Depression in parkinson's disease: the determining role of disease stage and motor deficit

Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina, Исраилова, Гуллола, Исроилова, Гулрухсора, Сайфитдинхужаев, Зайнутдинхужа, Насирдинова, Наргиса, Кучкарова, Одина, Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina

Халқаро илмий педиатрия журнали · 2026-yil

Annotatsiya

Introduction. Depression is a frequent non-motor manifestation of Parkinson's disease (PD), significantly affecting patients' quality of life and prognosis. The aim of the study the prevalence of depression using the HADS scale and its associations with clinical and demographic parameters in PD patients. Materials and Methods. A total of 153 PD patients were examined. The assessment tools included Part III of the Unified Parkinson's Disease Rating Scale (UPDRS-III) for motor evaluation and the Hospital Anxiety and Depression Scale (HADS) for depression screening. Patients were categorized based on HADS scores into groups: no depression (0-7), subclinical depression (8-10), and clinical depression (≥11). Results and Discussion. Subclinical depression was identified in 68.6% (n=105) of patients, while clinical depression was found in 9.9% (n=15). Age and gender did not differ significantly between the groups (p>0.05). Strong positive correlations were established between the depression score and the Hoehn & Yahr stage (p=0.00043) as well as the UPDRS-III score (p=0.002). In the multivariate regression model, the PD stage was a borderline significant predictor of clinical depression (p=0.065). Conclusions. Depression in PD is predominantly subclinical and is strongly associated with the severity of motor deficit and disease stage. This justifies the rationale for implementing stage-oriented screening for depression in this patient population.

Maqola ma’lumotlari
MualliflarIsroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina, Исраилова, Гуллола, Исроилова, Гулрухсора, Сайфитдинхужаев, Зайнутдинхужа, Насирдинова, Наргиса, Кучкарова, Одина, Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2026-02-18
Jild5
Son1
Betlar1228-1234
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2026-5-1-1228-1234
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2026-5-1-1228-1234 · Maqolaning asl sahifasi

Kalit so‘zlar

аффективные расстройства, болезнь Паркинсона, депрессия, качество жизни, affective disorders, depression, Parkinson's disease, quality of life, affektiv kasalliklar, Parkinson kasalligi, depressiya, hayot sifati

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAIsroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina, Исраилова, Гуллола, Исроилова, Гулрухсора, Сайфитдинхужаев, Зайнутдинхужа, Насирдинова, Наргиса, Кучкарова, Одина, Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, & Quchkarova, Odina (2026). DEPRESSION IN PARKINSON'S DISEASE: THE DETERMINING ROLE OF DISEASE STAGE AND MOTOR DEFICIT. Халқаро илмий педиатрия журнали, 5(1), 1228-1234. https://doi.org/10.56121/2181-2926-2026-5-1-1228-1234
GOST (OAK)Isroilova, Gullola va b. DEPRESSION IN PARKINSON'S DISEASE: THE DETERMINING ROLE OF DISEASE STAGE AND MOTOR DEFICIT // Халқаро илмий педиатрия журнали. – 2026. – T. 5, № 1. – P. 1228-1234. – DOI: 10.56121/2181-2926-2026-5-1-1228-1234.
MLAIsroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina, Исраилова, Гуллола, Исроилова, Гулрухсора, Сайфитдинхужаев, Зайнутдинхужа, Насирдинова, Наргиса, Кучкарова, Одина, Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, and Quchkarova, Odina. “DEPRESSION IN PARKINSON'S DISEASE: THE DETERMINING ROLE OF DISEASE STAGE AND MOTOR DEFICIT.” Халқаро илмий педиатрия журнали, 5(1), 1228-1234, 2026. https://doi.org/10.56121/2181-2926-2026-5-1-1228-1234
ChicagoIsroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina, Исраилова, Гуллола, Исроилова, Гулрухсора, Сайфитдинхужаев, Зайнутдинхужа, Насирдинова, Наргиса, Кучкарова, Одина, Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, and Quchkarova, Odina. “DEPRESSION IN PARKINSON'S DISEASE: THE DETERMINING ROLE OF DISEASE STAGE AND MOTOR DEFICIT.” Халқаро илмий педиатрия журнали, 5(1), 1228-1234 (2026). https://doi.org/10.56121/2181-2926-2026-5-1-1228-1234
HarvardIsroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, Quchkarova, Odina, Исраилова, Гуллола, Исроилова, Гулрухсора, Сайфитдинхужаев, Зайнутдинхужа, Насирдинова, Наргиса, Кучкарова, Одина, Isroilova, Gullola, Isroilova, Gulrukhsora, Saifitdinkhuzhaev, Zaynutdinkhuzha, Nasirdinova, Nargisa, and Quchkarova, Odina (2026) ‘DEPRESSION IN PARKINSON'S DISEASE: THE DETERMINING ROLE OF DISEASE STAGE AND MOTOR DEFICIT’, Халқаро илмий педиатрия журнали, 5(1), 1228-1234. https://doi.org/10.56121/2181-2926-2026-5-1-1228-1234
BibTeX
@article{isroilovagullola2026,
  title = {DEPRESSION IN PARKINSON'S DISEASE: THE DETERMINING ROLE OF DISEASE STAGE AND MOTOR DEFICIT},
  author = {Isroilova, Gullola and Isroilova, Gulrukhsora and Saifitdinkhuzhaev, Zaynutdinkhuzha and Nasirdinova, Nargisa and Quchkarova, Odina and Исраилова, Гуллола and Исроилова, Гулрухсора and Сайфитдинхужаев, Зайнутдинхужа and Насирдинова, Наргиса and Кучкарова, Одина and Isroilova, Gullola and Isroilova, Gulrukhsora and Saifitdinkhuzhaev, Zaynutdinkhuzha and Nasirdinova, Nargisa and Quchkarova, Odina},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2026},
  volume = {5},
  number = {1},
  pages = {1228-1234},
  doi = {10.56121/2181-2926-2026-5-1-1228-1234},
  url = {https://doi.org/10.56121/2181-2926-2026-5-1-1228-1234}
}

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