Integrating neurophysiological and paraclinical findings for differential diagnosis of subacute sclerosing panencephalitis in pediatric patients

Saidazizova, Shakhlo, Inomov, Firdavs, Саидазизова, Шахло, Иномов, Фирдавс, Saidazizova, Shaxlo, Inomov, Firdavs

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

Relevance. Subacute sclerosing panencephalitis (SSPE) remains a devastating progressive encephalopathy in children, caused by persistent measles virus infection. Accurate differential diagnosis requires integrating clinical, neurophysiological, and paraclinical data. Materials and methods.This study analyzed 180 pediatric SSPE patients treated at the Center for the Development of Professional Qualification of Medical Workers and the National Children’s Medical Center between 2019 and 2024. Data included demographics, vaccination status, disease severity, electroencephalography (EEG), and magnetic resonance imaging (MRI). Results: Characteristic EEG periodic complexes and MRI white-matter abnormalities strongly correlated with clinical stage and functional decline. Vaccination coverage was low (40%), highlighting persistent susceptibility to measles-related complications. Our findings confirm that combining EEG, MRI, and cerebrospinal fluid antibody testing increases diagnostic certainty and distinguishes SSPE from mimicking neurological conditions. Conclusion. Early recognition through multimodal assessment is essential for timely management, counseling, and trial enrollment. Strengthening vaccination strategies and standardized diagnostic protocols may reduce disease burden and improve outcomes.

Maqola ma’lumotlari
MualliflarSaidazizova, Shakhlo, Inomov, Firdavs, Саидазизова, Шахло, Иномов, Фирдавс, Saidazizova, Shaxlo, Inomov, Firdavs
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-11-04
Jild4
Son5
Betlar1093-1097
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-5-1093-1097
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-5-1093-1097 · Maqolaning asl sahifasi

Kalit so‘zlar

ПСПЭ, детская неврология, ЭЭГ, МРТ, корь, диагностика, SSPE, pediatric neurology, EEG, MRI, measles, diagnosis, O‘SSP, bolalar nevrologiyasi, EEG, MRT, qizamiq, tashxis

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APASaidazizova, Shakhlo, Inomov, Firdavs, Саидазизова, Шахло, Иномов, Фирдавс, Saidazizova, Shaxlo, & Inomov, Firdavs (2025). INTEGRATING NEUROPHYSIOLOGICAL AND PARACLINICAL FINDINGS FOR DIFFERENTIAL DIAGNOSIS OF SUBACUTE SCLEROSING PANENCEPHALITIS IN PEDIATRIC PATIENTS. Халқаро илмий педиатрия журнали, 4(5), 1093-1097. https://doi.org/10.56121/2181-2926-2025-4-5-1093-1097
GOST (OAK)Saidazizova, Shakhlo va b. INTEGRATING NEUROPHYSIOLOGICAL AND PARACLINICAL FINDINGS FOR DIFFERENTIAL DIAGNOSIS OF SUBACUTE SCLEROSING PANENCEPHALITIS IN PEDIATRIC PATIENTS // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 5. – P. 1093-1097. – DOI: 10.56121/2181-2926-2025-4-5-1093-1097.
MLASaidazizova, Shakhlo, Inomov, Firdavs, Саидазизова, Шахло, Иномов, Фирдавс, Saidazizova, Shaxlo, and Inomov, Firdavs. “INTEGRATING NEUROPHYSIOLOGICAL AND PARACLINICAL FINDINGS FOR DIFFERENTIAL DIAGNOSIS OF SUBACUTE SCLEROSING PANENCEPHALITIS IN PEDIATRIC PATIENTS.” Халқаро илмий педиатрия журнали, 4(5), 1093-1097, 2025. https://doi.org/10.56121/2181-2926-2025-4-5-1093-1097
ChicagoSaidazizova, Shakhlo, Inomov, Firdavs, Саидазизова, Шахло, Иномов, Фирдавс, Saidazizova, Shaxlo, and Inomov, Firdavs. “INTEGRATING NEUROPHYSIOLOGICAL AND PARACLINICAL FINDINGS FOR DIFFERENTIAL DIAGNOSIS OF SUBACUTE SCLEROSING PANENCEPHALITIS IN PEDIATRIC PATIENTS.” Халқаро илмий педиатрия журнали, 4(5), 1093-1097 (2025). https://doi.org/10.56121/2181-2926-2025-4-5-1093-1097
HarvardSaidazizova, Shakhlo, Inomov, Firdavs, Саидазизова, Шахло, Иномов, Фирдавс, Saidazizova, Shaxlo, and Inomov, Firdavs (2025) ‘INTEGRATING NEUROPHYSIOLOGICAL AND PARACLINICAL FINDINGS FOR DIFFERENTIAL DIAGNOSIS OF SUBACUTE SCLEROSING PANENCEPHALITIS IN PEDIATRIC PATIENTS’, Халқаро илмий педиатрия журнали, 4(5), 1093-1097. https://doi.org/10.56121/2181-2926-2025-4-5-1093-1097
BibTeX
@article{saidazizovashakhlo2025,
  title = {INTEGRATING NEUROPHYSIOLOGICAL AND PARACLINICAL FINDINGS FOR DIFFERENTIAL DIAGNOSIS OF SUBACUTE SCLEROSING PANENCEPHALITIS IN PEDIATRIC PATIENTS},
  author = {Saidazizova, Shakhlo and Inomov, Firdavs and Саидазизова, Шахло and Иномов, Фирдавс and Saidazizova, Shaxlo and Inomov, Firdavs},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {5},
  pages = {1093-1097},
  doi = {10.56121/2181-2926-2025-4-5-1093-1097},
  url = {https://doi.org/10.56121/2181-2926-2025-4-5-1093-1097}
}

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