The purpose of the study is to review the literature on the pathogenesis of diabetic nephropathy. Material and research methods. In order to analyze the literature, a keyword search was performed in Pubmed, Google Scholar, Scopus and other sites over the past 5-10 years. Research results. The pathogenesis of DN is very complex and is still not fully understood, which leads to poor therapeutic results. Standard therapy with strict control of blood sugar and blood pressure has been shown to fail to stop the progression of DN to terminal stage of chronic kidney disease and the mortality associated with DN. Improving understanding and studying the pathogenetic mechanisms of DN is important for the development of new treatment strategies for DN. There are multiple pathways and mediators involved in the development and progression of DN, including oxidative stress, angiotensin II (Ang-II), and inflammatory processes, which have recently been suggested to play important roles. Conclusions. A review of the literature showed that there is an urgent need to improve the understanding of the mechanism of DN and then develop new and effective therapeutic approaches to slow the progression of DN.
| Mualliflar | Холиков А.Ю, Урманова Ю.М, Бердыкулова Д.М, Худойбердиева Д.Д |
|---|---|
| Jurnal | Марказий Осиё эндокринологик журнали |
| Nashr sanasi | 2024-07-04 |
| Jild | 4 |
| Son | 1 |
| Til | Rus |
сахарный диабет 2 типа, хроническая болезнь почек, биохимические показатели, type 2 diabetes mellitus, chronic kidney disease, biochemical parameters, 2 тур қандли диабет, сурункали буйрак касаллиги, биокимёвий кўрсаткичлар
Obesity is a well-established risk factor for the development of insulin resistance and type 2 diabetes, and body fat distribution is important for this metabolic risk. Materials and methods: In this cross-sectional…
Thе аrticlе discussеs thе fеаturеs of thyroid function in childrеn аnd аdolеscеnts with nodulаr аnd multinodulаr goitеr. For this purposе, 24 childrеn with nodulаr goitеr/multinodulаr goitеr wеrе studiеd, thе аvеrаgе…
Current publication demonstrates iodine deficiency level, in accordance with WHO recommendations with sentinel method, in Uzbekistan. Consumption of adequately iodized salt (15,0-55 ppm of potassium iodate) has…
Hypogonadism is characterized by a decrease in the quantity of testosterone, a steroid hormone, in men, along with the manifestation of hypogonadism symptoms. Currently, among men diagnosed with type 2 diabetes…
Immunohistochemistry is a valuable modern, but currently little-studied method for diagnosing carcinogenesis of thyroid nodules. The article discusses such immunohistochemical markers used in the diagnosis and…
Primary adrenal insufficiency, or Addison's disease, is a polyetiological disease, the most common of which is autoimmune adrenalitis. Autoimmune adrenalitis results from destruction of the adrenal cortex, resulting in…
For patients with diabetes, one of the main therapeutic goals is to achieve target glycemic levels. In the presence of NAFLD, the attending physician is faced with some restrictions when choosing glucose-lowering…
Despite the ongoing activities, the prevalence of iodine deficiency diseases (IDD) remains high in the Republic of Uzbekistan. The prevalence of endemic goiter decreased from 70% in 1998 to 31% in 2016 among the…
The World Obesity Federation Predicts a global prevalence of obesity by 2030 of more than 18% among men and 21% among women. Material and methods: data were analyzed The data of RSNPMC of Endocrinology named after Acad…
Cystatin-C is an endogenous protein of low molecular weight, produced in all nucleated cells, and excreted from the body only through the kidneys. It does not accumulate in the blood vessels, tissues and proximal…