Unresolved issues of medication related osteonecrosis of the jaw in bisphosphonate treatment of bone metastases from prostate cancer

MINNULIN Irkin Rashidovich, RAKHIMBERDIEV Rustam Abdunasirovich, MIRZAQULOV Buned G'aybullayevich, TURSUNOV Sherali Sirozhiddinovich, URAZOV Nuriddin Elmurotovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

The article focuses on unresolved issues of medication‑related osteonecrosis of the jaw (MRONJ) in patients with bone metastases from prostate cancer receiving bisphosphonate therapy. Current concepts of the role of antiresorptive treatment in the management of skeletal metastases are summarized, and key stages in the pathogenesis of MRONJ under prolonged bisphosphonate exposure combined with androgen deprivation and systemic anticancer therapy are discussed. Particular attention is paid to risk factors specific to the prostate cancer population, including advanced age, multimorbidity, duration and intensity of antiresorptive therapy, poor oral health, and traumatic dental procedures. Diagnostic challenges are analyzed, such as early detection and differential diagnosis of jaw lesions in oncologic patients. Existing conservative and surgical treatment strategies for MRONJ are reviewed, with emphasis on controversial issues regarding the extent of surgery and the management of antiresorptive therapy once osteonecrosis has developed. The concluding section outlines the major unresolved problems and highlights future research directions, including the need for individualized risk prediction models and prevention algorithms tailored to patients with metastatic prostate cancer.

Maqola ma’lumotlari
MualliflarMINNULIN Irkin Rashidovich, RAKHIMBERDIEV Rustam Abdunasirovich, MIRZAQULOV Buned G'aybullayevich, TURSUNOV Sherali Sirozhiddinovich, URAZOV Nuriddin Elmurotovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-06
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

рак предстательной железы, костные метастазы, бисфосфонаты, остеонекроз челюсти, факторы риска, prostate cancer, bone metastases, bisphosphonates, osteonecrosis of the jaw, risk factors, prostata bezi raki, suyak metastazlari, bisfosfonatlar, jag‘ osteonekrozi, xavf omillari

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Iqtibos keltirish

APAMINNULIN Irkin Rashidovich, RAKHIMBERDIEV Rustam Abdunasirovich, MIRZAQULOV Buned G'aybullayevich, TURSUNOV Sherali Sirozhiddinovich, & URAZOV Nuriddin Elmurotovich (2026). UNRESOLVED ISSUES OF MEDICATION RELATED OSTEONECROSIS OF THE JAW IN BISPHOSPHONATE TREATMENT OF BONE METASTASES FROM PROSTATE CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13722
GOST (OAK)MINNULIN Irkin Rashidovich va b. UNRESOLVED ISSUES OF MEDICATION RELATED OSTEONECROSIS OF THE JAW IN BISPHOSPHONATE TREATMENT OF BONE METASTASES FROM PROSTATE CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLAMINNULIN Irkin Rashidovich, RAKHIMBERDIEV Rustam Abdunasirovich, MIRZAQULOV Buned G'aybullayevich, TURSUNOV Sherali Sirozhiddinovich, and URAZOV Nuriddin Elmurotovich. “UNRESOLVED ISSUES OF MEDICATION RELATED OSTEONECROSIS OF THE JAW IN BISPHOSPHONATE TREATMENT OF BONE METASTASES FROM PROSTATE CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13722
ChicagoMINNULIN Irkin Rashidovich, RAKHIMBERDIEV Rustam Abdunasirovich, MIRZAQULOV Buned G'aybullayevich, TURSUNOV Sherali Sirozhiddinovich, and URAZOV Nuriddin Elmurotovich. “UNRESOLVED ISSUES OF MEDICATION RELATED OSTEONECROSIS OF THE JAW IN BISPHOSPHONATE TREATMENT OF BONE METASTASES FROM PROSTATE CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13722
HarvardMINNULIN Irkin Rashidovich, RAKHIMBERDIEV Rustam Abdunasirovich, MIRZAQULOV Buned G'aybullayevich, TURSUNOV Sherali Sirozhiddinovich, and URAZOV Nuriddin Elmurotovich (2026) ‘UNRESOLVED ISSUES OF MEDICATION RELATED OSTEONECROSIS OF THE JAW IN BISPHOSPHONATE TREATMENT OF BONE METASTASES FROM PROSTATE CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13722
BibTeX
@article{minnulinirkinrashidovich2026,
  title = {UNRESOLVED ISSUES OF MEDICATION RELATED OSTEONECROSIS OF THE JAW IN BISPHOSPHONATE TREATMENT OF BONE METASTASES FROM PROSTATE CANCER},
  author = {MINNULIN Irkin Rashidovich and RAKHIMBERDIEV Rustam Abdunasirovich and MIRZAQULOV Buned G'aybullayevich and TURSUNOV Sherali Sirozhiddinovich and URAZOV Nuriddin Elmurotovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13722}
}

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