Synthesis of esters of halogenoacetic acids

Kimyo va kimyo texnologiyasi · 2020-yil

Annotatsiya

Amidoalkylating reagents containing a phthalimide group are used in the synthesis of hard-to-reach primary amines and complex heterocyclic compounds. These types of amidoalkylating compounds are suitable reagents for nucleophilic substituted reactions in acidic media due to their resistance to acids. Result of reactions of amidoalkylating reagents-N-hydroxyethylphthalimide and N-hydroxymethylphthalimide with aliphatic carbonic acids can also produce new bactericidal and fungicidal esters. In this study, halogen acids reacted with N-hydroxymethylphthalimide monochloric acetic acid, monobromic acetic acid, monoiodic acetic acid, trifluoric acetic acid and trichloroacetic acid, as well as, N-b-hydroxyethylphthaleidyl monohydric acid. As a result of the reactions, new phthalimidomethyl and phthalimidoethyl esters of haloacetic acids were synthesized. The physical properties of crystalline esters have been determined. The structure of these compounds were confirmed by the analysis of their IR and PMR spectra. The esterification reactions of halogenated acetic acids were carried out in a benzene solvent and a sulfuric acid catalyst with primary alcohols, N-hydroxymethylphthalimide and N-β- beta hydroxyethylphthalimide,. It was found that in a benzene solvent, which increases the rate of bimolecular nucleophilic exchange in primary alcohols, phthalimidoethyl esters of halogen acid are formed in high yields, and phthalimidomethyl esters are formed in low yields. It was shown that the reaction of esterification of halogen acids with N-hydroxymethylphthalimide proceeds with monomolecular nucleophilic exchange.

Maqola ma’lumotlari
JurnalKimyo va kimyo texnologiyasi
NashriyotТошкент кимё-технология институти
ISSN1992-9498, 2181-1121
Nashr sanasi2020-12-04
Jild2020
Son3
Betlar38-43
TilIngliz
Ilmiy sohaKimyo
DOI10.51348/ddfx3944
Indeksga qo‘shilgan2026-09-02

DOI: 10.51348/ddfx3944 · Maqolaning asl sahifasi

Ilmiy soha

Kimyo

Iqtibos keltirish

APANoma’lum muallif (2020). SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS. Kimyo va kimyo texnologiyasi, 2020(3), 38-43. https://doi.org/10.51348/ddfx3944
GOST (OAK)Noma’lum muallif SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS // Kimyo va kimyo texnologiyasi. – 2020. – T. 2020, № 3. – P. 38-43. – DOI: 10.51348/ddfx3944.
MLANoma’lum muallif. “SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS.” Kimyo va kimyo texnologiyasi, 2020(3), 38-43, 2020. https://doi.org/10.51348/ddfx3944
ChicagoNoma’lum muallif. “SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS.” Kimyo va kimyo texnologiyasi, 2020(3), 38-43 (2020). https://doi.org/10.51348/ddfx3944
HarvardNoma’lum muallif (2020) ‘SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS’, Kimyo va kimyo texnologiyasi, 2020(3), 38-43. https://doi.org/10.51348/ddfx3944
BibTeX
@article{article2020,
  title = {SYNTHESIS OF ESTERS OF HALOGENOACETIC ACIDS},
  author = {Unknown},
  journal = {Kimyo va kimyo texnologiyasi},
  year = {2020},
  volume = {2020},
  number = {3},
  pages = {38-43},
  doi = {10.51348/ddfx3944},
  url = {https://doi.org/10.51348/ddfx3944}
}

Boshqa maqola uchun iqtibos tayyorlash

Kimyo va kimyo texnologiyasi jurnalidan boshqa maqolalar

Kimyo va kimyo texnologiyasi — barcha maqolalar · 2020-yil arxivi

Kimyo sohasidagi boshqa maqolalar

Kimyo sohasidagi OAK jurnallari