From today's perspective, there are no gold standards for early detection of LTBI and differential diagnosis between latent and active tuberculosis infection in a child. Purpose of the study: to study the structure of somatic pathology and features of the epidemiological history during the development of LTBI and its progression in children. Materials and methods: A retrospective-prospective cohort study was conducted in accordance with the international STROBE standard. 60 children were selected and divided into three groups: Group 1 included 40 children with latent tuberculosis infection, Group 2 included 20 children with active tuberculosis. Group 1 is divided into: subgroup I, consisting of 20 children in whom the progression of LTBI to active tuberculosis was established and subgroup II, consisting of 20 children in whom progression of LTBI to active tuberculosis did not occur. Results and discussion. The decisive social risk factors were the child’s residence in a low-income (RR 5,000), large (RR 4,667), or single-parent family (RR 3,200), unsatisfactory living conditions for the child and his family (RR 4,857), and the father’s lack of permanent employment ( RR 3.467), secondary or secondary specialized level of education among parents (RR 3.000), maternal unemployment (RR 2.308), alcoholism, smoking abuse and drug addiction of parents (RR 2.000), and in our study the social factor of “disorganization” of the child was often present (RR 2,000). Considering somatic diseases that can act as risk factors for the development of an active tuberculosis process, we came to the following results: helminthic infestation (RR 3,000), iron deficiency anemia (RR 1,900), endocrinological pathology and metabolic disorders (RR 1,200), myopia (RR 1,429), gastritis and colitis (RR 2.286), rheumatism and osteomyelitis (RR 2.000), pyelonephritis (RR 1.333), kidney hydronephrosis (RR 3.000). It should be noted that the pathological conditions listed above also acted as predisposing factors to latent tuberculosis infection. However, in this group, we additionally established the significance of such a factor as respiratory pathology (bronchial asthma, allergic rhinitis) (RR 0.500). Conclusions. In the Republic of Uzbekistan, it is relevant to continue research work in this direction to assess the prognostic significance of previously established ones, as well as to discover new, modern factors, in order to improve the tactics of managing children with latent tuberculosis infection and prevent its progression into an active process.
| Mualliflar | ADJABLAYEVA Dinara Namazovna, PARPIYEVA Nargiza Nusratovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2024-12-25 |
| Jild | 9 |
| Son | 5 |
| Til | Rus |
латентная туберкулезная инфекция, факторы риска, активный туберкулез, дети, очаг туберкулезной инфекции, latent tuberculosis infection, risk factors, active tuberculosis, children, focus of tuberculosis infection, latent sil infektsiyasi, xavf omillari, faol sil, bolalar, sil infektsiyasining o'chog'i
The review touches upon modern information on cystic kidney diseases within the framework of the Bosniak M.A. classification, which covers all the various forms, from simple cysts to malignant ones. Literature data are…
In this review of the literature, the etio-patho-morphogenesis of the SARS-CoV-2 virus-caused COVID-19 disease - the acute stage of the disease and the manifestation of its post-disease syndromes, their…
A review of modern scientific literature on the diagnosis and treatment of urinary origin in intraperitoneal injuries of the bladder provides information on the state of emergency and urgent knowledge and assistance…
The work studied in vitro changes in the digestibility of starch when interacting with fats in the composition of starch-fat substrates. As a result of the study, it was found that with increasing time of the joint…
The work studied in vitro changes in starch digestibility when interacting with sunflower oil hydrolyzate as part of starch-fat substrates. As a result of the study, it was found that with increasing time of the joint…
In connection with the above, the purpose of this study was to study the risk factors leading to the development of massive obstetric hemorrhage. An analysis of 302000 birth histories in the Samarkand region for…
More and more surgeries will be replaced by endoscopic surgeries, which will allow patients to receive high-quality care, but without unnecessary consequences such as postoperative pain, long recovery, and large scars…
The indications, contraindications and recurrence rate in the application of radiofrequency ablation (RFA) of myomatous nodes in patients with uterine myoma have been studied, which allows to select patients for this…
Infertility is often caused by congenital anomalies of sexual development and is associated with an unfavorable reproductive prognosis. In recent years, the development of assisted reproductive technologies has…
The article presents data on the participation of "epithelial-mesenchymal transitions" in the pathogenetic mechanism of adhesion process development in women who have undergone gynecological surgeries. The pathogenetic…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar