Current issues in modern treatment of non-alcoholic fatty liver disease

AGABABYAN Irina Rubenovna, JABBAROVA Nafisa Mamasolievna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2024-yil

Annotatsiya

Non-alcoholic fatty liver disease (NAFLD), as one of the factors of metabolic syndrome (MS), is currently the most common liver disease worldwide. Currently, no specific drug therapy for this condition has been developed; its treatment is based on the treatment of the main risk factors. The initial accumulation of triglycerides in the liver parenchyma, in the presence of inflammatory processes, mitochondrial dysfunction, lipotoxicity, glucose toxicity and oxidative stress, can develop into non-alcoholic steatohepatitis (NASH). The primary goal is to identify factors contributing to this evolution, as untreated NASH can progress from fibrosis to cirrhosis and ultimately be complicated by hepatocellular carcinoma (HCC). Several groups of drugs have undergone clinical trials for use as specific therapies for NAFLD; most of them are drugs used to treat type 2 diabetes mellitus (T2DM), which is one of the main risk factors for the development of NAFLD. Among the most studied of them are PPAR-γ agonists, the so-called thiazolidinediones (pioglitazone), glucagon-like peptide-1 receptor agonists (GLP-1R), and dipeptidyl peptidase-4 inhibitors (DPP-4). In fact, the most promising category is sodium-glucose cotransporter 2 inhibitors (SGCT2). We will consider the main pathogenetic mechanisms and modern methods of treating NAFLD, paying special attention to the use of SGLT2 inhibitors.

Maqola ma’lumotlari
MualliflarAGABABYAN Irina Rubenovna, JABBAROVA Nafisa Mamasolievna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2024-06-07
Jild9
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

стеатоз печени, НАЖБП, НАСГ, инсулинорезистентность, противодиабетические препараты, ингибитор НГЛТ2., hepatic steatosis, NAFLD, NASH, insulin resistance, antidiabetic drugs, SGLT2 inhibitor., jigar steatozi, AYJK, ASG, insulinga rezistentlik, diabetga qarshi dorilar, NGKT2 ingibitori.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAGABABYAN Irina Rubenovna, & JABBAROVA Nafisa Mamasolievna (2024). CURRENT ISSUES IN MODERN TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(2). https://tadqiqot.uz/index.php/biomedicine/article/view/9468
GOST (OAK)AGABABYAN Irina Rubenovna, JABBAROVA Nafisa Mamasolievna CURRENT ISSUES IN MODERN TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2024. – T. 9, № 2.
MLAAGABABYAN Irina Rubenovna, and JABBAROVA Nafisa Mamasolievna. “CURRENT ISSUES IN MODERN TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(2), 2024. https://tadqiqot.uz/index.php/biomedicine/article/view/9468
ChicagoAGABABYAN Irina Rubenovna, and JABBAROVA Nafisa Mamasolievna. “CURRENT ISSUES IN MODERN TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(2) (2024). https://tadqiqot.uz/index.php/biomedicine/article/view/9468
HarvardAGABABYAN Irina Rubenovna, and JABBAROVA Nafisa Mamasolievna (2024) ‘CURRENT ISSUES IN MODERN TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 9(2). https://tadqiqot.uz/index.php/biomedicine/article/view/9468
BibTeX
@article{agababyanirinarubenovna2024,
  title = {CURRENT ISSUES IN MODERN TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE},
  author = {AGABABYAN Irina Rubenovna and JABBAROVA Nafisa Mamasolievna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2024},
  volume = {9},
  number = {2},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/9468}
}

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