCE OF SERUM MARKERS OF THE PROINFLAMMATORY CYTOKINE CASCADE IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSONIAN SYNDROME’, Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14993
BibTeX
@article{mansurovana2026,
  title = {SIGNIFICANCE OF SERUM MARKERS OF THE PROINFLAMMATORY CYTOKINE CASCADE IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSONIAN SYNDROME},
  author = {Mansurova N.A},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/14993}
}

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