From empirical to pathogenetic choice of antihypertensive therapy: the role of bioimpedancemetry

D.D. Olimjonov, U.B. Karimova

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

Background. The proportion of patients with arterial hypertension achieving target blood pressure remains low, largely due to the empirical nature of therapy selection that disregards the individual haemodynamic mechanism of blood pressure elevation. Aim. To assess the clinical efficacy and safety of pathogenetically guided antihypertensive therapy based on haemodynamic phenotyping by bioimpedancemetry compared with the standard empirical approach. Materials and methods. A prospective open-label randomized controlled trial enrolled 120 patients with grade I–II arterial hypertension, randomized 5:1 into the main group (n=100; bioimpedancemetry-guided therapy) and the control group (n=20; standard therapy). A reference group comprised 25 healthy individuals. Follow-up lasted 6 months. Results. Marked haemodynamic heterogeneity was revealed: vasoconstrictive phenotype — 40.8%, mixed — 25.0%, hyperdynamic — 18.3%, hypervolemic — 15.8%. The systolic blood pressure reduction in the main group was 28.9±7.6 versus 18.1±9.4 mmHg (p<0.01); target blood pressure was achieved by 84.0% versus 55.0% (p<0.01); normalization of the haemodynamic profile — 66.0% versus 35.0% (p=0.006). Adverse events were less frequent (9.0% versus 25.0%; p<0.01). Conclusion. Pathogenetically guided therapy based on bioimpedancemetry is superior to the empirical approach in efficacy and safety.

Maqola ma’lumotlari
MualliflarD.D. Olimjonov, U.B. Karimova
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-08-05
Jild14
Son3
Betlar526-531
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.006
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.006 · Maqolaning asl sahifasi · PDF

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Tibbiyot

Iqtibos keltirish

APAD.D. Olimjonov, & U.B. Karimova (2026). FROM EMPIRICAL TO PATHOGENETIC CHOICE OF ANTIHYPERTENSIVE THERAPY: THE ROLE OF BIOIMPEDANCEMETRY. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 526-531. https://doi.org/10.67519/nshr.ztj.2026.03.006
GOST (OAK)D.D. Olimjonov, U.B. Karimova FROM EMPIRICAL TO PATHOGENETIC CHOICE OF ANTIHYPERTENSIVE THERAPY: THE ROLE OF BIOIMPEDANCEMETRY // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 526-531. – DOI: 10.67519/nshr.ztj.2026.03.006.
MLAD.D. Olimjonov, and U.B. Karimova. “FROM EMPIRICAL TO PATHOGENETIC CHOICE OF ANTIHYPERTENSIVE THERAPY: THE ROLE OF BIOIMPEDANCEMETRY.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 526-531, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.006
ChicagoD.D. Olimjonov, and U.B. Karimova. “FROM EMPIRICAL TO PATHOGENETIC CHOICE OF ANTIHYPERTENSIVE THERAPY: THE ROLE OF BIOIMPEDANCEMETRY.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 526-531 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.006
HarvardD.D. Olimjonov, and U.B. Karimova (2026) ‘FROM EMPIRICAL TO PATHOGENETIC CHOICE OF ANTIHYPERTENSIVE THERAPY: THE ROLE OF BIOIMPEDANCEMETRY’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 526-531. https://doi.org/10.67519/nshr.ztj.2026.03.006
BibTeX
@article{ddolimjonov2026,
  title = {FROM EMPIRICAL TO PATHOGENETIC CHOICE OF ANTIHYPERTENSIVE THERAPY: THE ROLE OF BIOIMPEDANCEMETRY},
  author = {D.D. Olimjonov and U.B. Karimova},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {526-531},
  doi = {10.67519/nshr.ztj.2026.03.006},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.006}
}

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