The influence of motor fluctuations on psychoemotional status and quality of life in parkinson's disease

Naimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod, Наимов, Олим, Матмуродов, Рустамбек, Муминов, Бекзод, Naimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Relevance. Parkinson's disease is a neurodegenerative disease of the nervous system and one of the most topical problems in neurology. Motor fluctuations are a common complication of long-term levodopa treatment in patients with Parkinson's disease. Рurpose of the study. To study the effect of motor fluctuations on the psychoemotional state and quality of life of patients with Parkinson's disease. Materials and methods of the study. The study included 120 patients with various clinical forms of Parkinson's disease. To compare the parameters during the study, the patients were divided into 2 groups: patients with motor fluctuations (55 people) and patients without motor fluctuations (65 people). All patients underwent clinical neurological and neuropsychological examinations. Research results. In the group with motor fluctuations, the comorbid form of affective disorders, that is, depression + anxiety, was significantly higher: in the group with fluctuations - 54.5% (30/55 patients), in the group without fluctuations - 24.6% (16/65 patients). When assessing the significance of this difference using the χ² test, the obtained value was p<0.01. Thus, it can be noted that motor fluctuations are strongly associated with more severe and comorbid forms of mental disorders (depression and anxiety). The results obtained based on the PDQ-39 scale domains show that psychoemotional disorders have varying degrees of negative impact on virtually all areas of life. Conclusion. When assessing quality of life using the PDQ-39 questionnaire, patients with anxiety and depression showed a significant decrease in indicators such as mobility, daily activities, emotional state, cognitive function, and social support. The greatest negative impact was observed in the group with comorbid depression and anxiety.

Maqola ma’lumotlari
MualliflarNaimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod, Наимов, Олим, Матмуродов, Рустамбек, Муминов, Бекзод, Naimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-10-25
Jild4
Son5
Betlar20-26
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-5-20-26
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-5-20-26 · Maqolaning asl sahifasi

Kalit so‘zlar

Parkinson's disease, fluctuation, psychoemotional status, Болезнь Паркинсона, флуктуaция, психоэмоциональный статус, Parkinson kasalligi, fluktuatsiya, psixoemotsional holat

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APANaimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod, Наимов, Олим, Матмуродов, Рустамбек, Муминов, Бекзод, Naimov, Olim, Matmurodov, Rustambek, & Muminov, Bekzod (2025). THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 20-26. https://doi.org/10.56121/2181-3612-2025-5-20-26
GOST (OAK)Naimov, Olim va b. THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 5. – P. 20-26. – DOI: 10.56121/2181-3612-2025-5-20-26.
MLANaimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod, Наимов, Олим, Матмуродов, Рустамбек, Муминов, Бекзод, Naimov, Olim, Matmurodov, Rustambek, and Muminov, Bekzod. “THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 20-26, 2025. https://doi.org/10.56121/2181-3612-2025-5-20-26
ChicagoNaimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod, Наимов, Олим, Матмуродов, Рустамбек, Муминов, Бекзод, Naimov, Olim, Matmurodov, Rustambek, and Muminov, Bekzod. “THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 20-26 (2025). https://doi.org/10.56121/2181-3612-2025-5-20-26
HarvardNaimov, Olim, Matmurodov, Rustambek, Muminov, Bekzod, Наимов, Олим, Матмуродов, Рустамбек, Муминов, Бекзод, Naimov, Olim, Matmurodov, Rustambek, and Muminov, Bekzod (2025) ‘THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(5), 20-26. https://doi.org/10.56121/2181-3612-2025-5-20-26
BibTeX
@article{naimovolim2025,
  title = {THE INFLUENCE OF MOTOR FLUCTUATIONS ON PSYCHOEMOTIONAL STATUS AND QUALITY OF LIFE IN PARKINSON'S DISEASE},
  author = {Naimov, Olim and Matmurodov, Rustambek and Muminov, Bekzod and Наимов, Олим and Матмуродов, Рустамбек and Муминов, Бекзод and Naimov, Olim and Matmurodov, Rustambek and Muminov, Bekzod},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {5},
  pages = {20-26},
  doi = {10.56121/2181-3612-2025-5-20-26},
  url = {https://doi.org/10.56121/2181-3612-2025-5-20-26}
}

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