Chronic carbon monoxide exposure induces persistent tissue hypoxia and leads to structural and functional alterations, particularly in metabolically active organs. The kidney is highly susceptible to oxygen deficiency; therefore, prolonged hypoxia results in glomerular remodeling, tubular epithelial injury, microcirculatory disturbances, and interstitial alterations. The aim of this study was to comprehensively evaluate morphological and immunohistochemical changes in renal tissue following chronic carbon monoxide exposure. The experiment was conducted on 3- and 9-month-old male albino rats. Histological, morphometric, and immunohistochemical examinations were performed, and HIF-1α expression was assessed using digital image analysis. The findings demonstrated glomerular structural remodeling, morphological alterations of Bowman's capsule, dystrophic changes in proximal and distal tubular epithelium, interstitial edema, and impaired microcirculation. Immunohistochemical analysis revealed a significant increase in HIF-1α expression, indicating activation of hypoxia-related molecular pathways and reflecting the severity of renal tissue injury induced by chronic carbon monoxide exposure.
| Mualliflar | I.A. Mirkhodjaev, I.S. Khamrоev |
|---|---|
| Jurnal | Zamonaviy tibbiyot jurnali / Journal of modern medicine |
| Nashriyot | Андижон давлат тиббиёт институти |
| ISSN | 2992-8958 |
| Nashr sanasi | 2026-07-10 |
| Jild | 14 |
| Son | 3 |
| Betlar | 178-184 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| DOI | 10.67519/nshr.ztj.2026.03.035 |
| Indeksga qo‘shilgan | 2026-09-02 |
DOI: 10.67519/nshr.ztj.2026.03.035 · Maqolaning asl sahifasi · PDF
| APA | I.A. Mirkhodjaev, & I.S. Khamrоev (2026). MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 178-184. https://doi.org/10.67519/nshr.ztj.2026.03.035 |
|---|---|
| GOST (OAK) | I.A. Mirkhodjaev, I.S. Khamrоev MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 178-184. – DOI: 10.67519/nshr.ztj.2026.03.035. |
| MLA | I.A. Mirkhodjaev, and I.S. Khamrоev. “MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 178-184, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.035 |
| Chicago | I.A. Mirkhodjaev, and I.S. Khamrоev. “MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 178-184 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.035 |
| Harvard | I.A. Mirkhodjaev, and I.S. Khamrоev (2026) ‘MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 178-184. https://doi.org/10.67519/nshr.ztj.2026.03.035 |
| BibTeX | @article{iamirkhodjaev2026,
title = {MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES IN RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE},
author = {I.A. Mirkhodjaev and I.S. Khamrоev},
journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
year = {2026},
volume = {14},
number = {3},
pages = {178-184},
doi = {10.67519/nshr.ztj.2026.03.035},
url = {https://doi.org/10.67519/nshr.ztj.2026.03.035}
} |
Boshqa maqola uchun iqtibos tayyorlash
This scientific article investigates the diagnostic significance of immunoinflammatory biomarkers, cervical changes, and infectious factors in the early prediction of preterm birth risk in pregnant women. The study…
A sociological study was conducted to assess nutrition-related knowledge, attitudes toward school meals, and food preferences among students of general education schools. The study was carried out in five general…
Transcatheter closure of septal heart defects in children has long ceased to be an experimental technique – today it is a routine alternative to open surgery. However, the risk of developing acute and subacute heart…
This article presents the long-term results of a study on the dynamics of changes in the total microbial count (TMC) and coliform bacteria (CB) indicators in drinking water across the districts of the Bukhara region…
The development and evaluation of novel agents with antipyretic activity remain a priority in experimental pharmacology, particularly with regard to the development of safe and effective therapeutic strategies for the…
The aim of this study was to evaluate the clinical significance of Bispectral Index (BIS) monitoring for objective assessment of anesthesia depth in children undergoing surgical correction of congenital heart defects…
Chronic carbon monoxide exposure results in persistent tissue hypoxia and induces structural alterations in renal tissue, particularly within the glomerular and tubular compartments of the nephron. The present study…
Dental implantation has become one of the most effective methods for restoring missing teeth and improving patients’ quality of life. However, patients with diabetes mellitus represent a special clinical group due to…
To study the clinical and hormonal characteristics and the prevalence of different forms of mastopathy in women with thyroid gland pathology in the Bukhara region, 100 women aged 18–59 years with benign breast diseases…
The choice of anesthetic strategy in children undergoing craniotomy for brain tumors requires a comprehensive assessment not only of intracranial hypertension control, but also of systemic hemodynamics, tissue…
Zamonaviy tibbiyot jurnali / Journal of modern medicine — barcha maqolalar · 2026-yil arxivi
Настоящее исследование посвящено разработке алгоритма раннего выявления сенсоневральной тугоухости у детей с использованием методов полимеразной цепной реакции (ПЦР). Обследовано 235 детей с нарушениями слуха, из…
В статье представлены клинические аспекты и диагностические проблемы выявления сенсоневральной тугоухости у новорождённых с перинатальной патологией. Обследовано 115 новорождённых, из которых 35 перенесли асфиксию, а у…
Сенсоневральная тугоухость (СНТ) у детей остаётся одной из наиболее актуальных проблем современной оториноларингологии и медицинской генетики. Ранняя диагностика нарушений слуха играет ключевую роль в предупреждении…
Сенсоневральная тугоухость у новорождённых является одной из ведущих причин нарушения слухоречевого развития и ранней инвалидизации. Наиболее уязвимыми считаются дети, перенёсшие перинатальные осложнения, такие как…
Mazkur eksperimental tadqiqotda yuqori yog‘li ratsion va seftriaksonning lipid hamda uglevod almashinuviga alohida va birgalikdagi ta’siri 160 ta oq zotsiz erkak kalamushda o‘rganildi. Tajriba hayvonlari to‘rtta guruhga…
Мазкур тадқиқотда Тошкет вилоятидаги Ўрта Чирчиқ тумани 25-сонли, Бўка тумани 3-сонли ва 9-сонли давлат мактабгача таълим ташкилотларида 2025 йил ёз мавсумидаги таомномаларнинг озиқ-овқат маҳсулотлари билан…