Cerebral ischemia: causes, developmental mechanisms and preventive approaches abstract

Rakhmatova S.N, Ashurova N.G, Umarova Sh.K, Sunnatova N.Z

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

This review consolidates contemporary evidence on the principal pathobiological pathways of ischemic stroke — encompassing thromboembolic occlusion, atherosclerotic plaque vulnerability, and microangiopathy of penetrating arteries — while critically appraising primary, secondary, and emerging preventive frameworks grounded in molecular evidence. Once cerebral perfusion reserve descends below 10 mL/100 g/min, aberrant neurotransmitter release is triggered, initiating a cascading pathochemical sequence: adenosine triphosphate depletion, impaired transmembrane ionic homeostasis, mitochondrial apoptotic activation, and necrobiotical cellular demise. Activation of the NLRP3 inflammasome, phenotypic reprogramming of resident microglia, and transendothelial migration of neutrophil granulocytes into cerebral parenchyma collectively drive progressive infarct core enlargement. Preventive interventions supported by rigorous clinical evidence encompass: systolic blood pressure reduction (yielding a 35–40% decline in stroke incidence), stabilization of atheromatous plaques via statins, administration of novel direct oral anticoagulants in atrial fibrillation (RE-LY and ROCKET-AF trials), and multidimensional risk factor management

Maqola ma’lumotlari
MualliflarRakhmatova S.N, Ashurova N.G, Umarova Sh.K, Sunnatova N.Z
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-09-08
Jild3
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-09

Maqolaning asl sahifasi

Kalit so‘zlar

ишемический инсульт; патобиологические механизмы; церебральная перфузия; эксайтотоксичность; нейропротекция; профилактика инсульта; атеросклероз; фибрилляция предсердий; микроангиопатия; цереброваскулярная патология, miya ishemiyasi; patobiologik mexanizmlar; serebral perfuziya; ekzitotoksiklik; neyroprotektsiya; insultni bartaraf etish; ateroskleroz; atrial fibrillyatsiya; mayda tomir kasalligi; serebrovaskulyar patologiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARakhmatova S.N, Ashurova N.G, Umarova Sh.K, & Sunnatova N.Z (2026). CEREBRAL ISCHEMIA: CAUSES, DEVELOPMENTAL MECHANISMS AND PREVENTIVE APPROACHES ABSTRACT. Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14997
GOST (OAK)Rakhmatova S.N va b. CEREBRAL ISCHEMIA: CAUSES, DEVELOPMENTAL MECHANISMS AND PREVENTIVE APPROACHES ABSTRACT // Klinik fanlar yilnomasi. – 2026. – T. 3, № 2.
MLARakhmatova S.N, Ashurova N.G, Umarova Sh.K, and Sunnatova N.Z. “CEREBRAL ISCHEMIA: CAUSES, DEVELOPMENTAL MECHANISMS AND PREVENTIVE APPROACHES ABSTRACT.” Klinik fanlar yilnomasi, 3(2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/14997
ChicagoRakhmatova S.N, Ashurova N.G, Umarova Sh.K, and Sunnatova N.Z. “CEREBRAL ISCHEMIA: CAUSES, DEVELOPMENTAL MECHANISMS AND PREVENTIVE APPROACHES ABSTRACT.” Klinik fanlar yilnomasi, 3(2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/14997
HarvardRakhmatova S.N, Ashurova N.G, Umarova Sh.K, and Sunnatova N.Z (2026) ‘CEREBRAL ISCHEMIA: CAUSES, DEVELOPMENTAL MECHANISMS AND PREVENTIVE APPROACHES ABSTRACT’, Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14997
BibTeX
@article{rakhmatovasn2026,
  title = {CEREBRAL ISCHEMIA: CAUSES, DEVELOPMENTAL MECHANISMS AND PREVENTIVE APPROACHES ABSTRACT},
  author = {Rakhmatova S.N and Ashurova N.G and Umarova Sh.K and Sunnatova N.Z},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/14997}
}

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