Immunogenetic and cytokine markers for assessing immunoinflammatory responses in brucellosis

Urunova , Dilbar, Abdullayeva , Dilfuza

Жанубий оролбўйи тиббиёт журнали · 2026-yil

Annotatsiya

Brucellosis, a widespread zoonotic infection caused by Brucella species, continues to pose a substantial public health challenge, particularly in endemic areas. This paper examines the fundamental mechanisms involved in brucellosis pathogenesis, including pathogen recognition processes, immune evasion strategies utilized by Brucella, and the integrated roles of innate and adaptive immune responses in disease development. Particular attention is given to the ability of Brucella to alter host immune regulation, thereby promoting persistent and chronic infection. From an epidemiological perspective, the study addresses the major routes of transmission, associated risk factors, and the wider impact of brucellosis on global health. In addition, recent progress in diagnostic methodologies, especially molecular diagnostic tools and the identification of novel biomarkers, is reviewed to improve disease detection and monitoring. The paper also evaluates current therapeutic approaches, including standard antimicrobial regimens and emerging immunotherapeutic strategies, highlighting their challenges and future directions. By providing a clearer understanding of the molecular and immunological basis of brucellosis pathogenesis, this study emphasizes the value of multidisciplinary strategies in advancing diagnosis, treatment, prevention, and clinical management of this persistent infectious disease.

Maqola ma’lumotlari
MualliflarUrunova , Dilbar, Abdullayeva , Dilfuza
JurnalЖанубий оролбўйи тиббиёт журнали
NashriyotТТА Урганч филиали
ISSN3093-8740, 2012-2021
Nashr sanasi2026-07-30
Jild2
Son3/1
Betlar632-638
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

Brucellosis, host immune response, persistent (chronic) infection, diagnostic approaches

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUrunova , Dilbar, & Abdullayeva , Dilfuza (2026). IMMUNOGENETIC AND CYTOKINE MARKERS FOR ASSESSING IMMUNOINFLAMMATORY RESPONSES IN BRUCELLOSIS. Жанубий оролбўйи тиббиёт журнали, 2(3/1), 632-638. http://journal.urdti.uz/index/article/view/852
GOST (OAK)Urunova , Dilbar, Abdullayeva , Dilfuza IMMUNOGENETIC AND CYTOKINE MARKERS FOR ASSESSING IMMUNOINFLAMMATORY RESPONSES IN BRUCELLOSIS // Жанубий оролбўйи тиббиёт журнали. – 2026. – T. 2, № 3/1. – P. 632-638.
MLAUrunova , Dilbar, and Abdullayeva , Dilfuza. “IMMUNOGENETIC AND CYTOKINE MARKERS FOR ASSESSING IMMUNOINFLAMMATORY RESPONSES IN BRUCELLOSIS.” Жанубий оролбўйи тиббиёт журнали, 2(3/1), 632-638, 2026. http://journal.urdti.uz/index/article/view/852
ChicagoUrunova , Dilbar, and Abdullayeva , Dilfuza. “IMMUNOGENETIC AND CYTOKINE MARKERS FOR ASSESSING IMMUNOINFLAMMATORY RESPONSES IN BRUCELLOSIS.” Жанубий оролбўйи тиббиёт журнали, 2(3/1), 632-638 (2026). http://journal.urdti.uz/index/article/view/852
HarvardUrunova , Dilbar, and Abdullayeva , Dilfuza (2026) ‘IMMUNOGENETIC AND CYTOKINE MARKERS FOR ASSESSING IMMUNOINFLAMMATORY RESPONSES IN BRUCELLOSIS’, Жанубий оролбўйи тиббиёт журнали, 2(3/1), 632-638. http://journal.urdti.uz/index/article/view/852
BibTeX
@article{urunovadilbar2026,
  title = {IMMUNOGENETIC AND CYTOKINE MARKERS FOR ASSESSING IMMUNOINFLAMMATORY RESPONSES IN BRUCELLOSIS},
  author = {Urunova , Dilbar and Abdullayeva , Dilfuza},
  journal = {Жанубий оролбўйи тиббиёт журнали},
  year = {2026},
  volume = {2},
  number = {3/1},
  pages = {632-638},
  url = {http://journal.urdti.uz/index/article/view/852}
}

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