Pathomorphological and histological changes in the immune organs of newborns born to mothers with COVID-19 during pregnancy

Djumaniyazova N.S

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

This study explores pathomorphological and histological alterations in the immune organs of neonates following antenatal exposure to maternal SARS-CoV-2 infection. Particular attention is given to structural changes in primary and secondary lymphoid organs, including the thymus, spleen, and peripheral lymph nodes, which play a critical role in early immune competence. The findings suggest that the observed immune remodeling is predominantly driven by indirect mechanisms, namely maternal systemic inflammation and immune activation, rather than by direct transplacental viral transmission. Characteristic pathological features include accidental thymic involution, hypoplasia of the splenic white pulp, and attenuation of germinal center formation within lymph nodes. Collectively, these alterations reflect a state of functional immunological vulnerability in affected neonates, underscoring the need for individualized postnatal immunological monitoring and follow-up strategies.

Maqola ma’lumotlari
MualliflarDjumaniyazova N.S
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-09-08
Jild3
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-09

Maqolaning asl sahifasi

Kalit so‘zlar

SARS-CoV-2, neonatal immunity, thymic involution, lymphoid hypoplasia, histopathology, cytokine-mediated inflammation, SARS-CoV-2, неонатальный иммунитет, инволюция тимуса, гипоплазия лимфоидной ткани, гистопатология, цитокин-опосредованное воспаление, SARS-CoV-2, neonatal immunitet, timus involyutsiyasi, limfoid to‘qima gipoplaziyasi, gistopatologiya, sitokin vositachiligidagi yallig‘lanish

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APADjumaniyazova N.S (2026). PATHOMORPHOLOGICAL AND HISTOLOGICAL CHANGES IN THE IMMUNE ORGANS OF NEWBORNS BORN TO MOTHERS WITH COVID-19 DURING PREGNANCY. Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14992
GOST (OAK)Djumaniyazova N.S PATHOMORPHOLOGICAL AND HISTOLOGICAL CHANGES IN THE IMMUNE ORGANS OF NEWBORNS BORN TO MOTHERS WITH COVID-19 DURING PREGNANCY // Klinik fanlar yilnomasi. – 2026. – T. 3, № 2.
MLADjumaniyazova N.S. “PATHOMORPHOLOGICAL AND HISTOLOGICAL CHANGES IN THE IMMUNE ORGANS OF NEWBORNS BORN TO MOTHERS WITH COVID-19 DURING PREGNANCY.” Klinik fanlar yilnomasi, 3(2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/14992
ChicagoDjumaniyazova N.S. “PATHOMORPHOLOGICAL AND HISTOLOGICAL CHANGES IN THE IMMUNE ORGANS OF NEWBORNS BORN TO MOTHERS WITH COVID-19 DURING PREGNANCY.” Klinik fanlar yilnomasi, 3(2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/14992
HarvardDjumaniyazova N.S (2026) ‘PATHOMORPHOLOGICAL AND HISTOLOGICAL CHANGES IN THE IMMUNE ORGANS OF NEWBORNS BORN TO MOTHERS WITH COVID-19 DURING PREGNANCY’, Klinik fanlar yilnomasi, 3(2). https://tadqiqot.uz/index.php/spjacd/article/view/14992
BibTeX
@article{djumaniyazovans2026,
  title = {PATHOMORPHOLOGICAL AND HISTOLOGICAL CHANGES IN THE IMMUNE ORGANS OF NEWBORNS BORN TO MOTHERS WITH COVID-19 DURING PREGNANCY},
  author = {Djumaniyazova N.S},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {3},
  number = {2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/14992}
}

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