Polymorphism PRO12ALA of the PPARG-2 gene (rs1801282) in children with obesity

Garifullina, Lilia, Rustamov, Uktam, Гарифулина, Лиля, Рустамов, Уктам, Garifulina, Lilya, Rustamov, O‘ktam

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Resume: This article presents data from a study of the Pro12Ala polymorphism of the PPARG-2 gene in obese children. The study results are recommended for widespread implementation in the practice of pediatric hospital physicians. The aim of the work: to study the frequency of the Pro12Ala polymorphism of the PPARG 2 gene in children with different types of obesity. Materials and methods: a comparative characteristic of the study of the frequency of carriage of the Pro 12 Ala polymorphism of the PPARG-2 gene in 211 children with obesity and 104 children with normal body weight was carried out. The method of molecular genetic examination was used. Results: It was revealed that the Pro 12 Pro genotype of the Pro 12 Ala polymorphism of the PPARG-2 isoform gene of the peroxisome activator gene was directly associated with the formation of obesity in children and adolescents, namely abdominal obesity. The predisposing genotype in children with AO was Pro12 Pro, and in children with abdominal obesity without metabolic disorders, the frequency of the minor allele 12Ala was statistically higher compared to children with manifestations of MS, which allows us to classify this allele as protective for the development of metabolic disorders.

Maqola ma’lumotlari
MualliflarGarifullina, Lilia, Rustamov, Uktam, Гарифулина, Лиля, Рустамов, Уктам, Garifulina, Lilya, Rustamov, O‘ktam
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-10-25
Jild4
Son5
Betlar31-35
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-5-31-35
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-5-31-35 · Maqolaning asl sahifasi

Kalit so‘zlar

PPARG-2 gene polymorphism, abdominal obesity, uniform obesity, children, полиморфизм гена PPARG-2, абдоминальное ожирение, равномерное ожирение, дети, PPARG-2 genining polimorfizmi, abdominal semizlik, teng taqsimlangan semizlik, bolalar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAGarifullina, Lilia, Rustamov, Uktam, Гарифулина, Лиля, Рустамов, Уктам, Garifulina, Lilya, & Rustamov, O‘ktam (2025). POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 31-35. https://doi.org/10.56121/2181-3612-2025-5-31-35
GOST (OAK)Garifullina, Lilia va b. POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 5. – P. 31-35. – DOI: 10.56121/2181-3612-2025-5-31-35.
MLAGarifullina, Lilia, Rustamov, Uktam, Гарифулина, Лиля, Рустамов, Уктам, Garifulina, Lilya, and Rustamov, O‘ktam. “POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 31-35, 2025. https://doi.org/10.56121/2181-3612-2025-5-31-35
ChicagoGarifullina, Lilia, Rustamov, Uktam, Гарифулина, Лиля, Рустамов, Уктам, Garifulina, Lilya, and Rustamov, O‘ktam. “POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 31-35 (2025). https://doi.org/10.56121/2181-3612-2025-5-31-35
HarvardGarifullina, Lilia, Rustamov, Uktam, Гарифулина, Лиля, Рустамов, Уктам, Garifulina, Lilya, and Rustamov, O‘ktam (2025) ‘POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 31-35. https://doi.org/10.56121/2181-3612-2025-5-31-35
BibTeX
@article{garifullinalilia2025,
  title = {POLYMORPHISM PRO12ALA OF THE PPARG-2 GENE (rs1801282) IN CHILDREN WITH OBESITY},
  author = {Garifullina, Lilia and Rustamov, Uktam and Гарифулина, Лиля and Рустамов, Уктам and Garifulina, Lilya and Rustamov, O‘ktam},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {5},
  pages = {31-35},
  doi = {10.56121/2181-3612-2025-5-31-35},
  url = {https://doi.org/10.56121/2181-3612-2025-5-31-35}
}

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