Myosteatosis, defined as fatty infiltration of skeletal muscle, is an important component of body composition disorders in oncology. In metastatic gynecologic cancers, this condition is frequently underestimated when relying on conventional anthropometric measures, despite its significant impact on treatment tolerance and prognosis. This review summarizes current evidence on the pathophysiological mechanisms of myosteatosis, its association with chemotherapy-related toxicity, and its influence on overall and progression-free survival. Computed tomography–derived muscle density is shown to be an independent prognostic factor of adverse oncologic outcomes, particularly in patients with preserved or increased body mass index. The integration of myosteatosis assessment into multifactorial risk stratification models may improve personalized management strategies for patients with metastatic gynecologic malignancies.
| Mualliflar | SHAKHANOVA Shakhnoza Shavkatovna, KHOSHIMOV Bakhodir Bakhromovich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-05-06 |
| Jild | 11 |
| Son | 2 |
| Til | Rus |
миостеатоз, онкогинекологический рак, метастазы, токсичность химиотерапии, выживаемость, компьютерная томография, myosteatosis, gynecologic cancer, metastasis, chemotherapy toxicity, survival, computed tomography, miosteatoz, onkoginekologik rak, metastazlar, kimyoterapiya toksikligi, omon qolish, kompyuter tomografiya
This narrative review highlights the contemporary importance of a population-based approach to cervical cancer (CC). We summarize global and regional epidemiologic patterns of CC, the etiologic role of high-risk human…
Androgen deprivation therapy is a widely used treatment for metastatic prostate cancer. Androgen deprivation therapy can be administered medically or surgically and aims to suppress androgen production or block its…
Breast cancer is one of the most pressing issues in oncology. This is evidenced by the fact that breast cancer incidence rates are not among the best in the world, indicating the scale of this problem. This article…
Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and renal biopsy remains the gold standard for diagnosis and provides valuable information about disease severity and prognosis…
The aim of the study was to evaluate the clinical effectiveness and safety of multimodal radiotherapy planning for head and neck tumors through the integration of CT, MRI, and PET/CT imaging data. A…
The article presents a comprehensive analysis of a retrospective, diagnostic study of bronchiectasis in the population of the Samarkand region. The inclusion and exclusion criteria of patients were carefully studied…
Positron emission tomography (PET) is one of the modern, highly informative radionuclide tomographic methods for examining internal human organs. PET enables comprehensive assessment of tumor spread, allows measurement…
Based on the results of a clinical and instrumental examination and an analysis of case histories, the authors evaluate the problems of allergic rhinitis. A study was conducted on 44 patients aged 18 to 60 years…
The article focuses on unresolved issues of medication‑related osteonecrosis of the jaw (MRONJ) in patients with bone metastases from prostate cancer receiving bisphosphonate therapy. Current concepts of the role of…
Based on the results of practical observation of patients with congenital cholesteatoma, the authors point to a unique course of the disease and complications. The results of surgical treatment of two patients, aged 26…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar