Numerous studies report linkage between chronic kidney disease (CKD) and cerebrovascular disease. This association has been particularly strong for cerebral small vessel disease. Significant findings have emerged from studies ranging from case reports, small case series, and larger cohort investigations. The latter show a relationship between declining renal function, microvascular disease, and cognitive impairment. One troubling aspect has been the relative paucity of mechanistic investigations addressing the CKD-cerebrovascular disease linkage. Nevertheless, mechanistic observations have begun to emerge, showing cerebral microhemorrhage development in animal models of CKD independent of hypertension, an important co-morbidity in clinical studies. Initial cell culture studies show endothelial monolayer disruption by CKD serum, suggesting blood-brain barrier injury.
| Mualliflar | Хайдарова Дильдора Кадировна, Кудратова Шаходат Рамазоновна |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2024-09-26 |
| Jild | 5 |
| Son | 4 |
| Til | Ingliz |
почка; микрососудистые заболевания;микрокровотечения; модели животных, kidney; microvascular disease; microbleeds; animal models, : buyrak; mikrotomir kasalliklari; mikroqon ketish; hayvonlar modellari
Medical genetics, being a relatively young science, remains the most urgent and demanding problem to this day. The largest percentage of this group is hereditary neuromuscular diseases, which are characterized by early…
The results of treatment of 183 elderly and senile patients and 65 young and middle-aged patients with traumatic intracranial hemorrhages were analyzed. The course of subdural hydroma after decompressive craniectomy and…
This article presents our own results of assessing the level of speech development in preschool children with functional and organic changes in the brain. The data of the examination to determine the severity of speech…
The article provides data on the study of the effect of chemo-induced polyneuropathy (HIPN) on the daily activity and quality of life of patients with ovarian cancer, as well as evaluating the effectiveness of the use…
This article presentstheresultsof astudyof themanifestationsofneurasthenia,which issignificantly predominantinmen with infertility, whilethemost common complaintsof aneurosthenic nature were irritability, general…
In recent years, the number of patients with temporomandibular joint dysfunction pain syndrome has increased, which occurs in the majority of the adult population of developed countries: from 21.1 to 99%. This disease…
One of the most common causes of trigeminal neuralgia is vascular compression of the nerve due to abnormal vessel location or vascular changes, most often atherosclerosis. In 80-90% of cases, trigeminal neuralgia is…
Taransient ischemic attacks are considered one of the most attention - intensive pathologies among neurological diseases in the world, including acute disorders of the cerebral circulation. Transient ischemic attacks…
Aim. To study the role of nanotropil in the treatment of chronic vertebrobasilar insufficiency. Materials and methods. In the neurological department of the Samarkand branch of the Russian Research Center for Emergency…
A total of 46 patients with cognitive disorders (their age was 65-85 years old) participated in our observation in two identical groups: 23 patients in the main group and 23 patients in the second group. We used the…