Precision optimization of radiotherapy planning for head and neck tumors based on the integration of multiparametric imaging data

KARIMOVA Nargiza Sunnatillayevna, XASANBOYEV Saidjon Gayratjon o’g’li

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

The aim of the study was to evaluate the clinical effectiveness and safety of multimodal radiotherapy planning for head and neck tumors through the integration of CT, MRI, and PET/CT imaging data. A prospective-retrospective comparative analysis included 22 patients treated with radical IMRT/VMAT (66–70 Gy). Two imaging protocols were compared: CT + MRI (n=15) and CT + MRI + PET/CT (n=7). The integration of PET/CT reduced the systematic error (Σ) from 3.2 to 1.8 mm and the random error (σ) from 2.1 to 1.2 mm, resulting in a 43% reduction of the calculated CTV–PTV margin (from 9.3 to 5.4 mm). The high-dose volume (70 Gy) decreased by 28% (p<0.05), with significant dose reduction to the brainstem and spinal cord. No increase in severe radiation toxicity was observed. A significant correlation was found between the PTV 66–70 Gy volume and dysphagia (r=0.42; p<0.05), and a threshold relationship was identified between xerostomia and parotid mean dose >26 Gy. Multimodal imaging-based planning with mathematically justified margin individualization enhances precision in radiotherapy and reduces toxicity without compromising oncological control.

Maqola ma’lumotlari
MualliflarKARIMOVA Nargiza Sunnatillayevna, XASANBOYEV Saidjon Gayratjon o’g’li
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-05-06
Jild11
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

опухоли головы и шеи, IMRT, VMAT, ПЭТ/КТ, делинеация, CTV-PTV маржин, геометрическая неопределённость, лучевая токсичность, прецизионная радиотерапия, head and neck tumors, IMRT, VMAT, PET/CT, target delineation, CTV–PTV margin, geometric uncertainty, radiation toxicity, precision radiotherapy, bosh va bo‘yin o‘smalari, IMRT, VMAT, PET/KT, konturlash, CTV–PTV marjin, geometrik noaniqlik, nur toksikligi, precizion radioterapiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKARIMOVA Nargiza Sunnatillayevna, & XASANBOYEV Saidjon Gayratjon o’g’li (2026). PRECISION OPTIMIZATION OF RADIOTHERAPY PLANNING FOR HEAD AND NECK TUMORS BASED ON THE INTEGRATION OF MULTIPARAMETRIC IMAGING DATA. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13720
GOST (OAK)KARIMOVA Nargiza Sunnatillayevna, XASANBOYEV Saidjon Gayratjon o’g’li PRECISION OPTIMIZATION OF RADIOTHERAPY PLANNING FOR HEAD AND NECK TUMORS BASED ON THE INTEGRATION OF MULTIPARAMETRIC IMAGING DATA // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 2.
MLAKARIMOVA Nargiza Sunnatillayevna, and XASANBOYEV Saidjon Gayratjon o’g’li. “PRECISION OPTIMIZATION OF RADIOTHERAPY PLANNING FOR HEAD AND NECK TUMORS BASED ON THE INTEGRATION OF MULTIPARAMETRIC IMAGING DATA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13720
ChicagoKARIMOVA Nargiza Sunnatillayevna, and XASANBOYEV Saidjon Gayratjon o’g’li. “PRECISION OPTIMIZATION OF RADIOTHERAPY PLANNING FOR HEAD AND NECK TUMORS BASED ON THE INTEGRATION OF MULTIPARAMETRIC IMAGING DATA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13720
HarvardKARIMOVA Nargiza Sunnatillayevna, and XASANBOYEV Saidjon Gayratjon o’g’li (2026) ‘PRECISION OPTIMIZATION OF RADIOTHERAPY PLANNING FOR HEAD AND NECK TUMORS BASED ON THE INTEGRATION OF MULTIPARAMETRIC IMAGING DATA’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(2). https://tadqiqot.uz/index.php/biomedicine/article/view/13720
BibTeX
@article{karimovanargizasunnatillayevna2026,
  title = {PRECISION OPTIMIZATION OF RADIOTHERAPY PLANNING FOR HEAD AND NECK TUMORS BASED ON THE INTEGRATION OF MULTIPARAMETRIC IMAGING DATA},
  author = {KARIMOVA Nargiza Sunnatillayevna and XASANBOYEV Saidjon Gayratjon o’g’li},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13720}
}

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