Cardiovascular disorders in children with juvenile arthritis: the importance of inflammation activity and disease duration

Akhmedova, Nilufar, Saydalieva, Farangiz, Ахмедова, Нилуфар, Сайдалиева, Фарангиз, Axmedova, Nilufar, Saydalieva, Farangiz

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

Relevance. Under the influence of progressive inflammatory activity, immunological disturbances, and pharmacological therapy, cardiovascular system damage in children with juvenile arthritis is considered one of the leading factors contributing to a poorer prognosis and increased risk of disability. The clinical manifestations of such disorders are often masked by the underlying disease, which leads to a delay in diagnosis. This highlights the necessity of a detailed investigation of cardiovascular abnormalities in this patient population. Objective. To assess the impact of inflammatory activity and disease duration of juvenile arthritis on the development of cardiovascular disorders in children. Materials and Methods. The study included 80 patients with JIA aged 2 to 17 years, divided into two groups: 50 with systemic-onset JIA and 30 with the articular form of the disease. Clinical, instrumental, and laboratory methods were applied. Statistical analysis of the data was performed using IBM SPSS Statistics v.26. Results. It was established that the frequency of cardiovascular disorders in children with systemic-onset JIA was higher than in those with the articular form. The following characteristic cardiovascular disorders were identified: chronic heart failure, myocardial remodeling, arrhythmias, conduction blocks, left ventricular hypertrophy, and decreased contractile function. A significant association was demonstrated between the frequency of these disorders, the severity of inflammatory activity, and disease duration. Conclusion. In children with systemic-onset JIA, cardiovascular disorders are more frequent compared to the articular form. The progression and high inflammatory activity of JIA are closely related to the development of structural and functional cardiac changes, including myocardial remodeling, conduction abnormalities, and valvular dysfunctions.

Maqola ma’lumotlari
MualliflarAkhmedova, Nilufar, Saydalieva, Farangiz, Ахмедова, Нилуфар, Сайдалиева, Фарангиз, Axmedova, Nilufar, Saydalieva, Farangiz
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-11-04
Jild4
Son5
Betlar1072-1077
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-5-1072-1077
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-5-1072-1077 · Maqolaning asl sahifasi

Kalit so‘zlar

дети, ювенильный артрит, рдечно-сосудистые нарушения, сердечная недостаточность, ремоделирование миокарда, активность заболевания, children, juvenile idiopathic arthritis, cardiovascular disorders, heart failure, myocardial remodeling, disease activity, bolalar, yuvenil artrit, yurak-qon tomir buzilishlari, ak yetishmovchiligi, miokardni remodellanishi, kasallik faolligi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAkhmedova, Nilufar, Saydalieva, Farangiz, Ахмедова, Нилуфар, Сайдалиева, Фарангиз, Axmedova, Nilufar, & Saydalieva, Farangiz (2025). CARDIOVASCULAR DISORDERS IN CHILDREN WITH JUVENILE ARTHRITIS: THE IMPORTANCE OF INFLAMMATION ACTIVITY AND DISEASE DURATION. Халқаро илмий педиатрия журнали, 4(5), 1072-1077. https://doi.org/10.56121/2181-2926-2025-4-5-1072-1077
GOST (OAK)Akhmedova, Nilufar va b. CARDIOVASCULAR DISORDERS IN CHILDREN WITH JUVENILE ARTHRITIS: THE IMPORTANCE OF INFLAMMATION ACTIVITY AND DISEASE DURATION // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 5. – P. 1072-1077. – DOI: 10.56121/2181-2926-2025-4-5-1072-1077.
MLAAkhmedova, Nilufar, Saydalieva, Farangiz, Ахмедова, Нилуфар, Сайдалиева, Фарангиз, Axmedova, Nilufar, and Saydalieva, Farangiz. “CARDIOVASCULAR DISORDERS IN CHILDREN WITH JUVENILE ARTHRITIS: THE IMPORTANCE OF INFLAMMATION ACTIVITY AND DISEASE DURATION.” Халқаро илмий педиатрия журнали, 4(5), 1072-1077, 2025. https://doi.org/10.56121/2181-2926-2025-4-5-1072-1077
ChicagoAkhmedova, Nilufar, Saydalieva, Farangiz, Ахмедова, Нилуфар, Сайдалиева, Фарангиз, Axmedova, Nilufar, and Saydalieva, Farangiz. “CARDIOVASCULAR DISORDERS IN CHILDREN WITH JUVENILE ARTHRITIS: THE IMPORTANCE OF INFLAMMATION ACTIVITY AND DISEASE DURATION.” Халқаро илмий педиатрия журнали, 4(5), 1072-1077 (2025). https://doi.org/10.56121/2181-2926-2025-4-5-1072-1077
HarvardAkhmedova, Nilufar, Saydalieva, Farangiz, Ахмедова, Нилуфар, Сайдалиева, Фарангиз, Axmedova, Nilufar, and Saydalieva, Farangiz (2025) ‘CARDIOVASCULAR DISORDERS IN CHILDREN WITH JUVENILE ARTHRITIS: THE IMPORTANCE OF INFLAMMATION ACTIVITY AND DISEASE DURATION’, Халқаро илмий педиатрия журнали, 4(5), 1072-1077. https://doi.org/10.56121/2181-2926-2025-4-5-1072-1077
BibTeX
@article{akhmedovanilufar2025,
  title = {CARDIOVASCULAR DISORDERS IN CHILDREN WITH JUVENILE ARTHRITIS: THE IMPORTANCE OF INFLAMMATION ACTIVITY AND DISEASE DURATION},
  author = {Akhmedova, Nilufar and Saydalieva, Farangiz and Ахмедова, Нилуфар and Сайдалиева, Фарангиз and Axmedova, Nilufar and Saydalieva, Farangiz},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {5},
  pages = {1072-1077},
  doi = {10.56121/2181-2926-2025-4-5-1072-1077},
  url = {https://doi.org/10.56121/2181-2926-2025-4-5-1072-1077}
}

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