Clinical and immunological characteristics and prognostic significance of immune markers in patients with breast cancer

Khodzhaeva Dilrukh Ilkhomovna, Umarov Bakhtiyorjon Yatgarovich

Klinik fanlar yilnomasi · 2026-yil

Annotatsiya

Breast cancer remains one of the leading causes of death among women and is characterized by high biological heterogeneity, which determines the differences in response to therapy. Despite the development of molecular genetic methods and the introduction of immunotherapy, the problem of early prediction of treatment outcomes and the risk of recurrence remains unresolved. The work presents the results of a comprehensive clinical and immunological study of 290 patients with breast cancer who underwent treatment at oncology centers in Uzbekistan in 2020-2024. Lymphocyte subpopulations, cytokine profile (IL-2, IL-6, IL-10, TNF-α, IFN-γ), PD-1/PD-L1 expression, and their relationship with clinical characteristics and therapy responses were studied. It has been shown that an increase in IL-6 and TNF-α, a decrease in CD4/CD8, and the expression of PD-L1 are associated with more aggressive subtypes of the tumor and a high risk of progression. Prognostic indices have been developed that integrate clinical and immunological parameters, allowing for the assessment of the likelihood of recurrence and individual response to treatment. The obtained data form a scientific basis for personalizing breast cancer therapy and implementing immunological criteria in clinical practice.

Maqola ma’lumotlari
MualliflarKhodzhaeva Dilrukh Ilkhomovna, Umarov Bakhtiyorjon Yatgarovich
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2026-04-14
Jild2
Son4/2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

breast cancer, cytokines, immune checkpoints, prognosis, PD-1, PD-L1, IL-6, TNF-α, TILs., рак молочной железы, цитокины, иммунные контрольные точки, прогнозирование, PD-1, PD-L1, IL-6, TNF-α, TILs., сут бези саратони, ситокинлар, иммун назорат нуқталари, башоратлаш, PD-1, PD-L1, IL-6, ТНФ-α, ТИЛс.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKhodzhaeva Dilrukh Ilkhomovna, & Umarov Bakhtiyorjon Yatgarovich (2026). CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF IMMUNE MARKERS IN PATIENTS WITH BREAST CANCER. Klinik fanlar yilnomasi, 2(4/2). https://tadqiqot.uz/index.php/spjacd/article/view/13436
GOST (OAK)Khodzhaeva Dilrukh Ilkhomovna, Umarov Bakhtiyorjon Yatgarovich CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF IMMUNE MARKERS IN PATIENTS WITH BREAST CANCER // Klinik fanlar yilnomasi. – 2026. – T. 2, № 4/2.
MLAKhodzhaeva Dilrukh Ilkhomovna, and Umarov Bakhtiyorjon Yatgarovich. “CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF IMMUNE MARKERS IN PATIENTS WITH BREAST CANCER.” Klinik fanlar yilnomasi, 2(4/2), 2026. https://tadqiqot.uz/index.php/spjacd/article/view/13436
ChicagoKhodzhaeva Dilrukh Ilkhomovna, and Umarov Bakhtiyorjon Yatgarovich. “CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF IMMUNE MARKERS IN PATIENTS WITH BREAST CANCER.” Klinik fanlar yilnomasi, 2(4/2) (2026). https://tadqiqot.uz/index.php/spjacd/article/view/13436
HarvardKhodzhaeva Dilrukh Ilkhomovna, and Umarov Bakhtiyorjon Yatgarovich (2026) ‘CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF IMMUNE MARKERS IN PATIENTS WITH BREAST CANCER’, Klinik fanlar yilnomasi, 2(4/2). https://tadqiqot.uz/index.php/spjacd/article/view/13436
BibTeX
@article{khodzhaevadilrukhilkhomovna2026,
  title = {CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE OF IMMUNE MARKERS IN PATIENTS WITH BREAST CANCER},
  author = {Khodzhaeva Dilrukh Ilkhomovna and Umarov Bakhtiyorjon Yatgarovich},
  journal = {Klinik fanlar yilnomasi},
  year = {2026},
  volume = {2},
  number = {4/2},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/13436}
}

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