Immunological mechanisms of myocardial remodeling in children after transcatheter closure of ventricular septal defect

Mullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, Yusupov Alisher Davletovich

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

A prospective study included 180 patients, of whom 103 had favorable remodeling and 77 had signs of adverse remodeling. We assessed the indicators of innate, adaptive, and humoral immunity, the levels of pro-inflammatory and pro-fibrotic cytokines (IL-6, IL-10, TNF-α, TGF-β1), markers of innate immunity (TLR4, HLA-DR, sCD14), immunoglobulins, and biomarkers of myocardial damage (NT-proBNP, troponin I). It has been shown that a complex immune response disorder precedes and accompanies the formation of AMR. An integral profile of immune risk has been established, including nine independent predictors. The developed prognostic IPREM scale demonstrates high diagnostic accuracy and can be implemented in clinical practice. The obtained data expand the understanding of cardio-immune interactions and allow for optimizing the observation strategy for children after interventional procedures.

Maqola ma’lumotlari
MualliflarMullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, Yusupov Alisher Davletovich
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-04-13
Jild2
Son4/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

VSD, transcatheter closure, myocardial remodeling, immune markers, cytokines, children, TLR4, TGF-β1, IPREM., ДМЖП, транскатетерное закрытие, ремоделирование миокарда, иммунные маркеры, цитокины, дети, TLR4, TGF-β1, IPREM., транскатетер ёпилиши, миокард ремоделланиши, иммун маркерлар, ситокинлар, болалар, ТЛР4, ТГФ-β1, ИПРЕМ.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, & Yusupov Alisher Davletovich (2026). IMMUNOLOGICAL MECHANISMS OF MYOCARDIAL REMODELING IN CHILDREN AFTER TRANSCATHETER CLOSURE OF VENTRICULAR SEPTAL DEFECT. Klinik fanlar yilnomasi, 2(4/2). https://tadqiqot.uz/index.php/spjacd/article/view/13416
GOST (OAK)Mullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, Yusupov Alisher Davletovich IMMUNOLOGICAL MECHANISMS OF MYOCARDIAL REMODELING IN CHILDREN AFTER TRANSCATHETER CLOSURE OF VENTRICULAR SEPTAL DEFECT // Klinik fanlar yilnomasi. – 2026. – T. 2, № 4/2.
MLAMullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, and Yusupov Alisher Davletovich. “IMMUNOLOGICAL MECHANISMS OF MYOCARDIAL REMODELING IN CHILDREN AFTER TRANSCATHETER CLOSURE OF VENTRICULAR SEPTAL DEFECT.” Klinik fanlar yilnomasi, 2(4/2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/13416
ChicagoMullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, and Yusupov Alisher Davletovich. “IMMUNOLOGICAL MECHANISMS OF MYOCARDIAL REMODELING IN CHILDREN AFTER TRANSCATHETER CLOSURE OF VENTRICULAR SEPTAL DEFECT.” Klinik fanlar yilnomasi, 2(4/2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/13416
HarvardMullabayeva Guzal Uchkunovna, Umarov Bakhtiyorjon Yatgarovich, and Yusupov Alisher Davletovich (2026) ‘IMMUNOLOGICAL MECHANISMS OF MYOCARDIAL REMODELING IN CHILDREN AFTER TRANSCATHETER CLOSURE OF VENTRICULAR SEPTAL DEFECT’, Klinik fanlar yilnomasi, 2(4/2). https://tadqiqot.uz/index.php/spjacd/article/view/13416
BibTeX
@article{mullabayevaguzaluchkunovna2026,
  title = {IMMUNOLOGICAL MECHANISMS OF MYOCARDIAL REMODELING IN CHILDREN AFTER TRANSCATHETER CLOSURE OF VENTRICULAR SEPTAL DEFECT},
  author = {Mullabayeva Guzal Uchkunovna and Umarov Bakhtiyorjon Yatgarovich and Yusupov Alisher Davletovich},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {2},
  number = {4/2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/13416}
}

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