Relevance. Quercetin has the properties of an inhibitor of a number of oxidase enzymes, a powerful antioxidant, a drug that helps neutralize nitric oxide in ischemic tissues and, accordingly, a pronounced membrane stabilizing effect. Purpose of the study is to substantiate the use of flavonoid (quercetin) in diabetic retinopathy (DR). Materials and methods. The study material was the blood serum of DM patients, the studies were conducted in vitro. 129 patients with DR were examined, divided into groups. The control consisted of 24 healthy donors in the appropriate age range. Results and conclusion. The revealed increase in the synthesis of proinflammatory cytokines IL‑1β and TNF-α by mononuclear leukocytes, as the severity of angiopathy increases in patients with DR, can be regarded as an important pathogenetic «component» of the progression of angiopathy. Hyperglycemia- and insulinependentleukocyte (lymphocyte)-the mediated mechanism of cytokine imbalance formation is an essential mechanism for the progression of DR. We have established that in DR there is a statistically significant effect of flavonoid (quercetin) on the functional activity of mononuclear cells, which allows us to recommend it for the treatment of DR.
| Mualliflar | Н В Иванова, Н А Ярошева, Л М Ярошева |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2024-06-19 |
| Jild | 8 |
| Son | 2 |
| Betlar | 55-58 |
| Til | ru |
| DOI | 10.57231/j.ao.2024.8.2.010 |
DOI: 10.57231/j.ao.2024.8.2.010 · Maqolaning asl sahifasi
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