Clinical and immunological aspects of forecasting reperfusion injuries of the myocardium during cardiac surgery

Umarov Bakhtiyor Yatgarovich, Siddikov Azizbek Murad-ugly

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

Myocardial reperfusion damage (MRD) remains one of the main causes of the complicated course of the early postoperative period in patients who have undergone cardiac surgery with artificial circulation (CA). Despite the use of modern cardioprotective strategies, the frequency of pronounced reperfusion disorders reaches 25-40%, which is accompanied by an increased risk of arrhythmias, a decrease in myocardial contractile function, the need for inotropic support, and an increase in the length of stay in the intensive care unit. The aim of the study is to identify clinical and immunological markers that allow predicting the severity of RPM. The study included 120 patients operated on with IC. Before and after surgical intervention, the levels of IL-6, TNF-α, CRP, HMGB1, Fas/FasL, troponin I, and CK-MB were determined dynamically. An increase in IL-6 > 35 pg/ml and TNF-α > 30 pg/ml 6-12 hours after surgery is associated with a high frequency of complications (AUC = 0.82 and 0.79, respectively). The combination of IL-6 > 35 pg/ml + Fas > 120 pg/ml showed the highest prognostic accuracy (sensitivity 84%, specificity 76%). The obtained data confirm the significance of immunological markers in addition to standard biochemical tests and allow us to propose an algorithm for early prediction of RPM.

Maqola ma’lumotlari
MualliflarUmarov Bakhtiyor Yatgarovich, Siddikov Azizbek Murad-ugly
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-04-14
Jild2
Son4/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

reperfusion, myocardium, cytokines, IL-6, TNF-α, Fas, artificial circulation, prognosis, immunology., реперфузия, миокард, цитокины, IL-6, TNF-α, Fas, искусственное кровообращение, прогнозирование, иммунология., реперфузия, миокард, цитокинлар, ИЛ-6, ТНФ-α, Фас, сунъий қон айланиши, прогнозлаш, иммунология.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUmarov Bakhtiyor Yatgarovich, & Siddikov Azizbek Murad-ugly (2026). CLINICAL AND IMMUNOLOGICAL ASPECTS OF FORECASTING REPERFUSION INJURIES OF THE MYOCARDIUM DURING CARDIAC SURGERY. Klinik fanlar yilnomasi, 2(4/2). https://tadqiqot.uz/index.php/spjacd/article/view/13434
GOST (OAK)Umarov Bakhtiyor Yatgarovich, Siddikov Azizbek Murad-ugly CLINICAL AND IMMUNOLOGICAL ASPECTS OF FORECASTING REPERFUSION INJURIES OF THE MYOCARDIUM DURING CARDIAC SURGERY // Klinik fanlar yilnomasi. – 2026. – T. 2, № 4/2.
MLAUmarov Bakhtiyor Yatgarovich, and Siddikov Azizbek Murad-ugly. “CLINICAL AND IMMUNOLOGICAL ASPECTS OF FORECASTING REPERFUSION INJURIES OF THE MYOCARDIUM DURING CARDIAC SURGERY.” Klinik fanlar yilnomasi, 2(4/2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/13434
ChicagoUmarov Bakhtiyor Yatgarovich, and Siddikov Azizbek Murad-ugly. “CLINICAL AND IMMUNOLOGICAL ASPECTS OF FORECASTING REPERFUSION INJURIES OF THE MYOCARDIUM DURING CARDIAC SURGERY.” Klinik fanlar yilnomasi, 2(4/2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/13434
HarvardUmarov Bakhtiyor Yatgarovich, and Siddikov Azizbek Murad-ugly (2026) ‘CLINICAL AND IMMUNOLOGICAL ASPECTS OF FORECASTING REPERFUSION INJURIES OF THE MYOCARDIUM DURING CARDIAC SURGERY’, Klinik fanlar yilnomasi, 2(4/2). https://tadqiqot.uz/index.php/spjacd/article/view/13434
BibTeX
@article{umarovbakhtiyoryatgarovich2026,
  title = {CLINICAL AND IMMUNOLOGICAL ASPECTS OF FORECASTING REPERFUSION INJURIES OF THE MYOCARDIUM DURING CARDIAC SURGERY},
  author = {Umarov Bakhtiyor Yatgarovich and Siddikov Azizbek Murad-ugly},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {2},
  number = {4/2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/13434}
}

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