Preeclampsia is a serious complication of pregnancy that affects the health of both mother and fetus. The aim of the study was to study the role of the most studied gene polymorphisms responsible for the regulation of vascular tone and endothelial dysfunction with the risk of preeclampsia. The results of the study showed the presence in the NOS3 gene structure of risk (G allele/GG genotype) and protective (T allele) markers in the development of PE. The carriage of the mutant allele T of the rs1799998 polymorphism of the aldosterone synthase gene is also associated with the risk of developing PE. Haplotype analysis of these loci revealed the presence of risky TG (P=0.02, OR=1.7) and protective CT (P=0.015, OR=0.21) haplotypes in the development of PE.
| Mualliflar | Нишанова Фируза Пулатовна, Хегай Татьяна Рудольфовна, Каримова Лутфия Азизовна |
|---|---|
| Jurnal | Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) |
| Nashr sanasi | 2023-09-21 |
| Jild | 4 |
| Son | 3 |
| Til | Rus |
преэклампсия, гены сосудистого тонуса, гены эндотелиальной дисфункции, preeclampsia, vascular tone genes, endothelial dysfunction genes, preeklampsiya, qon tomir tonus genlari, endotelial disfunksiya genlari
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