Non-alcoholic fatty liver disease (NAFLD), as one of the factors of metabolic syndrome (MS), is currently the most common liver disease worldwide. Currently, no specific drug therapy for this condition has been developed; its treatment is based on the treatment of the main risk factors. The initial accumulation of triglycerides in the liver parenchyma, in the presence of inflammatory processes, mitochondrial dysfunction, lipotoxicity, glucose toxicity and oxidative stress, can develop into non-alcoholic steatohepatitis (NASH). The primary goal is to identify factors contributing to this evolution, as untreated NASH can progress from fibrosis to cirrhosis and ultimately be complicated by hepatocellular carcinoma (HCC). Several groups of drugs have undergone clinical trials for use as specific therapies for NAFLD; most of them are drugs used to treat type 2 diabetes mellitus (T2DM), which is one of the main risk factors for the development of NAFLD. Among the most studied of them are PPAR-γ agonists, the so-called thiazolidinediones (pioglitazone), glucagon-like peptide-1 receptor agonists (GLP-1R), and dipeptidyl peptidase-4 inhibitors (DPP-4). In fact, the most promising category is sodium-glucose cotransporter 2 inhibitors (SGCT2). We will consider the main pathogenetic mechanisms and modern methods of treating NAFLD, paying special attention to the use of SGLT2 inhibitors.
| Mualliflar | AGABABYAN Irina Rubenovna, JABBAROVA Nafisa Mamasolievna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2024-06-07 |
| Jild | 9 |
| Son | 2 |
стеатоз печени, НАЖБП, НАСГ, инсулинорезистентность, противодиабетические препараты, ингибитор НГЛТ2., hepatic steatosis, NAFLD, NASH, insulin resistance, antidiabetic drugs, SGLT2 inhibitor., jigar steatozi, AYJK, ASG, insulinga rezistentlik, diabetga qarshi dorilar, NGKT2 ingibitori.
In our article, the immunological changes observed in RA are important insights into the main mechanisms of the onset and progression of the disease. Antititans against rheumatoid factor (RF) and antititans against…
Atrial fibrillation (AF) is a very common heart rhythm disorder, which represents a pressing problem in modern arrhythmology. The incidence of AF has increased by 13% over the past 20 years. AF is associated with a high…
The article is devoted to identifying the features of high-resolution computed tomography in nonspecific interstitial pneumonia. According to the results of the study, radiation signs of pathology: widespread or local…
The article presents the results and conclusions of a study examining the importance of antifilaggrin antibodies in the diagnosis and prognosis of rheumatoid arthritis in the early period.
In this study, the properties of the subpopulation content of CD3+, CD4+, CD8+, CD4/CD8, CD56+, CD16+, CD25+, which have the ability to synthesize natural anti-inflammatory cytokines of the immune response in ra, were…
Atrial fibrillation (AF) is one of the unfavorable diseases of cardiology, because five times increases the risk of thromboembolic complications (TEC). AF is associated with a number of complications, such as…
In recent years, the number of patients with chronic heart failure who retain the left ventricular ejection fraction (SYEsCHF) has increased dramatically. In patients with ischemic SYEsCHF genesis, an increase in the…
The terminology and classification of fetal growth retardation syndrome (FGR) or fetal growth restriction syndrome (FGR) are presented, some issues of pathogenesis, risk factors, the role of functional diagnostic…
The results of the study include data on 118 patients who underwent complex diagnostics and surgical treatment of liver echinococcosis and its complications. A two-stage operation was recommended for patients in serious…
According to the literature, the lack of clear clinical manifestations of urolithiasis and calculous pyelonephritis in children is the cause of diagnostic errors in 8 - 32% of cases. The aim of the study was to identify…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar