Investigation of the dose-dependent antihypertensive effects of gkmkt:naringenin 4:1 and gkmkt:apigenin 4:1 complexes and extracts of phlomoides isochila and pyrus pyraster in an experimental hypertension model

XASANOVA, Dilfuza, XAYITBAYEV, Azamat, RAXMONOV, Bobur, ESANOV, Rahmat

Ўзбекистон Миллий университети хабарлари · 2026-yil

Annotatsiya

This study investigated the antihypertensive activity of MPSGA (Mono-potassium salt of glycyrrhizic acid):Naringenin 4:1 andMPSGA:Apigenin 4:1 complexes, as well as extracts obtained from Phlomoides isochila (IM-1) and Pyrus pyraster fruits, in anexperimental model of hypertension. The experiments were performed on outbred white rats weighing 190–200 g. Arterial bloodpressure was measured non-invasively using the Tail Cuff method. The tested compounds were administered at doses of 20, 40,and 60 mg/kg, and their effects on systolic and diastolic blood pressure parameters were comparatively evaluated.

Maqola ma’lumotlari
MualliflarXASANOVA, Dilfuza, XAYITBAYEV, Azamat, RAXMONOV, Bobur, ESANOV, Rahmat
JurnalЎзбекистон Миллий университети хабарлари
NashriyotЎзбекистон Миллий университети
ISSN2181-7324, 3093-8996
Nashr sanasi2026-09-21
Jild3
Son3.3
Betlar122-125
TilIngliz
Indeksga qo‘shilgan2026-09-22

Maqolaning asl sahifasi

Kalit so‘zlar

arterial hypertension, antihypertensive activity, MPSGA:Naringenin 4:1, MPSGA:Apigenin 4:1, Phlomoides isochila, Pyrus pyraster, arterial blood pressure, systolic blood pressure, diastolic blood pressure, Tail Cuff method, dose-dependent effect., артериальная гипертензия, антигипертензивная активность, МКСГК:Нарингенин 4:1, МКГСК:Апигенин 4:1, Phlomoides isochila (IM-1), Pyrus pyraster (Дикая груша), артериальное давление, систолическое давление, диастолическое давление, метод Tail Cuff, дозозависимый эффект., arterial gipertenziya, antigipertenziv faollik, GKMKT:Naringenin 4:1, GKMKT:Apigenin 4:1, Phlomoides isochila, Pyrus pyraster, arterial qon bosimi, sistolik bosim, diastolik bosim, Tail Cuff usuli, dozaga bog‘liq ta’sir.

Iqtibos keltirish

APAXASANOVA, Dilfuza, XAYITBAYEV, Azamat, RAXMONOV, Bobur, & ESANOV, Rahmat (2026). INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL. Ўзбекистон Миллий университети хабарлари, 3(3.3), 122-125. https://journals.nuu.uz/index.php/actanuuz/article/view/14976
GOST (OAK)XASANOVA, Dilfuza va b. INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL // Ўзбекистон Миллий университети хабарлари. – 2026. – T. 3, № 3.3. – P. 122-125.
MLAXASANOVA, Dilfuza, XAYITBAYEV, Azamat, RAXMONOV, Bobur, and ESANOV, Rahmat. “INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL.” Ўзбекистон Миллий университети хабарлари, 3(3.3), 122-125, 2026. https://journals.nuu.uz/index.php/actanuuz/article/view/14976
ChicagoXASANOVA, Dilfuza, XAYITBAYEV, Azamat, RAXMONOV, Bobur, and ESANOV, Rahmat. “INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL.” Ўзбекистон Миллий университети хабарлари, 3(3.3), 122-125 (2026). https://journals.nuu.uz/index.php/actanuuz/article/view/14976
HarvardXASANOVA, Dilfuza, XAYITBAYEV, Azamat, RAXMONOV, Bobur, and ESANOV, Rahmat (2026) ‘INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL’, Ўзбекистон Миллий университети хабарлари, 3(3.3), 122-125. https://journals.nuu.uz/index.php/actanuuz/article/view/14976
BibTeX
@article{xasanovadilfuza2026,
  title = {INVESTIGATION OF THE DOSE-DEPENDENT ANTIHYPERTENSIVE EFFECTS OF GKMKT:NARINGENIN 4:1 AND GKMKT:APIGENIN 4:1 COMPLEXES AND EXTRACTS OF PHLOMOIDES ISOCHILA AND PYRUS PYRASTER IN AN EXPERIMENTAL HYPERTENSION MODEL},
  author = {XASANOVA, Dilfuza and XAYITBAYEV, Azamat and RAXMONOV, Bobur and ESANOV, Rahmat},
  journal = {Ўзбекистон Миллий университети хабарлари},
  year = {2026},
  volume = {3},
  number = {3.3},
  pages = {122-125},
  url = {https://journals.nuu.uz/index.php/actanuuz/article/view/14976}
}

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