Chronic poisoning of rats with the organophosphate pesticide antio at doses of 3.5 mg/kg/day and 17.5 mg/kg/day (1/100 and 1/20 LD50, respectively) in the experiment revealed the presence of acetylcholinesterase activity in their lymphocytes. The results of the experiment showed that the activity of acetylcholinesterase is not the same in different subpopulations of lymphoid cells. The revealed dose-dependent inhibition of acetylcholinesterase in rat lymphocytes during chronic administration of the organophosphorus pesticide antio suggests that there may be a previously unknown mechanism of the immunosuppressive effect of organophosphorus compounds, implemented through the interference of these drugs in the processes of neurotransmitter regulation of the functions of lymphoid cells.
| Mualliflar | KHAYDAROVA Dilorom Safoevna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashriyot | Тошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ |
| ISSN | 2181-9300 |
| Nashr sanasi | 2022-08-30 |
| Jild | 7 |
| Son | 3 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-27 |
фосфорорганические пестициды, хроническое отравление, лимфоциты крыс, ацетилхолинэстеразная активность, угнетение ацетилхолинэстеразы, organophosphate pesticides, chronic poisoning, rat lymphocytes, acetylcholinesterase activity, acetylcholinesterase inhibition, fosfororganik pestitsid, surunkali zaharlanish, kalamush limfotsitlari, atsetilxolinesteraza faolligi, atsetilxolinesteraza tormozlanishi
| APA | KHAYDAROVA Dilorom Safoevna (2022). INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3). https://tadqiqot.uz/index.php/biomedicine/article/view/5391 |
|---|---|
| GOST (OAK) | KHAYDAROVA Dilorom Safoevna INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2022. – T. 7, № 3. |
| MLA | KHAYDAROVA Dilorom Safoevna. “INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3), 2022. https://tadqiqot.uz/index.php/biomedicine/article/view/5391 |
| Chicago | KHAYDAROVA Dilorom Safoevna. “INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3) (2022). https://tadqiqot.uz/index.php/biomedicine/article/view/5391 |
| Harvard | KHAYDAROVA Dilorom Safoevna (2022) ‘INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(3). https://tadqiqot.uz/index.php/biomedicine/article/view/5391 |
| BibTeX | @article{khaydarovadiloromsafoevna2022,
title = {INFLUENCE OF CHRONIC INTOXICATION WITH THE ORGANOPHOSPHORUS PESTICIDE ANTIO ON THE ACTIVITY OF RAT LYMPHOCYTE ACETYLCHOLINESTERASE},
author = {KHAYDAROVA Dilorom Safoevna},
journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
year = {2022},
volume = {7},
number = {3},
url = {https://tadqiqot.uz/index.php/biomedicine/article/view/5391}
} |
Boshqa maqola uchun iqtibos tayyorlash
Extensive and active natural plague foci with a total area of 19,1 million hectares (42% of the total territory of the country) are located on the territory of the Republic of Uzbekistan. In the conditions of continuous…
This article analyzes specific experiments on pigment metabolism, cytolysis, and cholestasis parameters to assess liver functional status in non-alcoholic fatty liver disease in middle-aged and elderly patients with…
Objective: to study the state of central hemodynamics in elderly patients according to echocardiography in order to identify the preclinical phase of chronic heart failure. Materials and methods: The study included…
This article presents a literary review of the problem of non-alcoholic fatty liver disease, which is a polyetiological disease. Excessive consumption of foods rich in animal fats and easily digestible carbohydrates…
Nowadays, energy drinks are widely used all over the world. It is no secret that there are lovers of such energy drinks who are attached to them. After all, these drinks temporarily give the body strength, energy…
There are data in the literature on the study of reactive changes in the endocrine cells of the epithelium of the intestinal mucosa under various influences, and today there are many unexplored issues, the reaction of…
Objective. Development of a well-informed and effective method based on the results of transcervical ultrasound examination in pharyngeal tonsils hypertrophy. Materials and methods. To achieve this aim, 164 patients…
According to M. S. Ignatov in the group of children with 3rd, 4th and 5th stages of "Chronic kidney disease" among the causes the congenital kidney diseases were prevailed. The determining factor for the choice of…
The purpose of the study: to determine the importance of computed tomography in patients with COVID-19. Materials and methods of research: the material for the study was the case histories of the results of computed…
Objective: To study the features of regional metastasis in melanoma and the optimal approach to their treatment. Methods: The study included data from 61 patients treated with a diagnosis of skin melanoma for the period…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2022-yil arxivi
Настоящее исследование посвящено разработке алгоритма раннего выявления сенсоневральной тугоухости у детей с использованием методов полимеразной цепной реакции (ПЦР). Обследовано 235 детей с нарушениями слуха, из…
В статье представлены клинические аспекты и диагностические проблемы выявления сенсоневральной тугоухости у новорождённых с перинатальной патологией. Обследовано 115 новорождённых, из которых 35 перенесли асфиксию, а у…
Сенсоневральная тугоухость (СНТ) у детей остаётся одной из наиболее актуальных проблем современной оториноларингологии и медицинской генетики. Ранняя диагностика нарушений слуха играет ключевую роль в предупреждении…
Сенсоневральная тугоухость у новорождённых является одной из ведущих причин нарушения слухоречевого развития и ранней инвалидизации. Наиболее уязвимыми считаются дети, перенёсшие перинатальные осложнения, такие как…
Mazkur eksperimental tadqiqotda yuqori yog‘li ratsion va seftriaksonning lipid hamda uglevod almashinuviga alohida va birgalikdagi ta’siri 160 ta oq zotsiz erkak kalamushda o‘rganildi. Tajriba hayvonlari to‘rtta guruhga…
Мазкур тадқиқотда Тошкет вилоятидаги Ўрта Чирчиқ тумани 25-сонли, Бўка тумани 3-сонли ва 9-сонли давлат мактабгача таълим ташкилотларида 2025 йил ёз мавсумидаги таомномаларнинг озиқ-овқат маҳсулотлари билан…