Relevance. According to the literature sources, POAG explore how etiological and pathogenetic factors arise, among which the leading role is given to genetic predisposition, general changes, ischemia, primary characteristic and dystrophic changes, disturbances in hydrostatics and hydrodynamics of the eyes, increased intraocular pressure, vascular disorders, dystrophy and tissue degeneration. Purpose of the study. The aim of the work is to evaluate the severity of endothelial dysfunction in patients with different stages of the course of primary open-angle glaucoma during complex therapy. Material and research methods. The study included 92 patients with primary open-angle glaucoma (POAG) aged 65 to 80 years, who were divided into three groups. We studied the levels of endothelin‑1, VEGF and von Willebrand factor before and after the recommended treatment in patients with POAG. Conclusion. The features of changes in ED markers in patients with POAG have been established; low levels of von Willebrand factor, VEGF and endothelin‑1, which indicates the role of pathogenetic factors in the formation of endothelial dysfunction and the importance of studying markers of endothelial dysfunction. The developed complex therapy of various stages in patients with POAG contributed to the correction of the identified disorders in relation to markers of endothelial dysfunction.
| Mualliflar | Д. М. Туйчибаева, А.М. Дусмухамедова |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-07-07 |
| Jild | 4 |
| Son | 4 |
| Betlar | 38-43 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.4.4.006 |
DOI: 10.57231/j.ao.2023.4.4.006 · Maqolaning asl sahifasi · PDF
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