The paper presents the results of a comprehensive pharmaco-technological assessment of a new substance “Tiotsin”, a zinc coordination compound based on modified α-lipoic acid. Organoleptic properties, solubility and hygroscopicity were evaluated along with particle morphology (microscopy), particle-size distribution (sieve analysis), residual moisture, flowability, angle of repose, bulk and tapped density. In addition, the Carr’s compressibility index and the Hausner ratio were calculated. The substance was found to be slightly hygroscopic (0.8%) and characterized by low residual moisture (1.27%). Microscopic examination revealed predominantly amorphous-granular isometric particles and pronounced polydispersity, which may affect powder handling during solid dosage form development. Based on flowability parameters (angle of repose 31.5±2.3°, Carr’s index 9.4%, Hausner ratio 1.16), “Tiotsin” can be classified as a powder with good flow properties; however, the broad particle-size distribution supports the need for excipients and/or granulation to ensure robust manufacturing of solid dosage forms.
| Mualliflar | Ruhsora Zakirova, Shukurjon Matyaqubova, Avez Sharipov |
|---|---|
| Jurnal | Фармация ва фармакология |
| Nashriyot | Фармацевтика ТТИ |
| ISSN | 2181-3159, 2016-2022 |
| Nashr sanasi | 2026-04-20 |
| Jild | 1 |
| Son | 15 |
| Betlar | 53-60 |
| Til | Ingliz |
| DOI | 10.66657/phcc/vol1_iss6-15/art8 |
| Indeksga qo‘shilgan | 2026-09-02 |
DOI: 10.66657/phcc/vol1_iss6-15/art8 · Maqolaning asl sahifasi · PDF
| APA | Ruhsora Zakirova, Shukurjon Matyaqubova, & Avez Sharipov (2026). STUDY OF PHARMACO-TECHNOLOGICAL PARAMETERS OF MODIFIED LIPOIC ACID. Фармация ва фармакология, 1(15), 53-60. https://doi.org/10.66657/phcc/vol1_iss6-15/art8 |
|---|---|
| GOST (OAK) | Ruhsora Zakirova, Shukurjon Matyaqubova, Avez Sharipov STUDY OF PHARMACO-TECHNOLOGICAL PARAMETERS OF MODIFIED LIPOIC ACID // Фармация ва фармакология. – 2026. – T. 1, № 15. – P. 53-60. – DOI: 10.66657/phcc/vol1_iss6-15/art8. |
| MLA | Ruhsora Zakirova, Shukurjon Matyaqubova, and Avez Sharipov. “STUDY OF PHARMACO-TECHNOLOGICAL PARAMETERS OF MODIFIED LIPOIC ACID.” Фармация ва фармакология, 1(15), 53-60, 2026. https://doi.org/10.66657/phcc/vol1_iss6-15/art8 |
| Chicago | Ruhsora Zakirova, Shukurjon Matyaqubova, and Avez Sharipov. “STUDY OF PHARMACO-TECHNOLOGICAL PARAMETERS OF MODIFIED LIPOIC ACID.” Фармация ва фармакология, 1(15), 53-60 (2026). https://doi.org/10.66657/phcc/vol1_iss6-15/art8 |
| Harvard | Ruhsora Zakirova, Shukurjon Matyaqubova, and Avez Sharipov (2026) ‘STUDY OF PHARMACO-TECHNOLOGICAL PARAMETERS OF MODIFIED LIPOIC ACID’, Фармация ва фармакология, 1(15), 53-60. https://doi.org/10.66657/phcc/vol1_iss6-15/art8 |
| BibTeX | @article{ruhsorazakirova2026,
title = {STUDY OF PHARMACO-TECHNOLOGICAL PARAMETERS OF MODIFIED LIPOIC ACID},
author = {Ruhsora Zakirova and Shukurjon Matyaqubova and Avez Sharipov},
journal = {Фармация ва фармакология},
year = {2026},
volume = {1},
number = {15},
pages = {53-60},
doi = {10.66657/phcc/vol1_iss6-15/art8},
url = {https://doi.org/10.66657/phcc/vol1_iss6-15/art8}
} |
Boshqa maqola uchun iqtibos tayyorlash
In this study, the lipid composition of the leaves of Senna angustifolia Vahl (Fabaceae), collected in May 2024 in the Surkhandarya region, was studied. Dried and ground leaf raw material was used for the study, in…
The pharmacological activity (hypoglycemic and other) of polysaccharides from the aerial parts of the Heliotropium plant (H. lasiocarpum, a member of the Boraginaceae family) has been studied for the first time. In vivo…
The article presents the results of quantitative determination of biologically active substances and microscopic analys of a medicinal herbal collection, including chamomile flowers, the herb of St. John’s wort, purple…
The wound-healing effects of gels prepared from ethyl acetate fractions, obtained from the aerial parts of Stachys hissarica and Stachys betoniciflora, were studied experimentally. To evaluate the wound-healing activity…
This review highlights the role of iodine deficiency and micronutrient deficiencies in the development of bone tissue disorders. Despite numerous studies, osteoporosis and osteopenia remain a pressing issue and remain…
The article presents a systematic analysis of the biochemical and phytochemical composition of citrus fruits, from the point of view of biologically active substances, and substantiates the need for an integrated…
Experimental studies have revealed that the compound 4-(6-phenyl-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazine-3-yl)-aniline, called epitriazoline, has high anticonvulsant activity when administered orally to…
This study is aimed at scientifically substantiating the biological activity of walnut (Juglans regia L.) raw material based on its vitamin and macro- and microelement composition. The results showed that the raw…
The article analyzes the dynamics of seasonal fluctuations in the volume of domestically produced and imported systemic antibacterial drugs of the pharmaceutical market of the Republic of Uzbekistan (group J01 according…
In this work, the psychopharmacological properties of the alkaloid 1-(3-hydroxy-4 methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline were studied under experimental conditions. According to the results, the…
Фармация ва фармакология — barcha maqolalar · 2026-yil arxivi