Insulin resistance and subclinical inflammation in gestational diabetes mellitus: association with the development of preeclampsia

Надырханова Наталья Суратовна, Каримова Лутфия Азизовна, Нишанова Фируза Пулатовна, Тожиева Ирода Мирсоли кизи

Марказий Осиё эндокринологик журнали · 2026-yil

Annotatsiya

Relevance: Gestational diabetes mellitus (GDM) is a well-established risk factor for preeclampsia. However, the predictive value of insulin resistance and subclinical inflammation markers in women with established GDM remains insufficiently investigated. Purpose: To evaluate the association of insulin resistance and subclinical inflammation markers with the development of preeclampsia in pregnant women with GDM and to assess their predictive significance. Materials and methods: A retrospective analysis was performed in a prospective cohort of 192 pregnant women with GDM identified during a multicenter screening study conducted in six regions of the Republic of Uzbekistan. Body mass index (BMI), insulin levels, HOMA-IR index, C-reactive protein (CRP), and ferritin levels were assessed. Correlation analysis, odds ratio estimation, and ROC analysis were performed. Results: Preeclampsia developed in 10 of 192 women (5.2%). Women who subsequently developed preeclampsia had significantly higher BMI, HOMA-IR, CRP, and ferritin levels compared with women without preeclampsia (all p<0.05). CRP demonstrated the highest predictive performance (AUC=0.790). A combined model including HOMA-IR, CRP, and ferritin showed superior predictive accuracy with an AUC of 0.817. Conclusion: The development of preeclampsia in women with GDM is associated with increased insulin resistance and subclinical inflammation. Combined assessment of HOMA-IR, CRP, and ferritin may improve risk stratification and facilitate early identification of women at high risk of preeclampsia.

Maqola ma’lumotlari
MualliflarНадырханова Наталья Суратовна, Каримова Лутфия Азизовна, Нишанова Фируза Пулатовна, Тожиева Ирода Мирсоли кизи
JurnalМарказий Осиё эндокринологик журнали
NashriyotРеспублика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази
ISSN2181-3426
Nashr sanasi2026-06-27
Jild6
Son2
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

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Kalit so‘zlar

гестационный сахарный диабет, преэклампсия, инсулинорезистентность, НОМА-ИР, С-реактивный белок, ферритин, индекс массы тела, gestational diabetes mellitus, preeclampsia, insulin resistance, HOMA-IR, C-reactive protein, ferritin, body mass index, gestatsion qandli diabet, preeklampsiya, insulinrezistentlik, HOMA-IR, C-reaktiv oqsil, ferritin, tana vazni indeksi

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Iqtibos keltirish

APAНадырханова Наталья Суратовна, Каримова Лутфия Азизовна, Нишанова Фируза Пулатовна, & Тожиева Ирода Мирсоли кизи (2026). INSULIN RESISTANCE AND SUBCLINICAL INFLAMMATION IN GESTATIONAL DIABETES MELLITUS: ASSOCIATION WITH THE DEVELOPMENT OF PREECLAMPSIA. Марказий Осиё эндокринологик журнали, 6(2). https://www.tadqiqot.uz/index.php/cae/article/view/14396
GOST (OAK)Надырханова Наталья Суратовна va b. INSULIN RESISTANCE AND SUBCLINICAL INFLAMMATION IN GESTATIONAL DIABETES MELLITUS: ASSOCIATION WITH THE DEVELOPMENT OF PREECLAMPSIA // Марказий Осиё эндокринологик журнали. – 2026. – T. 6, № 2.
MLAНадырханова Наталья Суратовна, Каримова Лутфия Азизовна, Нишанова Фируза Пулатовна, and Тожиева Ирода Мирсоли кизи. “INSULIN RESISTANCE AND SUBCLINICAL INFLAMMATION IN GESTATIONAL DIABETES MELLITUS: ASSOCIATION WITH THE DEVELOPMENT OF PREECLAMPSIA.” Марказий Осиё эндокринологик журнали, 6(2), 2026. https://www.tadqiqot.uz/index.php/cae/article/view/14396
ChicagoНадырханова Наталья Суратовна, Каримова Лутфия Азизовна, Нишанова Фируза Пулатовна, and Тожиева Ирода Мирсоли кизи. “INSULIN RESISTANCE AND SUBCLINICAL INFLAMMATION IN GESTATIONAL DIABETES MELLITUS: ASSOCIATION WITH THE DEVELOPMENT OF PREECLAMPSIA.” Марказий Осиё эндокринологик журнали, 6(2) (2026). https://www.tadqiqot.uz/index.php/cae/article/view/14396
HarvardНадырханова Наталья Суратовна, Каримова Лутфия Азизовна, Нишанова Фируза Пулатовна, and Тожиева Ирода Мирсоли кизи (2026) ‘INSULIN RESISTANCE AND SUBCLINICAL INFLAMMATION IN GESTATIONAL DIABETES MELLITUS: ASSOCIATION WITH THE DEVELOPMENT OF PREECLAMPSIA’, Марказий Осиё эндокринологик журнали, 6(2). https://www.tadqiqot.uz/index.php/cae/article/view/14396
BibTeX
@article{article2026,
  title = {INSULIN RESISTANCE AND SUBCLINICAL INFLAMMATION IN GESTATIONAL DIABETES MELLITUS: ASSOCIATION WITH THE DEVELOPMENT OF PREECLAMPSIA},
  author = {Надырханова Наталья Суратовна and Каримова Лутфия Азизовна and Нишанова Фируза Пулатовна and Тожиева Ирода Мирсоли кизи},
  journal = {Марказий Осиё эндокринологик журнали},
  year = {2026},
  volume = {6},
  number = {2},
  url = {https://www.tadqiqot.uz/index.php/cae/article/view/14396}
}

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