Effects of heparin and clexane combined with contrykal on sterile inflammation during early pregnancy in the absence of genital infections

K.O. Muxitdinova, V.A. Aleynik, D.K Najmutdinova, S.M. Babich, B.M. Zhurayev

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

This study investigated the effects of heparin and low-molecular-weight heparin (Clexane) administered in combination with Contrykal on markers of sterile inflammation during early pregnancy in women without genital infections. The results demonstrated that the dynamics of HMGB1, IL-1α, and IL-33 varied considerably according to the type of preconception therapy. In Group 1 (standard treatment) and Group 2 (standard treatment plus antibiotics), these inflammatory markers increased as early as the sixth week of gestation and reached the highest absolute concentrations, indicating that empirical antibiotic therapy provided no significant anti-inflammatory or immunomodulatory benefit. In Groups 3 (Clexane) and 4 (Clexane plus Contrykal), activation of HMGB1 occurred predominantly by the twelfth week of pregnancy, suggesting that low-molecular-weight heparin, particularly when combined with Contrykal, delayed the development of sterile inflammatory responses. In Groups 5 (unfractionated heparin) and 6 (unfractionated heparin plus Contrykal), all three inflammatory markers increased significantly by the twelfth week; however, their concentrations remained substantially lower than those observed in Groups 1 and 2. The greatest inhibitory effect on HMGB1, IL-1α, and IL-33 was observed in women receiving the combination of unfractionated heparin and Contrykal. Serum uric acid concentrations showed no significant gestational changes but demonstrated stable intergroup differences, with unfractionated heparin, particularly when combined with Contrykal, being associated with lower baseline uric acid levels.

Maqola ma’lumotlari
MualliflarK.O. Muxitdinova, V.A. Aleynik, D.K Najmutdinova, S.M. Babich, B.M. Zhurayev
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-07-23
Jild14
Son3
Betlar289-296
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.081
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.081 · Maqolaning asl sahifasi · PDF

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Tibbiyot

Iqtibos keltirish

APAK.O. Muxitdinova, V.A. Aleynik, D.K Najmutdinova, S.M. Babich, & B.M. Zhurayev (2026). EFFECTS OF HEPARIN AND CLEXANE COMBINED WITH CONTRYKAL ON STERILE INFLAMMATION DURING EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 289-296. https://doi.org/10.67519/nshr.ztj.2026.03.081
GOST (OAK)K.O. Muxitdinova va b. EFFECTS OF HEPARIN AND CLEXANE COMBINED WITH CONTRYKAL ON STERILE INFLAMMATION DURING EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 289-296. – DOI: 10.67519/nshr.ztj.2026.03.081.
MLAK.O. Muxitdinova, V.A. Aleynik, D.K Najmutdinova, S.M. Babich, and B.M. Zhurayev. “EFFECTS OF HEPARIN AND CLEXANE COMBINED WITH CONTRYKAL ON STERILE INFLAMMATION DURING EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 289-296, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.081
ChicagoK.O. Muxitdinova, V.A. Aleynik, D.K Najmutdinova, S.M. Babich, and B.M. Zhurayev. “EFFECTS OF HEPARIN AND CLEXANE COMBINED WITH CONTRYKAL ON STERILE INFLAMMATION DURING EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 289-296 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.081
HarvardK.O. Muxitdinova, V.A. Aleynik, D.K Najmutdinova, S.M. Babich, and B.M. Zhurayev (2026) ‘EFFECTS OF HEPARIN AND CLEXANE COMBINED WITH CONTRYKAL ON STERILE INFLAMMATION DURING EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 289-296. https://doi.org/10.67519/nshr.ztj.2026.03.081
BibTeX
@article{komuxitdinova2026,
  title = {EFFECTS OF HEPARIN AND CLEXANE COMBINED WITH CONTRYKAL ON STERILE INFLAMMATION DURING EARLY PREGNANCY IN THE ABSENCE OF GENITAL INFECTIONS},
  author = {K.O. Muxitdinova and V.A. Aleynik and D.K Najmutdinova and S.M. Babich and B.M. Zhurayev},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {289-296},
  doi = {10.67519/nshr.ztj.2026.03.081},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.081}
}

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