The aim of the study was to evaluate the clinical effectiveness and safety of multimodal radiotherapy planning for head and neck tumors through the integration of CT, MRI, and PET/CT imaging data. A prospective-retrospective comparative analysis included 22 patients treated with radical IMRT/VMAT (66–70 Gy). Two imaging protocols were compared: CT + MRI (n=15) and CT + MRI + PET/CT (n=7). The integration of PET/CT reduced the systematic error (Σ) from 3.2 to 1.8 mm and the random error (σ) from 2.1 to 1.2 mm, resulting in a 43% reduction of the calculated CTV–PTV margin (from 9.3 to 5.4 mm). The high-dose volume (70 Gy) decreased by 28% (p<0.05), with significant dose reduction to the brainstem and spinal cord. No increase in severe radiation toxicity was observed. A significant correlation was found between the PTV 66–70 Gy volume and dysphagia (r=0.42; p<0.05), and a threshold relationship was identified between xerostomia and parotid mean dose >26 Gy. Multimodal imaging-based planning with mathematically justified margin individualization enhances precision in radiotherapy and reduces toxicity without compromising oncological control.
| Mualliflar | KARIMOVA Nargiza Sunnatillayevna, XASANBOYEV Saidjon Gayratjon o’g’li |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-05-06 |
| Jild | 11 |
| Son | 2 |
| Til | Rus |
опухоли головы и шеи, IMRT, VMAT, ПЭТ/КТ, делинеация, CTV-PTV маржин, геометрическая неопределённость, лучевая токсичность, прецизионная радиотерапия, head and neck tumors, IMRT, VMAT, PET/CT, target delineation, CTV–PTV margin, geometric uncertainty, radiation toxicity, precision radiotherapy, bosh va bo‘yin o‘smalari, IMRT, VMAT, PET/KT, konturlash, CTV–PTV marjin, geometrik noaniqlik, nur toksikligi, precizion radioterapiya
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